Cornus mas | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Cornelian Cherry, Sorbet

How used

Medicinal

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Activities: 296

Chemicals w/Activities: 16

All Chemicals: 22

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
51	ELLAGIC-ACID	Flower	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
Abortifacient 1.2 mg/kg ivn mus * ACE-Inhibitor IC50=5 mM/l * Aldose-Reductase-Inhibitor IC50=0.2 ug/ml (strong activity) * Aldose-Reductase-Inhibitor IC50=0.2 uM * Antiaflatoxin * Antianaphylactic * Antibacterial 1,250 ug/ml * Antibacterial ID50=20 ug/ml * Anticancer (Cervix) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Colon) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Esophagus) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Mouth) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticariogenic ID50=20 ug/ml * Anticataract Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989. Antigingivitic 1,250 ug/ml * AntiGTF ID50=20 ug/ml * AntiHIV IC90=200 ug/ml Tan, G.T., Pezzuto, J.M., Kinghorn,* A.D., Hughes, S.H. Evaluation Of Natural Products As Inhibitors Of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. Journal of Natural Products, 54(1): 143-154, 1991. Antihyperthyroid * Antiinflammatory * Antimalarial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antimutagenic * Antioxidant 2/3 quercetin * Antioxidant >50 x tocopherol Osawa, T. Phenolic Antioxidants in Dietary Plants as Antimutagens.Phenolic Compounds in Food and Their Effects on Health, Ch.11 p.142. Antioxidant IC98=30 ppm * Antiperiodontic 1,250 ug/ml * Antiperoxidant IC50=29 uM Planta Medica, 57: A54, 1991. Antiplaque 1,250 ug/ml * Antiplasmodial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antiseptic 1,250 ug/ml * Antistreptococcic ID50=20 ug/ml * Antithyroid Jim Duke's personal files. Antitumor * Antiviral Economic & Medicinal Plant Research, 5: 224. Antiyeast IC50=10.5 uM * Apoptotic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Astringent Martindale's 29th Cancer-Preventive 3 ppm * Candida-SAP-Inhibitor IC50=8.4 uM * Cytotoxic 4.6 ug/ml Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 359. Deiodinase-Inhibitor Jim Duke's personal files. Detoxicant * Glucosyl-Transferase-Inhibitor ID50=20 ug/ml * Hemostatic Merck 11th Edition Hepatoprotective IC55=30 ug/ml Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990. HIV-RT-Inhibitor Economic & Medicinal Plant Research, 5: 224. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Pesticide * Quinone-Reductase-Inducer 0.4 g/kg rat Ahn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828. Sunscreen 0.50% Jim Duke's personal files. Topoisomerase-I-Antagonist Journal of Medicinal Food 2: 167.1999. Xanthine-Oxidase-Inhibitor IC50=3.1 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
51	ELLAGIC-ACID	Leaf	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
Abortifacient 1.2 mg/kg ivn mus * ACE-Inhibitor IC50=5 mM/l * Aldose-Reductase-Inhibitor IC50=0.2 ug/ml (strong activity) * Aldose-Reductase-Inhibitor IC50=0.2 uM * Antiaflatoxin * Antianaphylactic * Antibacterial 1,250 ug/ml * Antibacterial ID50=20 ug/ml * Anticancer (Cervix) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Colon) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Esophagus) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Mouth) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticariogenic ID50=20 ug/ml * Anticataract Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989. Antigingivitic 1,250 ug/ml * AntiGTF ID50=20 ug/ml * AntiHIV IC90=200 ug/ml Tan, G.T., Pezzuto, J.M., Kinghorn,* A.D., Hughes, S.H. Evaluation Of Natural Products As Inhibitors Of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. Journal of Natural Products, 54(1): 143-154, 1991. Antihyperthyroid * Antiinflammatory * Antimalarial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antimutagenic * Antioxidant 2/3 quercetin * Antioxidant >50 x tocopherol Osawa, T. Phenolic Antioxidants in Dietary Plants as Antimutagens.Phenolic Compounds in Food and Their Effects on Health, Ch.11 p.142. Antioxidant IC98=30 ppm * Antiperiodontic 1,250 ug/ml * Antiperoxidant IC50=29 uM Planta Medica, 57: A54, 1991. Antiplaque 1,250 ug/ml * Antiplasmodial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antiseptic 1,250 ug/ml * Antistreptococcic ID50=20 ug/ml * Antithyroid Jim Duke's personal files. Antitumor * Antiviral Economic & Medicinal Plant Research, 5: 224. Antiyeast IC50=10.5 uM * Apoptotic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Astringent Martindale's 29th Cancer-Preventive 3 ppm * Candida-SAP-Inhibitor IC50=8.4 uM * Cytotoxic 4.6 ug/ml Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 359. Deiodinase-Inhibitor Jim Duke's personal files. Detoxicant * Glucosyl-Transferase-Inhibitor ID50=20 ug/ml * Hemostatic Merck 11th Edition Hepatoprotective IC55=30 ug/ml Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990. HIV-RT-Inhibitor Economic & Medicinal Plant Research, 5: 224. