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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ASTRAGALIN IC30=1 uM *
ASTRAGALIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AURANTIOBTUSIN IC50=13.6 uM *
AVICULARIN IC32=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AVICULARIN IC84=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AXILLARIN IC80=0.1 uM *
AXILLARIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
BAICALEIN IC50=0.98 ppm Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALEIN IC50=0.98 rbt Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALEIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BAICALIN IC50=13.6 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
BAICALIN IC42=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BERBERINE-CHLORIDE IC100=14 nM *
BERBERINE-IODIDE IC100=33 nM *
BERBERINE-SULFATE IC100=13.5 nM *
BRAZILIN ED50=100 uM *
BREVIFOLIN-CARBOXYLIC-ACID IC50=2.4 uM Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
CAFFEIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
CAPILLARISIN 10 uM rat Yamaguchi, T., Ueda, T., Sata, S., Mihashi, H. 1989. Aldose Reductase Inhibitors for Treatment of Diabetic Diseases. Patent, Japan Kokai Tokkyo Koho-01 228,914. 5pp.
CAPILLARISIN IC50=0.22 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Phaseolus spp 1 0
Phaseolus vulgaris Black Bean; Green Bean; Haricot Bean; Garden Bean; String Bean; Dwarf Bean; Field Bean; Flageolet Bean; French Bean; Kidney Bean; Navy Bean; Pop Bean; Popping Bean; Snap Bean; Wax Bean; Haricot Vert; Haricot 8 256, 786.69997406006
Phellodendron amurense Huang Po; Po Mu; Amur Cork Tree; Huang Bai 2 0
Phoenix dactylifera Date Palm 5 750
Phragmites australis Common Reed; Ditch Reed; Giant Reed; Reed Grass 1 36, 400
Phyllanthus acidus Indian Gooseberry; Otaheite Gooseberry 1 2, 558
Phyllanthus amarus 2 2, 878
Phyllanthus emblica Emblic; Myrobalan 6 283, 006
Phyllanthus niruri Seed On The Leaf 5 0
Physalis alkekingi Bladderherb; Lantern 2 8, 000
Physalis ixocarpa Tomatillo 1 460
Physalis peruviana Cape Gooseberry; Ground Cherry 4 5, 730
Phytolacca americana Pokeweed 4 16, 184
Picea mariana Black Spruce 1 161
Picrorhiza kurrooa Picrorhiza 1 1, 000
Pilocarpus jaborandi Indian Hemp; Pernambuco Jaborandi 1 50
Pilocarpus microphyllus Maranhao Jaborandi 2 640
Pimenta dioica Allspice; Jamaica-Pepper; Pimenta; Clover-Pepper; Pimento 9 24, 130
Pimenta racemosa Bayrum Tree; West Indian Bay 5 49, 362
Pimpinella anisum Anise; Sweet Cumin 14 75, 194