Chemical CAFFEINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

CAFFEINE

CAS Registry Number

58082

Ubiquitous

List of known dosages
Dosage	Reference
LD50=127-1,200 (orl mus)	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition
LD50=192 (orl rat)
LD50=200 (orl rat)
LD50=224-246 (orl rbt)
LD50=247-355 (orl rat)	Merck 11th Edition
LDlo=192 (orl hmn)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Antiserotonergic	40 ipr rat	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Antitumor	not available	Duke, 1992 *
Antitumor (Lung)	not available	Duke, 1992 *
Antivaccinia	not available	Duke, 1992 *
Antiviral	not available	Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Apoptotic	not available	Duke, 1992 *
Arrhythmigenic	1,500 mg/man	Duke, 1992 *
cAMP-Phosphodiesterase-Inhibitor	not available	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Cancer-Preventive	not available	Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Cardiotonic	10-25 orl dog	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Cardiotonic	65-500 orl cat	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Catabolic	not available	Abstract (See species file)
cGMP-Phosphodiesterase-Inhibitor	not available	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Choleretic	not available	Duke, 1992 *
CNS-Stimulant	100 orl mus	Duke, 1992 *
CNS-Stimulant	30 orl rat	Duke, 1992 *
Coronary-Dilator	not available	McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82.
Diuretic	not available	Duke, 1992 *
Energizer	20-200 mg/man	Duke, 1992 *
Ergotamine-Enhancer	not available	Martindale's 29th

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Guazuma ulmifolia	Leaf	not available	not available	not available	Duke, 1992 *
Ilex paraguariensis	Leaf	2000.0	20000.0	-0.4	Duke, 1992 *
Paullinia cupana	Plant	not available	25000.0	not available	Duke, 1992 *
Paullinia cupana	Seed	9100.0	76000.0	2.2	Duke, 1992 *
Paullinia yoko	Bark	not available	27300.0	not available	Duke, 1992 *
Paullinia yoko	Leaf	not available	not available	not available	Duke, 1992 *
Theobroma angustifolium	Petiole	80.0	82.0	-1.1	Duke, 1992 *
Theobroma angustifolium	Seed	35.0	57.0	-1.0	Duke, 1992 *
Theobroma angustifolium	Testa	38.0	52.0	-1.0	Duke, 1992 *
Theobroma bicolor	Petiole	72.0	138.0	-0.3	Duke, 1992 *
Theobroma bicolor	Seed	110.0	147.0	-1.0	Duke, 1992 *
Theobroma bicolor	Testa	192.0	235.0	-0.4	Duke, 1992 *
Theobroma bicolor	Fruit	158.0	184.0	not available	Duke, 1992 *
Theobroma cacao	Petiole	51.0	252.0	1.3	Duke, 1992 *
Theobroma cacao	Seed	500.0	12900.0	-0.5	Duke, 1992 *
Theobroma cacao	Testa	130.0	723.0	1.4	Duke, 1992 *
Turnera diffusa	Shoot	not available	not available	not available	Duke, 1992 *
Turnera diffusa	Leaf	not available	not available	not available	Duke, 1992 *