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Pesticide * Quinone-Reductase-Inducer 0.4 g/kg rat Ahn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828. Sunscreen 0.50% Jim Duke's personal files. Topoisomerase-I-Antagonist Journal of Medicinal Food 2: 167.1999. Xanthine-Oxidase-Inhibitor IC50=3.1 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
62	GALLIC-ACID	Flower	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
ACE-Inhibitor IC50=7.7 mM/l * Analgesic * Antiadenovirus Economic & Medicinal Plant Research, 5: 194. Antiallergenic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Antianaphylactic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiangiogenic * Antiasthmatic Watt, J.M., and Breyer-Brandwijk, M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 1962. Antibacterial MIC=1,000 ug/ml * Antibronchitic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Anticancer * Anticarcinomic ED50=3 * Antiescherichic * Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antiflu Economic & Medicinal Plant Research, 5: 194. Antihepatotoxic Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Antiherpetic EC50=>10 ug/ml * AntiHIV * Antiinflammatory Kroes, B.H., et al. 1991. Anti-Inflammatory Activity of Gallic Acid. Planta Medica, 58(6): 499. Antileishmanic EC50=4.4 ug/ml * AntiMRSA * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antinitrosaminic * Antioxidant 7 x quercetin * Antioxidant IC44=33 ppm * Antioxidant 2/3 BHA * Antiperiodontitic 10 ug/ml * Antiperoxidant IC50=69 uM * Antipolio Economic & Medicinal Plant Research, 5: 194. Antiproteolytic 10 ug/ml * Antiradicular 7 x quercetin * Antiradicular IC50=4.9 uM * Antiseptic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic MIC=1,000 ug/ml * Antitumor * Antitumor-Promoter * Antiviral * Apoptotic * Astringent Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Bacteristat Lamikanra, A., Ogundaini, A.O., and Ogungbamila, F.O. Antibacterial Constituents of Alchornea cordifolia Leaves. Phytotherapy Research 4(5): 198. Bronchodilator Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Carcinogenic * Choleretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cyclooxygenase-Inhibitor * Cytotoxic 500 uM * Floral-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Gram(+)icide MIC=1,000 ug/ml * Gram(-)icide MIC=1,000 ug/ml * Hemostat * Hepatoprotective Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Immunomodulator * Immunostimulant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Immunosuppressant * Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Nephrotoxic Martindale's 29th NO-Inhibitor IC-26=250 uM * Pesticide * Styptic * Topoisomerase-I-Inhibitor Hamada, S. I., Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. 1997. Immunosuppressive Effects by Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity. Biol Pharm Bull, 20: 1017-1019. Xanthine-Oxidase-Inhibitor IC50=24 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
62	GALLIC-ACID	Leaf	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
ACE-Inhibitor IC50=7.7 mM/l * Analgesic * Antiadenovirus Economic & Medicinal Plant Research, 5: 194. Antiallergenic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Antianaphylactic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiangiogenic * Antiasthmatic Watt, J.M., and Breyer-Brandwijk, M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 1962. Antibacterial MIC=1,000 ug/ml * Antibronchitic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Anticancer * Anticarcinomic ED50=3 * Antiescherichic * Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antiflu Economic & Medicinal Plant Research, 5: 194. Antihepatotoxic Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Antiherpetic EC50=>10 ug/ml * AntiHIV * Antiinflammatory Kroes, B.H., et al. 1991. Anti-Inflammatory Activity of Gallic Acid. Planta Medica, 58(6): 499. Antileishmanic EC50=4.4 ug/ml * AntiMRSA * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antinitrosaminic * Antioxidant 7 x quercetin * Antioxidant IC44=33 ppm * Antioxidant 2/3 BHA * Antiperiodontitic 10 ug/ml * Antiperoxidant IC50=69 uM * Antipolio Economic & Medicinal Plant Research, 5: 194. Antiproteolytic 10 ug/ml * Antiradicular 7 x quercetin * Antiradicular IC50=4.9 uM * Antiseptic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic MIC=1,000 ug/ml * Antitumor * Antitumor-Promoter * Antiviral * Apoptotic * Astringent Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Bacteristat Lamikanra, A., Ogundaini, A.O., and Ogungbamila, F.O. Antibacterial Constituents of Alchornea cordifolia Leaves. Phytotherapy Research 4(5): 198. Bronchodilator Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Carcinogenic * Choleretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cyclooxygenase-Inhibitor * Cytotoxic 500 uM * Floral-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Gram(+)icide MIC=1,000 ug/ml * Gram(-)icide MIC=1,000 ug/ml * Hemostat * Hepatoprotective Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Immunomodulator * Immunostimulant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Immunosuppressant * Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Nephrotoxic Martindale's 29th NO-Inhibitor IC-26=250 uM * Pesticide * Styptic * Topoisomerase-I-Inhibitor Hamada, S. I., Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. 1997. Immunosuppressive Effects by Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity. Biol Pharm Bull, 20: 1017-1019. Xanthine-Oxidase-Inhibitor IC50=24 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	HEXAHYDROXYDIPHENIC-ACID	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
75	KAEMPFEROL	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
11B-HSD-Inhibitor * 5-Lipoxygenase-Inhibitor IC50 (uM)=20 * Aldose-Reductase-Inhibitor 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213. Antiaflatoxin IC50=3.28 ppm * Antiaflatoxin IC50=8.73 uM * Antiaggregant 30 uM * Antiallergic * Antibacterial 20 ug/ml * Anticancer * Antifertility 250 mg/kg/day/60 days/orl rat Kumar, P., Dixit, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989. Antigingivitic 20 ug/ml Antiherpetic 23-92 ug/ml Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992. Antihistaminic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antiimplantation * Antiinflammatory 20 mg/kg * Antiinflammatory 200 mg/kg ipr rat * Antileukemic IC50=3.1 ug/ml Life Sciences 55: 1061. Antilymphocytic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant 3/4 quercetin * Antioxidant IC50=1.2 ug/ml * Antioxidant IC50=40 uM * Antiperiodontic 20 ug/ml * Antiplaque 20 ug/ml * Antiradicular 7 x quercetin * Antiseptic 20 ug/ml * Antiserotonin 200 mg/kg ipr rat * Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic * Antitumor * Antitumor-Promoter Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990. Antiulcer 50-200 mg/kg ipr rat * Antiviral 23-92 ug/ml * Apoptotic 60 uM * Aromatase-Inhibitor IC12=1 uM/l Journal of Medicinal Food 2: 235.1999. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp. Choleretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Copper-Chelator * COX-2-Inhibitor * Cyclooxygenase-Inhibitor IC50 (uM) =20 * Cytotoxic * Diaphoretic? Lawrence Review of Natural Products, Dec-90. Diuretic * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Estrogenic EC50=0.56 uM * Fungicide 20 ug/ml Father Nature's Farmacy: The aggregate of all these three-letter citations. Hepatoprotective IC50=5.46 uM * Hepatoprotective IC50=1.30 ppm * HIV-RT-Inhibitor IC50=50-150 ug/ml Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991. Hypotensive * ICAM-1-Inhibitor * iNOS-Inhibitor IC50=<15 uM * iNOS-Inhibitor IC50=13.9 uM * Inotropic * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. JNK-Inhibitor * Lipoxygenase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. MAO-Inhibitor * Mutagenic * Natriuretic * Neuroprotective * NO-Inhibitor IC50=13.9 uM * PAF-Inhibitor * Pesticide * Protisticide Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105. Quinone-Reductase-Inducer 3 uM * Teratologic * TNF-alpha-Inhibitor IC50=3.99 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC50=8.1 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225. Tyrosinase-Inhibitor ID50=230 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator *
27	LINOLEIC-ACID	Seed Oil	--	--	--	Hohn, M. E., Meinschein, W. G. 1976. Seed Oil Fatty Acids: Evolutionary Significance in the Nyssaceae and Cornaceae. Biochem. Syst. Ecol., 4: 193-199.
