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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
KUWANON-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICORICIDIN 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICURASIDE IC50=0.56 uM *
LINARIIN IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LINARIN IC20=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LONICERIN IC56=1uM; IC92=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN EC=3 ppm Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.
LUTEOLIN IC50=0.45 uM rat *
LUTEOLIN-7-GLUCOSIDE IC73=10 uM *
LUTEOLIN-7-GLUCOSIDE IC31=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC88=10 uM *
LUTEOLIN-7-GLUCURONIDE IC68=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDURONIC-ACID IC50=3.1 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
MACROCARPAL-A IC50=2 uM *
MACROCARPAL-A IC50=10 uM *
MACROCARPAL-B IC50=2.8 uM *
MACROCARPAL-D IC50=2 uM *
MACROCARPAL-G IC50=2.7 uM *
MANDSHURIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
MANIFLAVONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Pouteria caimito Abiu; Caimito 1 3, 780
Pouteria campechiana Canistel 1 1, 475
Pouteria viridis Green Sapote; Sapote Verde 1 2, 720
Prosopis juliflora Mesquite 1 0
Prunella vulgaris Self-Heal; Heal-All 12 492, 000
Prunus aequinoctialis 1 0
Prunus africana Bitter Almond; Red Stinkwood 1 220
Prunus armeniaca Apricot 13 36, 145
Prunus avium Cereza; Sweet Cherry 1 0
Prunus cerasus Sour Cherry 16 873
Prunus domestica Plum 6 699
Prunus dulcis Almond 8 63
Prunus laurocerasus Cherry Laurel 6 15, 000
Prunus mahaleb 1 0
Prunus maximowiczii 1 0
Prunus nipponica 1 0
Prunus persica Peach 11 1, 127
Prunus salicifolia Capulin; Wild Cherry 1 2, 830
Prunus serotina Black Cherry; Wild Cherry 6 31, 124
Prunus spinosa Blackthorn; Sloe 6 0