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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
PROTOPINE IC50=38.5 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
PRUNASIN 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PUERARIN *
QUERCETAGETIN IC29=1 uM *
QUERCETAGETIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCETIN 100 uM *
QUERCETIN 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
QUERCETIN IC50=0.84 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
QUERCETIN IC50=0.344 uM Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.
QUERCIMERITRIN IC20=1 uM *
QUERCIMERITRIN IC44=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCITRIN IC55=0.15 uM *
QUERCITRIN 0.1-100 uM *
QUERCITRIN 0.5-4 ug/ml *
QUERCITRIN IC50=64 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
QUERCITRIN IC55=0.1 uM *
QUERCITRIN IC50=2 uM Terashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
QUERCITRYL-2'-ACETATE IC87=0.1uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
RESORCINOL 909.1 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
REYNOUTRIN IC34=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Feijoa sellowiana Brazillian Guava; Guava Brazilera 1 3, 500
Ferula alliacea Garlic Ferula 1 0
Ferula assa-foetida Asafetida; Asafoetida; Assa-foetida; Devil's Dung; Stinkasant (Ger.); Asafetida (Sp.); test 4 889, 700
Ferula gummosa Galbanum 2 0
Ferula sumbul Sumbul 2 0
Ficus carica Fig; Figuier Commun (Fr.); Echte Feige (Ger.); Feigenbaum (Ger.); Fico (Ital.); Figueira (Port.); Higo (Sp.); Higuera Comun (Sp.) 15 271, 352
Filipendula ulmaria Meadowsweet; Queen Of The Meadow 9 32
Flemingia strobilifera 1 18
Foeniculum vulgare Fennel 21 173, 527.5
Forsythia suspensa Lian-Jiao; Lien-Chiao 3 4, 000
Fragaria spp Strawberry 11 136, 242
Frangula alnus Buckthorn 2 0
Frangula purshiana Cascara Sagrada; Cascara Buckthorn 3 0
Fraxinus ornus Ash 1 0
Fraxinus rhynchophylla Chinese Ash 1 0
Fucus vesiculosus Bladderwrack; Kelp 1 516
Galactia jussiaeana 1 0
Galega officinalis Goat's Rue; Galega 5 520
Galeopsis tetrahit Hemp Nettle 1 40
Galium odoratum Waldmeister; Woodruff 2 26, 000