5-Alpha-Reductase-Inhibitor * Antiacne * Antialopecic * Antianaphylactic Economic & Medicinal Plant Research, 6: 189. Antiandrogenic * Antiarteriosclerotic * Antiarthritic Economic & Medicinal Plant Research, 6: 189. Anticoronary Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antieczemic Economic & Medicinal Plant Research, 6: 189. Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antigranular * Antihistaminic Economic & Medicinal Plant Research, 6: 189. Antiinflammatory IC50=31 uM * Antileukotriene-D4 IC50=31 uM * Antimenorrhagic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). AntiMS Economic & Medicinal Plant Research, 6: 189. Antiprostatitic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic Science News, 146: 421. Comedolytic * Hepatoprotective * Hypocholesterolemic Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.) Immunomodulator Economic & Medicinal Plant Research, 6: 189. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Metastatic Science News, 146: 421. Nematicide Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Propecic *
27	LINOLEIC-ACID	Seed	--	687000.0	4.97	Kleiman, R., Spencer, G. F. 1982. Search for New Industrial Oils: 16. Umbelliflorae-Seed Oils Rich in Petroselinic Acid. J. Amer. Oil Chem. Soc., 59: 29-32.
5-Alpha-Reductase-Inhibitor * Antiacne * Antialopecic * Antianaphylactic Economic & Medicinal Plant Research, 6: 189. Antiandrogenic * Antiarteriosclerotic * Antiarthritic Economic & Medicinal Plant Research, 6: 189. Anticoronary Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antieczemic Economic & Medicinal Plant Research, 6: 189. Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antigranular * Antihistaminic Economic & Medicinal Plant Research, 6: 189. Antiinflammatory IC50=31 uM * Antileukotriene-D4 IC50=31 uM * Antimenorrhagic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). AntiMS Economic & Medicinal Plant Research, 6: 189. Antiprostatitic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic Science News, 146: 421. Comedolytic * Hepatoprotective * Hypocholesterolemic Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.) Immunomodulator Economic & Medicinal Plant Research, 6: 189. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Metastatic Science News, 146: 421. Nematicide Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Propecic *
0	LINOLENIC-ACID	Seed	--	15000.0	-0.32	Kleiman, R., Spencer, G. F. 1982. Search for New Industrial Oils: 16. Umbelliflorae-Seed Oils Rich in Petroselinic Acid. J. Amer. Oil Chem. Soc., 59: 29-32.
0	LINOLENIC-ACID	Seed Oil	--	--	--	Hohn, M. E., Meinschein, W. G. 1976. Seed Oil Fatty Acids: Evolutionary Significance in the Nyssaceae and Cornaceae. Biochem. Syst. Ecol., 4: 193-199.
0	MORRONOSIDE	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
18	OLEIC-ACID	Seed	--	160000.0	0.34	Kleiman, R., Spencer, G. F. 1982. Search for New Industrial Oils: 16. Umbelliflorae-Seed Oils Rich in Petroselinic Acid. J. Amer. Oil Chem. Soc., 59: 29-32.
5-Alpha-Reductase-Inhibitor * Allergenic * Alpha-Reductase-Inhibitor * Anemiagenic * Antialopecic * Antiandrogenic * Antiinflammatory IC50=21 uM * Antileukotriene-D4 IC50=21 uM * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic 5 ml/man * Dermatitigenic * FLavor FEMA 1-30 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.) Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Merck 11th Edition Percutaneostimulant Seki, T., Toeda, C., Kawaguchi, T., Juni, K., Sugibayashi, K., and Morimoto, Y. 1990. Enhanced Transdermal Delivery of Zidovudine in Rats and Human Skin. Chem. Pharm. Bull. 38(11): 3086-3089, 1990. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Propecic *
18	OLEIC-ACID	Seed Oil	--	--	--	Hohn, M. E., Meinschein, W. G. 1976. Seed Oil Fatty Acids: Evolutionary Significance in the Nyssaceae and Cornaceae. Biochem. Syst. Ecol., 4: 193-199.
