Perilla frutescens | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Perilla

How used

Food

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Activities: 613

Chemicals w/Activities: 107

All Chemicals: 172

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List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	(2E,4E,63)-ALLOFARNESENE	Plant	--	--	--	J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
0	(2Z,4E,63)-ALLOFARNESENE	Plant	--	--	--	J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
0	12-ACETYLOCTADEC-9-ENOIC-ACID	Leaf	--	--	--	Lee, K. I., Rhee, S. H., Park, K. Y., Kim, J. O. 1992. Antimutagenic Compounds Identified from Perilla Leaf. Han'guk Yongyang Siklyong Hakhoe Chi, 21(3): 302-307.
1	3',4',5,7-TETRAHYDROXYFLAVONE	Plant	--	--	--	*
Antioxidant *
0	3(S)-HYDROXY-4(R)-(1-METHYL-ETHENYL)-CYCLOHEX-1-ENE-1-CARBOXALDEHYDE	Shoot	--	122.0	--	Tada, M., Matsumoto, R., Chiba, K. 1996. An Oxidative Metabolite of Perillaldehyde from Perilla frutescens. Phytochemistry, 43(4): 803-804.
0	3,4-DIHYDROXYBENZALDEHYDE	Plant	--	--	--	*
1	3,4-DIHYDROXYBENZOATE	Plant	--	--	--	*
Antioxidant *
1	6,7-DIHYDROXYCOUMARIN	Plant	--	--	--	*
Antioxidant *
0	ALPHA-BERGAMOTENE	Leaf Essent. Oil	--	35000.0	--	Kang, R., Helms, R., Stout, M.J., Jaber, H., Chen, Z., and Nakatsu, T. 1992. Antimicrobial Activity of the Volatile Constituents of Perilla frutescens and Its Synergistic Effects with Polygodial. J. Agric. Food Chem., 40: 2328-2330.
0	ALPHA-BERGAMOTENE	Plant	--	--	--	Kang, R., Helms, R., Stout, M.J., Jaber, H., Chen, Z., and Nakatsu, T. 1992. Antimicrobial Activity of the Volatile Constituents of Perilla frutescens and Its Synergistic Effects with Polygodial. J. Agric. Food Chem., 40: 2328-2330.
0	ALPHA-CARYOPHYLLENE	Leaf Essent. Oil	--	1300.0	--	Kang, R., Helms, R., Stout, M.J., Jaber, H., Chen, Z., and Nakatsu, T. 1992. Antimicrobial Activity of the Volatile Constituents of Perilla frutescens and Its Synergistic Effects with Polygodial. J. Agric. Food Chem., 40: 2328-2330.
0	ALPHA-COPAENE	Shoot Essent. Oil	--	12000.0	1.00	Nguyen, X. D., La, D. M., Lu'u, D. C., Leclercq, P. A. 1995. Essential Oil Constituents from the Aerial Parts of Perilla frutescens (L.) Britton. J. Essent. Oil Res., 7(4): 429-432.
2	ALPHA-HUMULENE	Shoot Essent. Oil	--	13000.0	1.10	Nguyen, X. D., La, D. M., Lu'u, D. C., Leclercq, P. A. 1995. Essential Oil Constituents from the Aerial Parts of Perilla frutescens (L.) Britton. J. Essent. Oil Res., 7(4): 429-432.
Antitumor Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992. Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
11	ALPHA-PHELLANDRENE	Shoot Essent. Oil	--	--	--	Nguyen, X. D., La, D. M., Lu'u, D. C., Leclercq, P. A. 1995. Essential Oil Constituents from the Aerial Parts of Perilla frutescens (L.) Britton. J. Essent. Oil Res., 7(4): 429-432.
Antibacterial Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antistaphylococcic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Dermal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Emetic * FLavor FEMA 10-130 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Insectiphile Pakistan Encyclopedia Planta Medica. 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide *
28	ALPHA-PINENE	Shoot Essent. Oil	--	7000.0	-0.48	Nguyen, X. D., La, D. M., Lu'u, D. C., Leclercq, P. A. 1995. Essential Oil Constituents from the Aerial Parts of Perilla frutescens (L.) Britton. J. Essent. Oil Res., 7(4): 429-432.
Allelochemic * Allergenic * Antiacne * Antibacterial * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory 500 mg/kg * Antipneumonic * Antiseptic * Antispasmodic * Antistaphylococcic * Antiviral Economic & Medicinal Plant Research, 5: 195. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Coleoptophile * Expectorant Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. FLavor FEMA 15-150 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide IC50=30 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insecticide 0.82 uM/fly * Insectifuge 50 ppm * Insectiphile J. Stored. Prod. Res., 22:141, 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. P450-2B1-Inhibitor IC50=0.087 uM * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Sedative Lawrence Review of Natural Products, Jun-90. Spasmogenic * Tranquilizer Lawrence Review of Natural Products, Jun-90. Transdermal *
