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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
HYPEROSIDE Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
INDOLE *
IRIDINE IC21=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ISOCHLOROGENIC-ACID-A 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOCHLOROGENIC-ACID-B 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOFRAXIDIN 10 ug/ml cow (weak activity, 18% inhibition) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ISOLIQUIRITIGENIN 0.1 ug/ml *
ISOLIQUIRITIGENIN IC50=0.32 uM *
ISOLIQUIRITIN IC50=0.72 uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
ISOQUERCITRIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ISOSCOPOLETIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
JIOCAROTENOSIDE-A-1 Sasaki, H., Nishimura, H., Morota, T., Katshara, T., Zhengxiong, C., Mitsuhashi, H. 1991. Norcarotenoid Glycosides of Rehmannia glutinosa var. purpurea. Phytochemistry, 30(5): 1639-1644.
JIONOSIDE IC50=0.51uM *
JUGLANIN IC65=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
KAEMPFEROL-3-RHAMNOSIDE IC43=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL-3-RHAMNOSIDE IC85=10 uM *
KAEMPFEROL=3=NEOHESPERIDOSIDE IC30=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KOLAVIRON IC50= 5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
KOLAVIRON IC50=5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Albizia procera 1 0
Aleurites fordii Tungoil Tree 2 0
Aleurites moluccana Candlenut; Candleberry; Candlenut Tree; Indian Walnut; Lumbangtree; Varnishtree 1 0
Alisma plantago-aquatica Mud Plantain; Tse-Hsieh; Water Plantain; Ze-Xie 3 0
Alliaria petiolata Garlic Mustard 1 0
Allium ampeloprasum Elephant Garlic; Kurrat 6 13, 254
Allium cepa Onion; Shallot 9 496, 520
Allium sativum var. sativum Garlic 9 10, 217
Allium schoenoprasum Chives 5 9, 987.5
Alnus glutinosa Black Alder 2 0
Alocasia macrorrhiza Giant Taro 1 622
Aloe spp. Aloe 1 6, 260
Aloe vera Bitter Aloes; Aloe 5 12, 520
Aloysia citrodora Lemon Verbena 10 448
Alpinia galanga Greater Galangal; Siamese Ginger; Languas 4 5, 827, 932
Alpinia officinarum Lesser Galangal; Chinese Ginger 4 0
Althaea officinalis Marshmallow; White Mallow 18 6, 560
Amaranthus sp. Pigweed 2 6, 263
Amaranthus spinosus Spiny pigweed 2 5, 030
Ammi majus Bishop's Weed 4 0