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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
TRIFOLIN IC19=1 uM *
TRIFOLIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
UMBELLIFERONE IC50=4.8 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID 100 uM/l *
VERBASCOSIDE IC50=0.39-15.1 uM *
VITEXICARPIN 100 uM/l *
VITEXIN IC15=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
VITEXIN 5 ug/ml Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
WARANGALONE 10 uM Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN IC13=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN IC50=48 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE IC50=40 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER IC50=39 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Hydrangea paniculata Peegee 2 82, 000
Hydrastis canadensis Goldenseal 2 681
Hylocereus guatemalensis Guatemala Cereus; Nopalito De Guatemala 1 1, 030
Hylocereus undatus Night-Blooming Cereus; Nopalito De Noche; Strawberry Pear; Belle-of-the-Night; Queen-of-the-Night 1 2, 575
Hyoscyamus niger Henbane 3 0
Hypericum perforatum Common St. Johnswort; Hypericum; Klamath Weed; St. John's-wort; Goatweed 23 1, 396, 837.5
Hyptis spicata Spicate Hyptis 1 0
Hyptis suaveolens Wild Hops 4 456
Hyssopus officinalis Hyssop 8 8, 593.10000000149
Ilex paraguariensis Mate; Paraguay Tea; South American Holly 2 0
Illicium verum Star Anise; Chinese Star Anise; Chinesischer Sternanis (Ger.); Sternanis (Ger.); anis de China (Sp.); anis estrellado (Sp.) 8 25, 176
Inga edulis Guaba; Icecream Bean 1 710
Inonotus obliquus 2 0
Inula helenium Elecampane 4 20
Ipomoea aquatica Swamp Cabbage; Water Spinach 1 14, 600
Ipomoea batatas Sweet Potato 5 5, 420
Ipomoea purga Jalap 2 40, 000
Iris versicolor Blue Flag 1 0
Iris x germanica Orris 1 9, 930
Isanthus brachiatus False Pennyroyal 3 90