5-Alpha-Reductase-Inhibitor * Allergenic * Alpha-Reductase-Inhibitor * Anemiagenic * Antialopecic * Antiandrogenic * Antiinflammatory IC50=21 uM * Antileukotriene-D4 IC50=21 uM * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic 5 ml/man * Dermatitigenic * FLavor FEMA 1-30 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.) Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Merck 11th Edition Percutaneostimulant Seki, T., Toeda, C., Kawaguchi, T., Juni, K., Sugibayashi, K., and Morimoto, Y. 1990. Enhanced Transdermal Delivery of Zidovudine in Rats and Human Skin. Chem. Pharm. Bull. 38(11): 3086-3089, 1990. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Propecic *
0	PLAMITIC-ACID	Seed Oil	--	--	--	Hohn, M. E., Meinschein, W. G. 1976. Seed Oil Fatty Acids: Evolutionary Significance in the Nyssaceae and Cornaceae. Biochem. Syst. Ecol., 4: 193-199.
11	PROCYANIDIN	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
Antiallergic * Antibacterial * Antibiotic * Antiedemic * Antiexudative * AntiHIV * Antiviral * Capillariprotective * Hyaluronidase-Inhibitor * Pesticide * Xanthine-Oxidase-Inhibitor IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
176	QUERCETIN	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
11B-HSD-Inhibitor * 5-Lipoxygenase-Inhibitor IC50 (uM)=4 * Aldehyde-Oxidase-Inhibitor IC70-96=10 uM * Aldose-Reductase-Inhibitor 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Aldose-Reductase-Inhibitor IC50=0.84 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387 Aldose-Reductase-Inhibitor IC50=0.344 uM Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624. Aldose-Reductase-Inhibitor 100 uM * Allelochemic IC82=1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Allergenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Analgesic * Antiaflatoxin IC50=25 uM * Antiaflatoxin IC50=7.5 ppm * Antiaggregant IC50=55 uM Economic & Medicinal Plant Research, 5: 333. Antiaggregant 30 uM * Antiaging * Antiallergic IC50=14 uM Jim Duke's personal files. Antialzheimeran * Antianaphylactic Meli, R., Autore, G., Di Carlo, G., Capasso, F. Inhibitory Action of Quercetin on Intestinal Transit in Mice. Phytotherapy Research 4(5): 201, 1990. Antiangiogenic * Antiarthritic * Antiasthmatic IC50=14 uM * Antiatherosclerotic * Antibacterial Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic (Breast) IC50=1.5 uM Medline (post 1990 searches filed in my computer) Anticariogenic ID50=120 ug/ml * Anticataract * Anticolitic 400 mg/man/3x/day Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticomplementary * AntiCrohn's 400 mg/man/3x/day Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticystitic 1,000 mg/day/4 weeks * Antidepressant * Antidermatitic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antidiabetic * Antielastase IC50=0.8 ug/ml * Antiencephalitic Economic & Medicinal Plant Research, 5: 199. Antiescherichic * Antiestrogenic * Antifeedant IC52=<1,000 ppm diet Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antifibrosarcomic * Antiflu Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antigastric Rastitel'nye Resursy, 21: 85. Antigonadotropic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. AntiGTF ID50=120 ug/ml * Antihepatotoxic Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. Antiherpetic 48-150 ug/ml * Antihistaminic IC50=<10 uM * AntiHIV * Antihydrophobic Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antihypertensive Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiinflammatory 20-150 mg/kg Fitoterapia No.5-1990. Antileishmanic IC50=64 * Antileukemic IC50=10 uM Economic & Medicinal Plant Research, 5: 225. Antileukemic IC50=>10 ug/ml Life Sciences 55: 1061. Antileukemic 5.5-60 uM * Antileukotriene Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antilipoperoxidant IC67=50 * Antimalarial IC50=1-6.4 ug/ml Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987. Antimelanomic * Antimetastatic * Antimutagenic ID50=2-5 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antimutagenic ID50=0.62 ug/ml * Antimyocarditic Economic & Medicinal Plant Research, 5: 199. Antinitrosaminic * Antinociceptive * Antioxidant ED50=2.3 uM Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98. Antioxidant IC96=300 ppm Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant IC47=10 uM * Antioxidant 4.7 x Vit. E * Antipancreatitic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Antiperiodontal Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiperistaltic * Antipermeability * Antiperoxidant Planta Medica, 57: A110, 1991. Antipharyngitic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiplaque Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiplasmodial