Hamamelis virginiana | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Witch Hazel

How used

Medicinal

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Activities: 278

Chemicals w/Activities: 23

All Chemicals: 40

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	6-METHYLHEPTADIEN-3,5-ON(2)	Leaf	--	25.0	--	*
6	ACETALDEHYDE	Leaf	--	160.0	--	*
Addictive 8 ug/kg Science News, 145: 294. Fungicide * Perfumery FEMA 4-25 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Respiraparalytic * Tyrosinase-Inhibitor ID50=43 ug/ml *
1	AFZELIN	Leaf	--	--	--	*
ACE-Inhibitor IC50=2.8 mM *
0	ALCOHOLS	Leaf	--	2000.0	1.41	*
5	ALPHA-IONONE	Leaf	--	175.0	--	*
Allergenic * P450-1A-Inducer * P450-2B-Inducer * Perfume Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Tremorigenic Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253.
7	ASTRAGALIN	Leaf	--	--	--	*
ACE-Inhibitor ID50=180 ug/ml rat (24 hr.) * Aldose-Reductase-Inhibitor IC30=1 uM * Aldose-Reductase-Inhibitor IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antileukemic * Expectorant * Hypotensive Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Immunostimulant *
13	BETA-IONONE	Leaf	--	50.0	0.82	*
Allergenic * Antibacterial MIC=200 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Anticariogenic MIC=100 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Antimelanomic IC50=140 uM/l * Antitumor Yu, S.G., Anderson, P.J., and Elson, C.E. 1995. Efficacy of B-Ionone in the Chemoprevention of Rat Mammary Carcinogenesis. J. Agric. Food Chem. 43: 2144-2147. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cytochrome-P450-Inducer * Fungicide * Hypocholesterolemic Yu, S.G., Anderson, P.J., and Elson, C.E. 1995. Efficacy of B-Ionone in the Chemoprevention of Rat Mammary Carcinogenesis. J. Agric. Food Chem. 43: 2144-2147. Nematicide MLC=1 mg/ml Shoyakugaku Zasshi, 44: 183. P450-Inducer * Pesticide * Trichomonicide LD100=100 ug/ml *
0	CATECHIN-3-GALLATE	Bark	--	--	--	*
0	CATECHIN-TANNIN	Leaf	--	--	--	*
20	CHOLINE	Leaf	--	2000.0	-0.37	*
Antialzheimeran 5-16 g/man/day * Antichoreic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anticirrhotic 6,000 mg/man/day * Anticystinuric * Antidementia * Antidiabetic * Antidyskinetic 150-200 mg/kg/man/day Martindale's 28th Antihomocysteine * Antimanic 15-30 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antinociceptive * Antisteatotic * Cardiodepressant * Cerebrotonic * Cholinergic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Hepatoprotective * Hypotensive * Ileorelaxant * Lipotropic * Memorigenic * Parasympathomimetic (1/1,000th acetylcholine) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
0	D-GALLOCATCHEIN	Bark	--	--	--	*
8	ELLAGITANNIN	Bark	--	--	--	*
Antiallergic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. AntiHIV * Antioxidant * Antitumor * Cardiotoxic * Immunostimulant Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Interferonogenic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Reverse-Transcriptase-Inhibitor *
0	EO	Leaf	--	5000.0	-0.57	*
0	ESTERS	Leaf	--	750.0	1.03	*
62	GALLIC-ACID	Leaf	--	54400.0	1.07	*
ACE-Inhibitor IC50=7.7 mM/l * Analgesic * Antiadenovirus Economic & Medicinal Plant Research, 5: 194. Antiallergenic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Antianaphylactic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiangiogenic * Antiasthmatic Watt, J.M., and Breyer-Brandwijk, M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 1962. Antibacterial MIC=1,000 ug/ml * Antibronchitic Dorsch, W., Wagner, H. New Antiasthmatic Drugs from Traditional Medicine? Int Arch Allergy Appl Immunol 94: 262-265, 1991. Anticancer * Anticarcinomic ED50=3 * Antiescherichic * Antifibrinolytic Economic & Medicinal Plant Research, 1: 53. Antiflu Economic & Medicinal Plant Research, 5: 194. Antihepatotoxic Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Antiherpetic EC50=>10 ug/ml * AntiHIV * Antiinflammatory Kroes, B.H., et al. 1991. Anti-Inflammatory Activity of Gallic Acid. Planta Medica, 58(6): 499. Antileishmanic EC50=4.4 ug/ml * AntiMRSA * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antinitrosaminic * Antioxidant 7 x quercetin * Antioxidant 2/3 BHA * Antioxidant IC44=33 ppm * Antiperiodontitic 10 ug/ml * Antiperoxidant IC50=69 uM * Antipolio Economic & Medicinal Plant Research, 5: 194. Antiproteolytic 10 ug/ml * Antiradicular IC50=4.9 uM * Antiradicular 7 x quercetin * Antiseptic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic MIC=1,000 ug/ml * Antitumor * Antitumor-Promoter * Antiviral * Apoptotic * Astringent Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Bacteristat Lamikanra, A., Ogundaini, A.O., and Ogungbamila, F.O. Antibacterial Constituents of Alchornea cordifolia Leaves. Phytotherapy Research 4(5): 198. Bronchodilator Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Carcinogenic * Choleretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cyclooxygenase-Inhibitor * Cytotoxic 500 uM * Floral-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Gram(+)icide MIC=1,000 ug/ml * Gram(-)icide MIC=1,000 ug/ml * Hemostat * Hepatoprotective Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Immunomodulator * Immunostimulant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Immunosuppressant * Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Nephrotoxic Martindale's 29th NO-Inhibitor IC-26=250 uM * Pesticide * Styptic * Topoisomerase-I-Inhibitor Hamada, S. I., Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. 1997. Immunosuppressive Effects by Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity. Biol Pharm Bull, 20: 1017-1019. Xanthine-Oxidase-Inhibitor IC50=24 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
2	GALLO-TANNIN	Leaf	--	--	--	*
Cardiotoxic * Reverse-Transcriptase-Inhibitor *
0	HAMAMELIDINE	Leaf	--	--	--	*
0	HAMAMELIN	Leaf	--	70000.0	--	*
0	HAMAMELIN	Bark	--	160000.0	--	*
2	HAMAMELITANNIN	Bark	10000.0	30000.0	--	*
Antioxidant Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Topoisomerase-II-Inhibitor IC100=100 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Hamamelis virginiana (Hamamelidaceae)

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