Podophyllum peltatum | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Mayapple

How used

Medicinal

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Activities: 298

Chemicals w/Activities: 15

All Chemicals: 28

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
2	4'-DEMETHYLPODOPHYLLOTOXIN	Rhizome	--	--	--	*
Topoisomerase-II-Inhibitor 10 ug/ml Figgitt, D. P., Denyer, S. P., Dewick, P. M., Jaackson, D. E., Williams, P. Differential Sensitivity of Fungal Topoisomerases to Podophyllotoxin Derivatives. J Pharm Pharmacol Suppl, 41: 44pp. Topoisomerase-II-Inhibitor 100 uM Lee, K. H., et al. 1989. Antitumor Agents. 107. New Cytotoxic 4-alkylamino Analogues of 4'-demethyl-epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II. J Natural Products, 52: 606-613.
0	4'DEMETHYLDESOXYPODOPHYLLUM-BETA-D-GLUCOSIDE	Rhizome	--	--	--	*
0	4'DEMETHYLPODOPHYLLOTOXINGLUCOSIDE	Rhizome	--	--	--	*
8	ALPHA-PELTATIN	Rhizome	3500.0	6000.0	--	*
Antiherpetic IC69=414 ppb Bedows, E. and Hatfield, G.M. An Investigation of the Antiviral Activity of Podophyllum peltatum. J. Nat. Prod. 45: 725. Antimeasles Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antitumor ED=2 ppm ivn * Antiviral IC70=1uM Bedows, E. and Hatfield, G. M. An investigation of the antiviral activity of Podophyllum peltatum, J. Nat. Prod., 45(6), 1982, 725-9. Hepatoprotective Fitoterapia No.5-1986. Pesticide * Purgative * Topoisomerase-II-Inhibitor Thurston, L. S., Lee, K. H., Han, F. S., Liu, Z. C., Cheng, Y. C. Inhibition of Human DNA Topoisomerase II by Podophyllatoxin Analogues. Abstract Internat Res Cong Nat Prod Coll Pharm University N Carolina, Chapel Hill NC, July 1985.
0	ALPHAPELTATIN-GLUCOSIDE	Plant	--	--	--	*
7	ASTRAGALIN	Plant	--	--	--	*
ACE-Inhibitor ID50=180 ug/ml rat (24 hr.) * Aldose-Reductase-Inhibitor IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC30=1 uM * Antileukemic * Expectorant * Hypotensive Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Immunostimulant *
130	BERBERINE	Plant	--	--	--	*
(+)-Inotropic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Abortifacient * Adrenolytic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Amebicide 200 ug/ml Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Amebicide EC83=100 ug/ml orl rat Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Analgesic * Anesthetic * Antiacetylcholinesterase * Antiacne Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antiadrenergic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiaggregant * Antialzheimeran * Antiamnesic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antiangiogenic * Antiarrhythmic * Antiarthritic * Antibacillus MIC=200 ug/ml * Antibacterial 100 mg/4x/day * Antibacterial 12.5-2,500 ug/ml Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antibacterial MIC=6-630 ug/ml * Antibiotic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticancer * Anticariogenic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antichlamydial * Anticholecystitic 5-20 mg/3x/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticholera 150 mg/man/day Martindale's 28th Anticirrhotic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticonjunctivitic 0.20% Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticonvulsant Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antidiarrheic 100 mg/4x/day * Antidysenteric 100 mg/4x/day * Antiedemic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antiendotoxic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antienterotoxic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiesherichic * Antigiardial 10 mg/kg/day * Antiglaucomic * Antigonorrhea * Antihepatomic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antihepatotic * Antiherpetic * Antihistaminic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiinflammatory * Antiischemic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antileishmanic 10 ug/ml * Antilipogenic IC63=10 uM Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antimalarial 0.14-0.36 ug/ml * Antimalarial 50 uM * Antimitotic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antimuscarinic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antimyalgic * Antimycotic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antineoplastic * Antinephritic * Antiperistaltic Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Antipharyngitic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiphotooxidative * Antiplasmodial IC50=0.14-0.36 ug/ml * Antipneumonic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antipyretic 3 x aspirin * Antisalmonella * Antisecretory * Antiseptic 