IC50=13-64 * AntiPMS 500 mg/2x/day/wmn Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antipodriac * Antipolio Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiproliferant 10 nM * Antiprostanoid * Antiprostatitic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Antipsoriac Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiradicular IC50=4.6 uM Planta Medica, 56(6): 695, 1990. Antispasmodic * Antistreptococcic ID50=120 ug/ml * Antithiamin Phenolic Compounds in Food and Their Effects on Health, 69. Antithrombic * Antitrypanosomic IC50=13 * Antitumor 10 uM * Antitumor (Bladder) * Antitumor (Breast) * Antitumor (Colon) * Antitumor (Lung) * Antitumor (Ovary) * Antitumor (Skin) 20 uM * Antitumor-Promoter Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiulcer * Antiviral 48-150 ug/ml Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992. Antiviral IC50=10 uM Economic & Medicinal Plant Research, 5: 225. Apoptotic 20-60 uM * ATPase-Inhibitor Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Bacteristat 10 mg/ml * Bradycardiac Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Calmodulin-Antagonist Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). cAMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide * Capillariprotective Merck 11th Edition Carcinogenic 40,000 ppm (diet) mus Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Catabolic * COMT-Inhibitor * Copper-Chelator * COX-2-Inhibitor <40 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A2-Inhibitor * Cytotoxic ED50=70 ug/ml Matsukawa, Y., et al. The Effect of Quercetin and Other Flavonoids on Cell Cycle Progresssion and Growth of Human Gastric Cancer Cells. Planta Medica, 56(6): 677, 1990. Cytotoxic IC82=100 ug/ml Planta Medica, 57: A113, 1991. Deiodinase-Inhibitor Jim Duke's personal files. Diaphoretic? Lawrence Review of Natural Products, Dec-90. Differentiator 5.5 uM * Estrogenic 10% genistein * Fungicide * Glucosyl-Transferase-Inhibitor ID50=120 ug/ml * Hemostat Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Hepatomagenic 5,000 ppm (diet) rat Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Hepatoprotective * HIV-RT-Inhibitor IC50=<1 ug/ml Nakane, H., Fukushima, M., and Ono, K. Differential Inhibition Of Reverse Transcriptase And Various DNA Polymerases By Digallic Acid And Its Derivatives. Journal of Natural Products, 53(5): 1234-1240, 1990. Hypoglycemic 100 mg/kg orl rat Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. iNOS-Inhibitor IC50=20 uM Inotropic * Insulinogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Juvabional Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Larvistat 8,000 ppm diet Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Lipoxygenase-Inhibitor IC11=1.25 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Lipoxygenase-Inhibitor IC50=0.1-5 uM * MAO-A-Inhibitor * Mast-Cell-Stabilizer * Metal-Chelator (Copper) Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98. Metalloproteinase-Inhibitor IC50=>42 uM * MMP-9-Inhibitor 20 uM * Mutagenic * NADH-Oxidase-Inhibitor * NEP-Inhibitor IC50=>42 uM * Neuroprotective 5-25 uM * NF-kB-Inhibitor * NO-Inhibitor IC>50=125 uM * NO-Inhibitor IC50=20 uM * NO-Synthase-Inhibitor 5-50 uM * Ornithine-Decarboxylase-Inhibitor <10 uM * P450-Inducer 5 uM Father Nature's Farmacy: The aggregate of all these three-letter citations. P450-Inhibitor 50-100 uM Father Nature's Farmacy: The aggregate of all these three-letter citations. Pesticide * PGE2-Inhibitor * Phospholipase-Inhibitor * Plasmodicide Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Proliferant * Prostaglandin-Synthesis-Inhibitor 40 ug/ml Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284. Protein-Kinase-C-Inhibitor Naim, M., Zehavi, U., Nagy, S., and Rouseff, R.L. Hydroxycinnamic Acids as Off-Flavor Precursors in Citrus Fruits and Their Products. Phenolic Compounds in Food and Their Effects on Health, Ch.14. PTK-Inhibitor 0.4-24 uM * Quinone-Reductase-Inducer 6 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Quinone-Reductase-Inducer 13 uM * Teratologic * TNF-alpha-Inhibitor IC50=3.11 uM * Topoisomerase-I-Inhibitor IC50=12.8 ug/ml * Topoisomerase-I-Inhibitor IC50=42 uM * Topoisomerase-II-Inhibitor IC50=1-6.9 ug/ml * Topoisomerase-II-Inhibitor IC50=23-40 uM * Tumorigenic 0.1% diet orl rat/yr Jim Duke's personal files. Tyrosinase-Inhibitor ID50=70 uM * Tyrosine-Kinase-Inhibitor Economic & Medicinal Plant Research, 6: 170. Vasodilator * VEGF-Inhibitor * Xanthine-Oxidase-Inhibitor IC50=10.6 ug/ml * Xanthine-Oxidase-Inhibitor 3.1 uM * Xanthine-Oxidase-Inhibitor IC50=>0.4 ug/ml Chem. & Pharm. Bull. 38: 1772.
