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Chemical ID
CARNOSOL
Ubiquitous
No
| Activity | Dosage | Reference |
|---|---|---|
| 5-Lipoxygenase-Inhibitor | IC50 (uM)=2 | Duke, 1992 * |
| Antibiotic | not available | Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. |
| Antihepatotoxic | not available | Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. |
| AntiHIV | not available | J. Nat. Prod. 56: 1426. |
| Antiinflammatory | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Antilipoperoxidant | not available | Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. |
| Antimutagenic | not available | Economic & Medicinal Plant Research, 6: 235. |
| Antioxidant | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Antiradicular | not available | Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. |
| Antitumor | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Antitumor-Promoter | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Cancer-Preventive | not available | Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. |
| Candidicide | not available | Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. |
| Cyclooxygenase-Inhibitor | IC50 (uM) =16 | Duke, 1992 * |
| Fungicide | not available | Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. |
| Metal-Chelator | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Ornithine-Decarboxylase-Inhibitor | not available | McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. |
| Pesticide | not available | Duke, 1992 * |
| Protease-Inhibitor | not available | J. Nat. Prod. 56: 1426. |
| Quinone-Reductase-Inducer | 100 mg/kg ipr rat | Singletary, K. W. 1996. Rosemary Extract and Carnosol Stimulate Rat Liver Glutathione-s-transferase and Quinone Reductase Activities. Cancer Lett., 100: 139-144. |
| Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
|---|---|---|---|---|---|
| Hyptis dilatata | Shoot | not available | 2963.0 | 1.0 | Urones, J. G., Marcos, I. S., Diez, D., Cubilla, L. 1998. Tricyclic Diterpenes from Hyptis dilatata. Phytochemistry, 486: 1935-1938. |
| Isodon grandifolius | Leaf | not available | 448.0 | -0.6 | Wu, S. H., Zhang, H. J., Lin, Z. W., Sun, H. D. 1993. Terpenoids from Isodon grandifolia var. atuntzensis. Phytochemistry, 344: 1176-1178. |
| Lepechinia hastata | Shoot | not available | 4190.0 | 1.7 | Encarnacion-Dimayuga, R., Almada, G., Virgen, M. 1998. Minimum Antimicrobial Inhibitory Concentration of Carnosol and of the Ethanol Extract from Lepichinia hastata. Phytomedicine, 54: 301-305. |
| Lepechinia urbanii | Shoot | not available | not available | not available | Ahmed, A. A., Hussein, N. S., De Adams, A. A., Mabry, T. J. 1995. Abietane Diterpenes from Lepechinia urbaniana. Pharmazie, 504: 279-280. |
| Podocarpus koordersii | Wood | not available | 3.7 | not available | Cambie, R. C., Cox, R. E., Sidwell, D. 1984. Phenolic Diterpenoids of Podocarpus ferrugineus and other Podocarps. Phytochemistry, 232: 333-336. |
| Rosmarinus officinalis | Shoot | not available | not available | not available | Pearson, D. A., Frankel, E. N., Aeschbach, R., German, J. B. 1997. Inhibition of Endothelial Cell-Mediated Oxidation of Low-Density Lipoprotein by Rosemary and Plant Phenolics. J. Agri. & Food Chemistry, 453: 578-582. |
| Rosmarinus officinalis | Leaf | 530.0 | 46000.0 | 1.7 | Duke, 1992 * |
| Salvia africana-lutea | Shoot | not available | 556.0 | -0.6 | Bisio, A., Fontana, N., Romussi, G., De Tommasi, N. 1998. Diterpenes and Triterpenes from Salvia aurea L. Part 2. Constituents of Labiatae. Pharmazie, 533: 210-211. |
| Salvia canariensis | Plant | not available | 157.0 | not available | Luis, J. G., Gonzalez, A. G., Andres, L. S., Mederos, S. 1992. Diterpenes from in vitro-Grown Salvia canariensis. Phytochemistry, 31(9): 3272-3273. |
| Salvia canariensis | Flower | not available | not available | not available | Duke, 1992 * |
| Salvia chinopeplica | Leaf | not available | 83.0 | -0.6 | Amaro-Luis, J. M., Herrera, J. R., Luis, J. G. 1998. Abietane Diterpenoids from Salvia chinopeplica. Phytochemistry, 47(5): 895-897. |
| Salvia columbariae | Shoot | not available | 156.0 | -0.9 | Luis, J. G., Quinones, W., Grillo, T. A., Kishi, M. P. 1994. Diterpenes from the Aerial Part of Salvia columbariae. Phytochemistry, 35(5): 1373-1374. |
| Salvia mellifera | Shoot | not available | 1017.0 | -0.3 | Duke, 1992 * |
| Salvia munzii | Shoot | not available | not available | not available | Luis, J. G., Grillo, T. A. 1993. Abietane Diterpenes from Salvia munzii. Phytochemistry, 34(3): 863-864. |
| Salvia officinalis | Leaf | not available | 1660.0 | -0.5 | Duke, 1992 * |
| Salvia officinalis | Plant | not available | not available | not available | Duke, 1992 * |
| Salvia officinalis | Shoot | not available | 34.0 | -0.9 | Duke, 1992 * |
| Salvia officinalis | Resin, Exudate, Sap | not available | 36000.0 | not available | Duke, 1992 * |