Chemical BERBERINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

BERBERINE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Lachrymatory	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Larvicide	9 ppm	Duke, 1992 *
Leucocytogenic	not available	Duke, 1992 *
Lipase-Inhibitor	not available	Medline (post 1990 searches filed in my computer)
Lipoxygenase-Inhibitor	IC50=118 uM	Duke, 1992 *
Mutagenic	not available	Duke, 1992 *
Mycobactericide	MIC=25-50 ug/ml	Duke, 1992 *
Mydriatic	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Myocardiodepressant	not available	Duke, 1992 *
Myorelaxant	not available	Duke, 1992 *
Pesticide	not available	Duke, 1992 *
Phototoxic	9 ppm	Duke, 1992 *
Plasmodicide	IC50=0.14-0.36 ug/ml	Duke, 1992 *
Prostaglandin-Synthesis-Inhibitor	25 mg/kg ivn rbt	Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
Protisticide	IC50=0.14-0.36 ug/ml	Duke, 1992 *
Respiradepressant	not available	Martindale's 28th
RNA-Depressant	not available	Duke, 1992 *
RT-Inhibitor	not available	Duke, 1992 *
Sedative	not available	Duke, 1992 *
Stomachic	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Hydrastis canadensis	Rhizome	not available	50000.0	-1.5	Duke, 1992 *
Hydrastis canadensis	Shoot	not available	not available	not available	Duke, 1992 *
Macleaya cordata	Plant	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Root Bark	not available	not available	not available	Kukic, P., Nikolic, R., Gorunovic, M. 1972. Comparative Pharmacognostic Study of Berberis (Barberry) vulgaris and Berberis aquifolium. Acta Pharm Jugosl, 22: 19-24.
Mahonia aquifolium	Leaf	not available	13.0	-1.0	Slavik, J., Bochorakova, J., Kostalova, D., Hrochova, V. 1985. Alkaloids of Mahonia aquifolium (Pursh) Nutt. II. Chem Pap, 39(4): 537-542.
Mahonia aquifolium	Wood	not available	not available	not available	Slavik, J., Bochorakova, J., Kostalova, D., Hrochova, V. 1985. Alkaloids of Mahonia aquifolium (Pursh) Nutt. II. Chem Pap, 39(4): 537-542.
Mahonia aquifolium	Root	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Plant	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Bark	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Shoot	not available	not available	not available	Duke, 1992 *
Mahonia fargesii	Root	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fargesii	Stem	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fargesii	Bark	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fortunei	Leaf	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia gracilipes	Root	not available	not available	not available	Lu, G. H., Chen, J. M., Wang, L. W., Xiao, P. G. 1995. Chemical Constituents of Mahonia gracilipes (Oliv.) Fedde. Huaxi Yaoxue Zazhi, 10(4): 202-204.
Mahonia japonica	Stem	not available	not available	not available	Battersby, A. R., Francis, R. J., Hirst, M., Ruveda, E. A., Staunton, J. 1975. Biosynthesis. Part XXI. Investigations on the Biosynthesis of Stylopine in Chelidonium Majus. J Chem Soc Perkin Trans I: 1140.
Mahonia japonica	Sprout Seedling	not available	not available	not available	Ikuta, A. and Itokawa, H. 1982. Studies on the Alkaloids from Tissue Culture of Nandina domestica. Plant Tissue Cult Proc Int Congr Plant Tissue Cell Cult 5th: 315316.
Mahonia nervosa	Rhizome	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia philipinensis	Root	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia repens	Root	not available	1417.0	-1.2	Duke, 1992 *