Chemical PROTOPINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

PROTOPINE

Ubiquitous

List of known dosages
Dosage
LDlo=100 (ipr rat)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Abortifacient	70 mg/kg	Duke, 1992 *
Aldose-Reductase-Inhibitor	50 uM	Kubo, M., et al. 1994. Studies on Anti-cataract Drugs from Natural Sources. I. Effects of a Methanolic Extract and the Alkaloidal Components from Corydalis Tuber on in vit Aldose Reductase Activity. Biol Pharm Bull, 17(3): 458-459.
Aldose-Reductase-Inhibitor	IC50=38.5 uM rat	Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
Amphicholeretic	not available	Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
Analgesic	not available	Duke, 1992 *
Antiaggregant	100-1,000 uM	Duke, 1992 *
Antiarrhythmic	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
Antibacterial	not available	Duke, 1992 *
Anticholinergic	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
Antiinflammatory	100 mg/kg	Duke, 1992 *
Antiseptic	1,000 ppm	Duke, 1992 *
Antispasmodic	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
Antispermigenic	not available	Duke, 1992 *
Antitussive	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Calcium-Antagonist	not available	Duke, 1992 *
Convulsant	not available	Duke, 1992 *
Gram(+)icide	not available	Duke, 1992 *
Hypertensive	<1 g/kg	Duke, 1992 *
Hypotensive	>1 mg/kg	Duke, 1992 *
Myorelaxant	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Argemone mexicana	Plant	not available	840.0	not available	Duke, 1992 *
Bocconia arborea	Plant	not available	not available	not available	Duke, 1992 *
Bocconia frutescens	Plant	not available	not available	not available	Duke, 1992 *
Chelidonium majus	Plant	not available	not available	not available	Duke, 1992 *
Corydalis spp	Plant	not available	not available	not available	Duke, 1992 *
Eschscholzia californica	Seed	not available	not available	not available	Duke, 1992 *
Eschscholzia californica	Root	not available	not available	not available	Duke, 1992 *
Eschscholzia californica	Plant	not available	not available	not available	Duke, 1992 *
Eschscholzia californica	Shoot	30.0	150.0	not available	Duke, 1992 *
Glaucium flavum	Root	not available	not available	not available	Duke, 1992 *
Macleaya cordata	Plant	not available	not available	not available	Duke, 1992 *
Nandina domestica	Plant	not available	not available	not available	Duke, 1992 *
Papaver bracteatum	Plant	not available	not available	not available	Duke, 1992 *
Papaver somniferum	Fruit	not available	not available	not available	Duke, 1992 *
Papaver somniferum	Tissue Culture	not available	not available	not available	Duke, 1992 *
Sanguinaria canadensis	Root	not available	not available	not available	Duke, 1992 *