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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
TRIFOLIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
TRIFOLIN IC19=1 uM *
UMBELLIFERONE IC50=4.8 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID 100 uM/l *
VERBASCOSIDE IC50=0.39-15.1 uM *
VITEXICARPIN 100 uM/l *
VITEXIN 5 ug/ml Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
VITEXIN IC15=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WARANGALONE 10 uM Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN IC13=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN IC50=48 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE IC50=40 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER IC50=39 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Isatis tinctoria Dyer's Woad 2 0
Jasminum officinale Jasmine; Poet's Jessamine 4 570
Jatropha curcas Physic Nut; Purging Nut 1 0
Jatropha gossypifolia Spanish Physic Nut 1 0
Juglans nigra Black Walnut 6 70
Juglans regia English Walnut 11 37, 354.5
Juncus effusus Rush 1 0
Juniperus communis Common Juniper; Juniper 21 11, 600
Juniperus macropoda Himalayan Juniper; Indian Juniper 1 0
Juniperus sabina Sabine 3 0
Juniperus virginiana Red Cedar 2 0
Justicia pectoralis Angel Of Death; Bolek Hena; Curia 3 5, 601
Kalanchoe pinnata Air Plant; Siempre Viva 4 0
Kalanchoe spathulata Beach Bells 2 0
Kalmia latifolia Mountain Laurel; Calico Bush; Spoonwood 1 0
Kennedia coccinea 1 49
Kennedia nigricans 1 24
Kennedia procurrens 1 33
Kennedia rubicunda 1 25
Lablab purpureus Bonavist Bean; Hyacinth Bean; Lablab Bean 1 3, 379.7999954223633