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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
PROTOPINE IC50=38.5 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
PRUNASIN 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PUERARIN *
QUERCETAGETIN IC29=1 uM *
QUERCETAGETIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCETIN 100 uM *
QUERCETIN 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
QUERCETIN IC50=0.84 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
QUERCETIN IC50=0.344 uM Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.
QUERCIMERITRIN IC20=1 uM *
QUERCIMERITRIN IC44=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
QUERCITRIN IC50=64 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
QUERCITRIN IC55=0.1 uM *
QUERCITRIN IC50=2 uM Terashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
QUERCITRIN IC55=0.15 uM *
QUERCITRIN 0.1-100 uM *
QUERCITRIN 0.5-4 ug/ml *
QUERCITRYL-2'-ACETATE IC87=0.1uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
RESORCINOL 909.1 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
REYNOUTRIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Phaseolus spp 1 0
Phaseolus vulgaris Black Bean; Green Bean; Haricot Bean; Garden Bean; String Bean; Dwarf Bean; Field Bean; Flageolet Bean; French Bean; Kidney Bean; Navy Bean; Pop Bean; Popping Bean; Snap Bean; Wax Bean; Haricot Vert; Haricot 8 256, 786.69997406006
Phellodendron amurense Huang Po; Po Mu; Amur Cork Tree; Huang Bai 2 0
Phoenix dactylifera Date Palm 5 750
Phragmites australis Common Reed; Ditch Reed; Giant Reed; Reed Grass 1 36, 400
Phyllanthus acidus Indian Gooseberry; Otaheite Gooseberry 1 2, 558
Phyllanthus amarus 2 2, 878
Phyllanthus emblica Emblic; Myrobalan 6 283, 006
Phyllanthus niruri Seed On The Leaf 5 0
Physalis alkekingi Bladderherb; Lantern 2 8, 000
Physalis ixocarpa Tomatillo 1 460
Physalis peruviana Cape Gooseberry; Ground Cherry 4 5, 730
Phytolacca americana Pokeweed 4 16, 184
Picea mariana Black Spruce 1 161
Picrorhiza kurrooa Picrorhiza 1 1, 000
Pilocarpus jaborandi Indian Hemp; Pernambuco Jaborandi 1 50
Pilocarpus microphyllus Maranhao Jaborandi 2 640
Pimenta dioica Allspice; Jamaica-Pepper; Pimenta; Clover-Pepper; Pimento 9 24, 130
Pimenta racemosa Bayrum Tree; West Indian Bay 5 49, 362
Pimpinella anisum Anise; Sweet Cumin 14 75, 194