87	RUTIN	Leaf	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
5-HT-Inhibitor * Aldehyde-Oxidase-Inhibitor IC27-52=10 uM * Aldose-Reductase-Inhibitor 100 uM * Aldose-Reductase-Inhibitor 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Allelochemic * Antiaggregant ED50=33 nmol/kg iv * Antiallergic * Antiapoplectic * Antiatherogenic * Antiatherosclerotic * Antibacterial Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticancer * Anticapillary-Fragility 20-100 mg orl man Merck 7th Ed. Anticataract * Anticlastogen * Anticonvulsant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. AntiCVI 270 mg/man/day * Antidementia Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antidiabetic Jin, G-Z., Yamagata, Y., and Tomita, K.-i. 1989. Structure of Rutin Pentamethanol. Chem. Pharm. Bull. 38(2): 297-300, 1990. Antiedemic 270 mg/day orl man * Antierythemic * Antifeedant * Antiglaucomic 60 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antihematuric * Antihemorrhoidal * Antihepatotoxic Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiherpetic Economic & Medicinal Plant Research, 5: 198. Antihistaminic * Antihypertensive Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiinflammatory 20 mg/kg * Antimalarial IC50=>100 ug/ml Khalid, S.A., Farouk, A., Geary*, T.G., and Jensen, J.B. 1985. Potential Antimalarial Candidates From African Plants: An In Vitro Approach Using Plasmodium falciparum. Journal of Ethnopharmacology, 15: 201-209, 1986. Antimelanomic * Antimetastatic * Antimutagenic ID50=2-5 nM * Antinephritic * Antinociceptive * Antioxidant IC54=10 uM * Antioxidant IC28=30 ppm * Antioxidant IC50=120 uM * Antiperoxidant IC50=10-20 uM * Antiplatelet * Antiproliferant 50-75 uM/l * Antiprotozoal * Antipurpuric * Antiradicular 9 x quercetin * Antispasmodic * Antisunburn * Antithrombogenic EC50=500 nM * Antithyroid IC50=68 uM * Antitrypanosomic 100 mg/kg Planta Medica, 57: A44, 1991. Antitumor * Antitumor-Promoter * Antiulcer * Antivaricose * Antiviral * Apoptotic 75 uM/l * cAMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Capillariprotective Merck 11th Edition Catabolic * Chemopreventive * Cytoprotective IC50=3 uM * Estrogenic? Economic & Medicinal Plant Research, 6: 189. Hemostat * Hepatomagenic 20,000 ppm (diet) rat Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Hepatoprotective 20 mg/kg rat * Hypocholesterolemic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Hypotensive Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Immunomodulator * Insecticide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insectiphile Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Larvistat IC95=4,000-8,000 ppm diet Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Lipoxygenase-Inhibitor IC75=2.5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Mutagenic Economic & Medicinal Plant Research, 6: 189. Myoprotective * Myorelaxant Economic & Medicinal Plant Research, 6: 189. Oviposition-Stimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. PAF-Inhibitor * Pesticide * Protisticide * Radioprotective * Sunscreen * Topoisomerase-II-Inhibitor IC50=1 ug/ml Bernard, F. X., Sable, S., Cameron, B., Provost, J., Desnottes, J. F., Crouzet, J., Blanche, F. 1997. Glycosylated Flavones as Selective Inhibitors of Topoisomerase IV. Antimicrobial Agents & Chemotherapy, 41: 992-998. Vasodilator * Vasopressor *
87	RUTIN	Flower	--	--	--	Delaveau, P., Paris, R. R. 1961. Concerning the Presence of Rutoside and Gallic Derivatives from the Flowers of Cornus mas and Preliminary Research with C. sanguinea. Bull Soc Chim Biol, 43: 661-666.