25 ug/ml * Antishigellic 12.5 ug/ml Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antispasmodic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antispermigenic * Antistaphylococcic * Antistrep Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antisyphilitic * Antitrachomic 0.20% * Antitrypanosomic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antitubercular MIC=25 ug/ml * Antitumor (brain) IC91=150 ug/ml Werbach & Murray, 1994. Antiulcer * Antivaginitic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiviral Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Astringent * Bilirubinolytic * Calcium-Antagonist Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Candidicide * Cardiodepressant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Cardiotonic * Carminative Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Cholagogue * Cholekinetic * Choleretic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Collyrium * COX-2-Inhibitor 100 ug/ml * Cyclooxygenase-Inhibitor * Cytotoxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Digestive * Diuretic * Emetic * Fungicide 12.5-150 ug/ml Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Glaucomagenic * Hemostat * Hypocholesterolemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypoglycemic * Hypotensive * Immunostimulant * Lachrymatory Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Larvicide 9 ppm * Leucocytogenic * Lipase-Inhibitor Medline (post 1990 searches filed in my computer) Lipoxygenase-Inhibitor IC50=118 uM * Mutagenic * Mycobactericide MIC=25-50 ug/ml * Mydriatic Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Myocardiodepressant * Myorelaxant * Pesticide * Phototoxic 9 ppm * Plasmodicide IC50=0.14-0.36 ug/ml * Prostaglandin-Synthesis-Inhibitor 25 mg/kg ivn rbt Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528. Protisticide IC50=0.14-0.36 ug/ml * Respiradepressant Martindale's 28th RNA-Depressant * RT-Inhibitor * Sedative * Stomachic * Topoisomerase-II-Inhibitor 2.5 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418. Trichomonicide Martindale's 29th Trypanocide * Uterocontractant * Uterotonic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Vagostimulant man * Vasoconstrictor * Vasodilator 2 mg/kg cat * Vermifuge * Vibriofuge *
8	BETA-PELTATIN	Rhizome	1750.0	3000.0	--	*
Antiherpetic IC78=414 ppb Bedows, E. and Hatfield, G.M. An Investigation of the Antiviral Activity of Podophyllum peltatum. J. Nat. Prod. 45: 725. Antimeasles Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antitumor ED=2 ppm iv * Antiviral IC78=1uM=400 ppb Bedows, E. and Hatfield, G. M. An investigation of the antiviral activity of Podophyllum peltatum, J. Nat. Prod., 45(6), 1982, 725-9. Hepatoprotective * Irritant Merck 11th Edition Pesticide * Purgative *
0	BETA-PELTATIN-GLUCOSIDE	Rhizome	--	--	--	*
4	CALCIUM-OXALATE	Plant	--	--	--	*
Emetic * Inflammatory * Laxative * Lithogenic *
0	DEHYDROPODOPHYLLOTOXIN	Root	--	--	--	*
8	DESOXYPODOPHYLLOTOXIN	Root	--	1000.0	--	*
Anticarcinomic 2.6 ppb * Antiherpetic Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp. Antitumor (Nasopharynx) Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp. Antiviral IC84=1 uM Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 207. Insecticide * Larvicide * Pesticide *
62	GALLIC-ACID	Plant	--	--	--	*
ACE-Inhibitor IC50=7.7 mM/l * Analgesic * Antiadenovirus Economic & Medicinal Plant Research, 5: 194. Antiallergenic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Antianaphylactic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiangiogenic * Antiasthmatic Watt, J.M., and Breyer-Brandwijk, M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 1962. Antibacterial MIC=1,000 ug/ml * Antibronchitic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Anticancer * Anticarcinomic ED50=3 * Antiescherichic * Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antiflu Economic & Medicinal Plant Research, 5: 194. Antihepatotoxic Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Antiherpetic EC50=>10 ug/ml * AntiHIV * Antiinflammatory Kroes, B.H., et al. 1991. Anti-Inflammatory Activity of Gallic Acid. Planta Medica, 58(6): 499. Antileishmanic EC50=4.4 ug/ml * AntiMRSA * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antinitrosaminic * Antioxidant 7 x quercetin * Antioxidant IC44=33 ppm * Antioxidant 2/3 BHA * Antiperiodontitic 10 ug/ml * Antiperoxidant IC50=69 uM * Antipolio Economic & Medicinal Plant Research, 5: 194. Antiproteolytic 10 ug/ml * Antiradicular IC50=4.9 uM * Antiradicular 7 x quercetin * Antiseptic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic