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Chemical ID
CAFFEINE
CAS Registry Number
58082
Ubiquitous
No
| Dosage | Reference |
|---|---|
| LD50=127-1,200 (orl mus) | Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition |
| LD50=192 (orl rat) | |
| LD50=200 (orl rat) | |
| LD50=224-246 (orl rbt) | |
| LD50=247-355 (orl rat) | Merck 11th Edition |
| LDlo=192 (orl hmn) |
| Activity | Dosage | Reference |
|---|---|---|
| FLavor | FEMA 125 | Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry |
| Herbicide | not available | Duke, 1992 * |
| Hypertensive | not available | Duke, 1992 * |
| Hypoglycemic | not available | Duke, 1992 * |
| Insecticide | not available | Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. |
| Lypolytic | not available | Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. |
| Myorelaxant | not available | McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. |
| Neurotoxic | not available | R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. |
| Pesticide | not available | Duke, 1992 * |
| Phosphodiesterase-Inhibitor | not available | Duke, 1992 * |
| Pyrogenic | 60 mg/day oral hmn | Daroca, P., Rodriguez, J., Reano, M., Canto, G., Miranda, P. 1996. Fever From Caffeine. Allergy, 51(3): 189-191. |
| Pyrogenic | 13.3 mg/kg ipr rbt | Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392. |
| Pyrogenic | 15 mg/kg ipr cat | Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392. |
| Respirastimulant | not available | Duke, 1992 * |
| Spasmogenic | 1,500 mg/man | Duke, 1992 * |
| Stimulant | not available | R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. |
| Tachycardic | 1,500 mg/man | Duke, 1992 * |
| Teratogenic | 14 orl rat | Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. |
| Topoisomerase-I-Inhibitor | 0.1 nM | Tohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132. |
| Topoisomerase-I-Inhibitor | 75 uM | Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52. |
| Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
|---|---|---|---|---|---|
| Guazuma ulmifolia | Leaf | not available | not available | not available | Duke, 1992 * |
| Ilex paraguariensis | Leaf | 2000.0 | 20000.0 | -0.4 | Duke, 1992 * |
| Paullinia cupana | Plant | not available | 25000.0 | not available | Duke, 1992 * |
| Paullinia cupana | Seed | 9100.0 | 76000.0 | 2.2 | Duke, 1992 * |
| Paullinia yoko | Leaf | not available | not available | not available | Duke, 1992 * |
| Paullinia yoko | Bark | not available | 27300.0 | not available | Duke, 1992 * |
| Theobroma angustifolium | Petiole | 80.0 | 82.0 | -1.1 | Duke, 1992 * |
| Theobroma angustifolium | Seed | 35.0 | 57.0 | -1.0 | Duke, 1992 * |
| Theobroma angustifolium | Testa | 38.0 | 52.0 | -1.0 | Duke, 1992 * |
| Theobroma bicolor | Fruit | 158.0 | 184.0 | not available | Duke, 1992 * |
| Theobroma bicolor | Petiole | 72.0 | 138.0 | -0.3 | Duke, 1992 * |
| Theobroma bicolor | Seed | 110.0 | 147.0 | -1.0 | Duke, 1992 * |
| Theobroma bicolor | Testa | 192.0 | 235.0 | -0.4 | Duke, 1992 * |
| Theobroma cacao | Petiole | 51.0 | 252.0 | 1.3 | Duke, 1992 * |
| Theobroma cacao | Seed | 500.0 | 12900.0 | -0.5 | Duke, 1992 * |
| Theobroma cacao | Testa | 130.0 | 723.0 | 1.4 | Duke, 1992 * |
| Turnera diffusa | Shoot | not available | not available | not available | Duke, 1992 * |
| Turnera diffusa | Leaf | not available | not available | not available | Duke, 1992 * |