5-HT-Inhibitor * Aldehyde-Oxidase-Inhibitor IC27-52=10 uM * Aldose-Reductase-Inhibitor 100 uM * Aldose-Reductase-Inhibitor 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Allelochemic * Antiaggregant ED50=33 nmol/kg iv * Antiallergic * Antiapoplectic * Antiatherogenic * Antiatherosclerotic * Antibacterial Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticancer * Anticapillary-Fragility 20-100 mg orl man Merck 7th Ed. Anticataract * Anticlastogen * Anticonvulsant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. AntiCVI 270 mg/man/day * Antidementia Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antidiabetic Jin, G-Z., Yamagata, Y., and Tomita, K.-i. 1989. Structure of Rutin Pentamethanol. Chem. Pharm. Bull. 38(2): 297-300, 1990. Antiedemic 270 mg/day orl man * Antierythemic * Antifeedant * Antiglaucomic 60 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antihematuric * Antihemorrhoidal * Antihepatotoxic Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiherpetic Economic & Medicinal Plant Research, 5: 198. Antihistaminic * Antihypertensive Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiinflammatory 20 mg/kg * Antimalarial IC50=>100 ug/ml Khalid, S.A., Farouk, A., Geary*, T.G., and Jensen, J.B. 1985. Potential Antimalarial Candidates From African Plants: An In Vitro Approach Using Plasmodium falciparum. Journal of Ethnopharmacology, 15: 201-209, 1986. Antimelanomic * Antimetastatic * Antimutagenic ID50=2-5 nM * Antinephritic * Antinociceptive * Antioxidant IC54=10 uM * Antioxidant IC28=30 ppm * Antioxidant IC50=120 uM * Antiperoxidant IC50=10-20 uM * Antiplatelet * Antiproliferant 50-75 uM/l * Antiprotozoal * Antipurpuric * Antiradicular 9 x quercetin * Antispasmodic * Antisunburn * Antithrombogenic EC50=500 nM * Antithyroid IC50=68 uM * Antitrypanosomic 100 mg/kg Planta Medica, 57: A44, 1991. Antitumor * Antitumor-Promoter * Antiulcer * Antivaricose * Antiviral * Apoptotic 75 uM/l * cAMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Capillariprotective Merck 11th Edition Catabolic * Chemopreventive * Cytoprotective IC50=3 uM * Estrogenic? Economic & Medicinal Plant Research, 6: 189. Hemostat * Hepatomagenic 20,000 ppm (diet) rat Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Hepatoprotective 20 mg/kg rat * Hypocholesterolemic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Hypotensive Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Immunomodulator * Insecticide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insectiphile Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Larvistat IC95=4,000-8,000 ppm diet Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Lipoxygenase-Inhibitor IC75=2.5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Mutagenic Economic & Medicinal Plant Research, 6: 189. Myoprotective * Myorelaxant Economic & Medicinal Plant Research, 6: 189. Oviposition-Stimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. PAF-Inhibitor * Pesticide * Protisticide * Radioprotective * Sunscreen * Topoisomerase-II-Inhibitor IC50=1 ug/ml Bernard, F. X., Sable, S., Cameron, B., Provost, J., Desnottes, J. F., Crouzet, J., Blanche, F. 1997. Glycosylated Flavones as Selective Inhibitors of Topoisomerase IV. Antimicrobial Agents & Chemotherapy, 41: 992-998. Vasodilator * Vasopressor *
0	SECOLOGANIN	Leaf	--	--	--	Bate-Smith, E. C., Ferguson, I. K., Hutson, K., Jensen, S. R., Nielsen, B. J., Swain, T. 1975. Phytochemical Interrelationships in the Cornaceae. Biochem. Syst. Ecol., 3: 79.
8	STEARIC-ACID	Seed Oil	--	--	--	Hohn, M. E., Meinschein, W. G. 1976. Seed Oil Fatty Acids: Evolutionary Significance in the Nyssaceae and Cornaceae. Biochem. Syst. Ecol., 4: 193-199.
5-Alpha-Reductase-Inhibitor * Cosmetic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. FLavor FEMA 2-4,000 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.) Lubricant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Propecic * Suppository Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Cornus mas (Cornaceae)

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