28	ALPHA-PINENE	Plant	--	--	--	J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
Allelochemic * Allergenic * Antiacne * Antibacterial * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory 500 mg/kg * Antipneumonic * Antiseptic * Antispasmodic * Antistaphylococcic * Antiviral Economic & Medicinal Plant Research, 5: 195. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Coleoptophile * Expectorant Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. FLavor FEMA 15-150 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide IC50=30 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insecticide 0.82 uM/fly * Insectifuge 50 ppm * Insectiphile J. Stored. Prod. Res., 22:141, 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. P450-2B1-Inhibitor IC50=0.087 uM * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Sedative Lawrence Review of Natural Products, Jun-90. Spasmogenic * Tranquilizer Lawrence Review of Natural Products, Jun-90. Transdermal *
0	ALPHA-TERPINEOL ACETATE	Leaf Essent. Oil	--	1300.0	-1.27	Kang, R., Helms, R., Stout, M.J., Jaber, H., Chen, Z., and Nakatsu, T. 1992. Antimicrobial Activity of the Volatile Constituents of Perilla frutescens and Its Synergistic Effects with Polygodial. J. Agric. Food Chem., 40: 2328-2330.
8	AMYGDALIN	Leaf	--	--	--	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiinflammatory * Antispasmodic * Antitussive Oriental Materia Medica (three volumes by Dr. Hsu and collaborators) Bitter * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cyanogenic Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp. Expectorant Oriental Materia Medica (three volumes by Dr. Hsu and collaborators) Toxic *
30	ANTHOCYANINS	Leaf	--	--	--	Koezuka, Y., Honda, G., Sakamoto, S., Tabata, M. 1985. Genetic Control of Anthocyanin Production in Perilla frutescens. Shoyakugaku Zasshi, 39(3): 228-231.
Antiapoptotic * Antiarthritic 120 mg/man orl * Anticancer 120 mg/man orl * Anticarcinogenic * Anticollegenase * Antidiabetic * Antielastase * Antihyperglycemic * Antihyperinsulinemic * Antihyperleptinemic * Antiinflammatory * Antimutagenic * Antimyopic 600 mg/man orl * Antinyctalopic 600 mg/man orl * Antiobesity * Antioxidant * Antiproliferant * Antitumor 120 mg/man orl * Antivaricose * Antiviral * Chemopreventive * COX-1-Inhibitor IC45=125 ug/ml * COX-2-Inhibitor IC47=125 ug/ml * Goitrogenic * Hemostat * NO-Scavenger * Pesticide * Vasoactive * Vasodilator * Vasoprotective *
101	APIGENIN	Seed	--	--	--	CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=9.52 uM * Antiaflatoxin IC50=2.57 ppm * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC72=200 ug/ml * AntiHIV IC50=143 ug/ml * Antiinflammatory #NAME? * Antiinflammatory IC~65=1,000 uM * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antimutagenic ID50=0.55 ug/ml * Antioxidant 1.5 x Vit. E * Antioxidant IC28.5=62.5 ug/ml * Antiperistaltic * Antiproliferant 1-50 uM * Antiproliferant IC50=155 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor <40 uM * COX-2-Inhibitor IC>65=1,000 uM * COX-2-Inhibitor IC50=<15 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic IC50=9.5 uM * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Cytotoxic 1-50 uM * Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Estrogenic 16% genistein * Estrogenic EC50=1 uM * HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Topoisomerase-II-Inhibitor IC45=180 uM * Topoisomerase-II-Inhibitor IC28=18 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *

List of all activity chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Perilla frutescens (Lamiaceae)

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