An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. Aldose-Reductase-Inhibitor

Aldose-Reductase-Inhibitor

Select a Results View:

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
PROTOPINE IC50=38.5 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
PRUNASIN 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PUERARIN *
QUERCETAGETIN IC29=1 uM *
QUERCETAGETIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCETIN IC50=0.344 uM Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.
QUERCETIN 100 uM *
QUERCETIN 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
QUERCETIN IC50=0.84 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
QUERCIMERITRIN IC20=1 uM *
QUERCIMERITRIN IC44=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCITRIN 0.1-100 uM *
QUERCITRIN 0.5-4 ug/ml *
QUERCITRIN IC50=64 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
QUERCITRIN IC55=0.1 uM *
QUERCITRIN IC50=2 uM Terashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
QUERCITRIN IC55=0.15 uM *
QUERCITRYL-2'-ACETATE IC87=0.1uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
RESORCINOL 909.1 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
REYNOUTRIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Cimicifuga racemosa Black Cohosh; Black Snakeroot 3 270
Cinchona officinalis Lojabark; Quinine 1 0
Cinchona pubescens Quinine; Red Cinchona; Red Peruvian-Bark; Redbark 3 0
Cinchona spp Quinine 1 0
Cinnamomum aromaticum Cassia; Cassia Bark; Cassia Lignea; Chinese Cassia; Chinese Cinnamon; China Junk Cassia; Saigon Cinnamon; Zimtcassie (Ger.); Canela de la China (Sp.); Canelero chino (Sp.); Chinazimt (Ger.); Chinesischer Zimtbaum (Ger.); Kashia-Keihi (Jap.); Canelle de Cochinchine (Fr.); Cannelier Casse (Fr.); Cannelier de Chine (Fr.) 7 4, 944
Cinnamomum camphora Camphor; Ho Leaf 9 2, 220
Cinnamomum verum Cinnamon; Ceylon Cinnamon 10 7, 774.799999237061
Cistus ladaniferus Ambreine; Gum Cistus; Labdanum; Rockrose 4 8, 680
Citrullus colocynthis Colocynth 4 122
Citrullus lanatus Watermelon 4 33, 094
Citrus aurantiifolia Lime 6 8, 564
Citrus aurantium Petitgrain; Bitter Orange 16 16, 736
Citrus limon Lemon 18 344, 537.5
Citrus mitis Calamansi; Calamondin 4 23, 198
Citrus paradisi Grapefruit 17 217, 693
Citrus reticulata Mandarin; Tangerine 13 410, 882.6000006199
Citrus sinensis Orange 17 217, 937.66000041366
Citrus spp Citrus 1 0
Clematis vitalba Traveler's Joy 2 0
Cleonia lusitanica Spanish Heal-All 3 16