Chemical BERBERINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Dr. Duke's Phytochemical and Ethnobotanical Databases

U.S. Department of Agriculture

Chemical ID

BERBERINE

Ubiquitous

No

List of known dosages
Dosage	Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Topoisomerase-II-Inhibitor	2.5 uM	Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
Trichomonicide	not available	Martindale's 29th
Trypanocide	not available	Duke, 1992 *
Uterocontractant	not available	Duke, 1992 *
Uterotonic	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Vagostimulant	man	Duke, 1992 *
Vasoconstrictor	not available	Duke, 1992 *
Vasodilator	2 mg/kg cat	Duke, 1992 *
Vermifuge	not available	Duke, 1992 *
Vibriofuge	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Mahonia repens	Stem	not available	not available	not available	Suess, T. R. and Stermitz, F. R. 1981. The Constituents of Castilleja rhexifolia, Mahonia repens and Oncidium cebolleta. Dissertation Abstract Int B, 42: 1025-1026.
Mahonia siamensis	Stem Bark	not available	2000.0	-1.0	Ruangrungsi, N., De-Eknamkul, W., Lange, G. L. 1984. Studies on Thai Medicinal Plant. Part I. Planta Medica, 50(5): 432-433.
Menispermum canadense	Plant	not available	not available	not available	Duke, 1992 *
Nandina domestica	Plant	not available	not available	not available	Duke, 1992 *
Papaver somniferum	Plant	not available	not available	not available	Father Nature's Farmacy: The aggregate of all these three-letter citations.
Phellodendron amurense	Bark	8300.0	10000.0	-1.0	Duke, 1992 *
Podophyllum hexandrum	Rhizome	not available	not available	not available	Duke, 1992 *
Podophyllum peltatum	Plant	not available	not available	not available	Duke, 1992 *
Sanguinaria canadensis	Root	not available	not available	not available	Duke, 1992 *
Xanthorhiza simplicissima	Root	12000.0	13000.0	-0.8	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Zanthoxylum alatum	Bark	not available	not available	not available	ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
Zanthoxylum americanum	Plant	not available	not available	not available	Duke, 1992 *
Zanthoxylum clava-herculis	Plant	not available	not available	not available	Duke, 1992 *
Zanthoxylum clava-herculis	Bark	not available	not available	not available	Duke, 1992 *