An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. Aldose-Reductase-Inhibitor

Aldose-Reductase-Inhibitor

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
TRIFOLIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
TRIFOLIN IC19=1 uM *
UMBELLIFERONE IC50=4.8 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID 100 uM/l *
VERBASCOSIDE IC50=0.39-15.1 uM *
VITEXICARPIN 100 uM/l *
VITEXIN 5 ug/ml Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
VITEXIN IC15=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WARANGALONE 10 uM Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN IC13=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN IC50=48 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE IC50=40 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER IC50=39 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Feijoa sellowiana Brazillian Guava; Guava Brazilera 1 3, 500
Ferula alliacea Garlic Ferula 1 0
Ferula assa-foetida Asafetida; Asafoetida; Assa-foetida; Devil's Dung; Stinkasant (Ger.); Asafetida (Sp.); test 4 889, 700
Ferula gummosa Galbanum 2 0
Ferula sumbul Sumbul 2 0
Ficus carica Fig; Figuier Commun (Fr.); Echte Feige (Ger.); Feigenbaum (Ger.); Fico (Ital.); Figueira (Port.); Higo (Sp.); Higuera Comun (Sp.) 15 271, 352
Filipendula ulmaria Meadowsweet; Queen Of The Meadow 9 32
Flemingia strobilifera 1 18
Foeniculum vulgare Fennel 21 173, 527.5
Forsythia suspensa Lian-Jiao; Lien-Chiao 3 4, 000
Fragaria spp Strawberry 11 136, 242
Frangula alnus Buckthorn 2 0
Frangula purshiana Cascara Sagrada; Cascara Buckthorn 3 0
Fraxinus ornus Ash 1 0
Fraxinus rhynchophylla Chinese Ash 1 0
Fucus vesiculosus Bladderwrack; Kelp 1 516
Galactia jussiaeana 1 0
Galega officinalis Goat's Rue; Galega 5 520
Galeopsis tetrahit Hemp Nettle 1 40
Galium odoratum Waldmeister; Woodruff 2 26, 000