Chemical ID
PROTOPINE
Ubiquitous
No
Dosage |
---|
LDlo=100 (ipr rat) |
Activity | Dosage | Reference |
---|---|---|
Abortifacient | 70 mg/kg | Duke, 1992 * |
Aldose-Reductase-Inhibitor | 50 uM | Kubo, M., et al. 1994. Studies on Anti-cataract Drugs from Natural Sources. I. Effects of a Methanolic Extract and the Alkaloidal Components from Corydalis Tuber on in vit Aldose Reductase Activity. Biol Pharm Bull, 17(3): 458-459. |
Aldose-Reductase-Inhibitor | IC50=38.5 uM rat | Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47. |
Amphicholeretic | not available | Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. |
Analgesic | not available | Duke, 1992 * |
Antiaggregant | 100-1,000 uM | Duke, 1992 * |
Antiarrhythmic | not available | Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. |
Antibacterial | not available | Duke, 1992 * |
Anticholinergic | not available | Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. |
Antiinflammatory | 100 mg/kg | Duke, 1992 * |
Antiseptic | 1,000 ppm | Duke, 1992 * |
Antispasmodic | not available | Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. |
Antispermigenic | not available | Duke, 1992 * |
Antitussive | not available | Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. |
Calcium-Antagonist | not available | Duke, 1992 * |
Convulsant | not available | Duke, 1992 * |
Gram(+)icide | not available | Duke, 1992 * |
Hypertensive | <1 g/kg | Duke, 1992 * |
Hypotensive | >1 mg/kg | Duke, 1992 * |
Myorelaxant | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
---|---|---|---|---|---|
Argemone mexicana | Plant | not available | 840.0 | not available | Duke, 1992 * |
Bocconia arborea | Plant | not available | not available | not available | Duke, 1992 * |
Bocconia frutescens | Plant | not available | not available | not available | Duke, 1992 * |
Chelidonium majus | Plant | not available | not available | not available | Duke, 1992 * |
Corydalis spp | Plant | not available | not available | not available | Duke, 1992 * |
Eschscholzia californica | Shoot | 30.0 | 150.0 | not available | Duke, 1992 * |
Eschscholzia californica | Seed | not available | not available | not available | Duke, 1992 * |
Eschscholzia californica | Root | not available | not available | not available | Duke, 1992 * |
Eschscholzia californica | Plant | not available | not available | not available | Duke, 1992 * |
Glaucium flavum | Root | not available | not available | not available | Duke, 1992 * |
Macleaya cordata | Plant | not available | not available | not available | Duke, 1992 * |
Nandina domestica | Plant | not available | not available | not available | Duke, 1992 * |
Papaver bracteatum | Plant | not available | not available | not available | Duke, 1992 * |
Papaver somniferum | Fruit | not available | not available | not available | Duke, 1992 * |
Papaver somniferum | Tissue Culture | not available | not available | not available | Duke, 1992 * |
Sanguinaria canadensis | Root | not available | not available | not available | Duke, 1992 * |