Chemical CAFFEINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

CAFFEINE

CAS Registry Number

58082

Ubiquitous

List of known dosages
Dosage	Reference
LD50=127-1,200 (orl mus)	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition
LD50=192 (orl rat)
LD50=200 (orl rat)
LD50=224-246 (orl rbt)
LD50=247-355 (orl rat)	Merck 11th Edition
LDlo=192 (orl hmn)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
(+)-Inotropic	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
Adenosine-Antagonist	not available	McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82.
Analeptic	200 scu mus	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Analgesic-Synergist	not available	Duke, 1992 *
Antiapneic	not available	Martindale's 29th
Antiapoptotic	not available	Duke, 1992 *
Antiasthmatic	5-10 mg/kg orl/man	Martindale's 29th
Anticarcinogenic	not available	Duke, 1992 *
Anticariogenic	not available	Duke, 1992 *
Antidermatitic	not available	Martindale's 29th
Antiemetic	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antifeedant	not available	Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Antiflu	not available	Economic & Medicinal Plant Research, 5: 198.
Antiherpetic	not available	Duke, 1992 *
Antihypotensive	250 mg/day/orl/man	Martindale's 29th
Antinarcotic	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antiobesity	not available	Duke, 1992 *
Antioxidant	not available	Duke, 1992 *
Antirhinitic	140 mg/day/orl/man	Martindale's 29th
Antiserotonergic	40 scu rat	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Guazuma ulmifolia	Leaf	not available	not available	not available	Duke, 1992 *
Ilex paraguariensis	Leaf	2000.0	20000.0	-0.4	Duke, 1992 *
Paullinia cupana	Plant	not available	25000.0	not available	Duke, 1992 *
Paullinia cupana	Seed	9100.0	76000.0	2.2	Duke, 1992 *
Paullinia yoko	Bark	not available	27300.0	not available	Duke, 1992 *
Paullinia yoko	Leaf	not available	not available	not available	Duke, 1992 *
Theobroma angustifolium	Petiole	80.0	82.0	-1.1	Duke, 1992 *
Theobroma angustifolium	Seed	35.0	57.0	-1.0	Duke, 1992 *
Theobroma angustifolium	Testa	38.0	52.0	-1.0	Duke, 1992 *
Theobroma bicolor	Petiole	72.0	138.0	-0.3	Duke, 1992 *
Theobroma bicolor	Seed	110.0	147.0	-1.0	Duke, 1992 *
Theobroma bicolor	Testa	192.0	235.0	-0.4	Duke, 1992 *
Theobroma bicolor	Fruit	158.0	184.0	not available	Duke, 1992 *
Theobroma cacao	Petiole	51.0	252.0	1.3	Duke, 1992 *
Theobroma cacao	Seed	500.0	12900.0	-0.5	Duke, 1992 *
Theobroma cacao	Testa	130.0	723.0	1.4	Duke, 1992 *
Turnera diffusa	Shoot	not available	not available	not available	Duke, 1992 *
Turnera diffusa	Leaf	not available	not available	not available	Duke, 1992 *