MIC=1,000 ug/ml * Antitumor * Antitumor-Promoter * Antiviral * Apoptotic * Astringent Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Bacteristat Lamikanra, A., Ogundaini, A.O., and Ogungbamila, F.O. Antibacterial Constituents of Alchornea cordifolia Leaves. Phytotherapy Research 4(5): 198. Bronchodilator Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Carcinogenic * Choleretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cyclooxygenase-Inhibitor * Cytotoxic 500 uM * Floral-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Gram(+)icide MIC=1,000 ug/ml * Gram(-)icide MIC=1,000 ug/ml * Hemostat * Hepatoprotective Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Immunomodulator * Immunostimulant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Immunosuppressant * Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Nephrotoxic Martindale's 29th NO-Inhibitor IC-26=250 uM * Pesticide * Styptic * Topoisomerase-I-Inhibitor Hamada, S. I., Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. 1997. Immunosuppressive Effects by Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity. Biol Pharm Bull, 20: 1017-1019. Xanthine-Oxidase-Inhibitor IC50=24 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
11	ISORHAMNETIN	Plant	--	--	--	*
Antibacterial * Antihistaminic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antiinflammatory Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antioxidant Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210. MAO-Inhibitor * Pesticide * Quinone-Reductase-Inducer Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630. Vasodilator *
75	KAEMPFEROL	Rhizome	--	--	--	*
11B-HSD-Inhibitor * 5-Lipoxygenase-Inhibitor IC50 (uM)=20 * Aldose-Reductase-Inhibitor 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213. Antiaflatoxin IC50=8.73 uM * Antiaflatoxin IC50=3.28 ppm * Antiaggregant 30 uM * Antiallergic * Antibacterial 20 ug/ml * Anticancer * Antifertility 250 mg/kg/day/60 days/orl rat Kumar, P., Dixit, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989. Antigingivitic 20 ug/ml Antiherpetic 23-92 ug/ml Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992. Antihistaminic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antiimplantation * Antiinflammatory 20 mg/kg * Antiinflammatory 200 mg/kg ipr rat * Antileukemic IC50=3.1 ug/ml Life Sciences 55: 1061. Antilymphocytic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant IC50=40 uM * Antioxidant 3/4 quercetin * Antioxidant IC50=1.2 ug/ml * Antiperiodontic 20 ug/ml * Antiplaque 20 ug/ml * Antiradicular 7 x quercetin * Antiseptic 20 ug/ml * Antiserotonin 200 mg/kg ipr rat * Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic * Antitumor * Antitumor-Promoter Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990. Antiulcer 50-200 mg/kg ipr rat * Antiviral 23-92 ug/ml * Apoptotic 60 uM * Aromatase-Inhibitor IC12=1 uM/l Journal of Medicinal Food 2: 235.1999. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp. Choleretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Copper-Chelator * COX-2-Inhibitor * Cyclooxygenase-Inhibitor IC50 (uM) =20 * Cytotoxic * Diaphoretic? Lawrence Review of Natural Products, Dec-90. Diuretic * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Estrogenic EC50=0.56 uM * Fungicide 20 ug/ml Father Nature's Farmacy: The aggregate of all these three-letter citations. Hepatoprotective IC50=5.46 uM * Hepatoprotective IC50=1.30 ppm * HIV-RT-Inhibitor IC50=50-150 ug/ml Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991. Hypotensive * ICAM-1-Inhibitor * iNOS-Inhibitor IC50=<15 uM * iNOS-Inhibitor IC50=13.9 uM * Inotropic * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. JNK-Inhibitor * Lipoxygenase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. MAO-Inhibitor * Mutagenic * Natriuretic * Neuroprotective * NO-Inhibitor IC50=13.9 uM * PAF-Inhibitor * Pesticide * Protisticide Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105. Quinone-Reductase-Inducer 3 uM * Teratologic * TNF-alpha-Inhibitor IC50=3.99 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC50=8.1 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225. Tyrosinase-Inhibitor ID50=230 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator *
0	KAEMPFEROL-3-0-GLUCOSIDE	Rhizome	--	--	--	*
0	LIGNAN-K	Plant	--	--	--	*
0	LIGNAN-M	Plant	--	--	--	*
0	METHYLPODOPHYLLOQUERCETIN	Root	--	--	--	*
1	PICROPODOPHYLLIN	Rhizome	--	--	--	*
Antihepatotoxic *

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Podophyllum peltatum (Berberidaceae)

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