Chemical BERBERINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

BERBERINE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
(+)-Inotropic	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Abortifacient	not available	Duke, 1992 *
Adrenolytic	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Amebicide	200 ug/ml	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Amebicide	EC83=100 ug/ml orl rat	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Analgesic	not available	Duke, 1992 *
Anesthetic	not available	Duke, 1992 *
Antiacetylcholinesterase	not available	Duke, 1992 *
Antiacne	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Antiadrenergic	not available	Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Antiaggregant	not available	Duke, 1992 *
Antialzheimeran	not available	Duke, 1992 *
Antiamnesic	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Antiangiogenic	not available	Duke, 1992 *
Antiarrhythmic	not available	Duke, 1992 *
Antiarthritic	not available	Duke, 1992 *
Antibacillus	MIC=200 ug/ml	Duke, 1992 *
Antibacterial	12.5-2,500 ug/ml	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antibacterial	100 mg/4x/day	Duke, 1992 *
Antibacterial	MIC=6-630 ug/ml	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Mahonia repens	Root	not available	1417.0	-1.2	Duke, 1992 *
Mahonia siamensis	Stem Bark	not available	2000.0	-1.0	Ruangrungsi, N., De-Eknamkul, W., Lange, G. L. 1984. Studies on Thai Medicinal Plant. Part I. Planta Medica, 50(5): 432-433.
Menispermum canadense	Plant	not available	not available	not available	Duke, 1992 *
Nandina domestica	Plant	not available	not available	not available	Duke, 1992 *
Papaver somniferum	Plant	not available	not available	not available	Father Nature's Farmacy: The aggregate of all these three-letter citations.
Phellodendron amurense	Bark	8300.0	10000.0	-1.0	Duke, 1992 *
Podophyllum hexandrum	Rhizome	not available	not available	not available	Duke, 1992 *
Podophyllum peltatum	Plant	not available	not available	not available	Duke, 1992 *
Sanguinaria canadensis	Root	not available	not available	not available	Duke, 1992 *
Xanthorhiza simplicissima	Root	12000.0	13000.0	-0.8	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Zanthoxylum alatum	Bark	not available	not available	not available	ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
Zanthoxylum americanum	Plant	not available	not available	not available	Duke, 1992 *
Zanthoxylum clava-herculis	Plant	not available	not available	not available	Duke, 1992 *
Zanthoxylum clava-herculis	Bark	not available	not available	not available	Duke, 1992 *