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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Prostaglandin-Synthesis-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-TETRANDRINE 10 uM Pang, L. H., Hoult, J. R. S. 1997. Cytotoxicity to Macrophages of Tetrandrine, an Antisilicosis Alkaloid, Accompanied by an Overproduction of Prostaglandins. Biochem Pharmacol, 53(6): 773-782.
(-)-MELLEIN IC50=340 uM Pongprayoon, U. 1991. Pharmacognostic Studies on the Thai Medicinal Plant Ipomoea pes-caprae (L.) R.BR. (Pak Bung Ta Lae). Acta Pharm Nordica, 3(3). 186 pp.
(1S-2-TRANS-4R-6R-7-TRANS)-CEMBRA-2,7,12-(20-TRIENE-4,6,11-TRIOL) IC50=13 mM Olsson, E., Holth, A., Kumlin, E., Bohlin, L., Wahlberg, I. 1993. Structure-Related Inhibiting Activity of some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro. Planta Medica, 59(4): 293-295.
(1S-2-TRANS-4R-6R-7-TRANS-11-TRANS)-CEMBRA-2,7,11-TRIENE-4,6-DIOL IC50=0.39 mM Olsson, E., Holth, A., Kumlin, E., Bohlin, L., Wahlberg, I. 1993. Structure-Related Inhibiting Activity of some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro. Planta Medica, 59(4): 293-295.
(1S-2-TRANS-4S-6R-7-TRANS)-CEMBRA-2,7,12-(20-TRIENE-4,6,11-TRIOL) IC50=2.7 mM Olsson, E., Holth, A., Kumlin, E., Bohlin, L., Wahlberg, I. 1993. Structure-Related Inhibiting Activity of some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro. Planta Medica, 59(4): 293-295.
(1S-2-TRANS-4S-6R-7-TRANS-11-TRANS)-CEMBRA-2,7,11-TRIENE-4,6-DIOL IC50=0.36 mM Olsson, E., Holth, A., Kumlin, E., Bohlin, L., Wahlberg, I. 1993. Structure-Related Inhibiting Activity of some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro. Planta Medica, 59(4): 293-295.
(2S)-5-METHOXY-6-METHYLFLAVAN-7-OL 50 uM Tsai, W.J., Hsieh, H.T., Chen, C.C., Kuo, Y.C., Chen, C.F. 1998. Characterization of the Antiplatelet Effects of (2S)-5-methoxy-6-methylflavan-7-ol from Draconis resina.
1,2,4-TRIHYDROXY-BENZENE IC50=900 uM Alanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
1,3,5-TRIHYDROXY-BENZENE IC50=45 uM Alanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
2-HYDROXY-4,4,7-TRIMETHYL-(4H)-NAPHTHALEN-1-ONE IC50=230 uM Pongprayoon, U. 1991. Pharmacognostic Studies on the Thai Medicinal Plant Ipomoea pes-caprae (L.) R.BR. (Pak Bung Ta Lae). Acta Pharm Nordica, 3(3). 186 pp.
3,3',7-TRIMETHYL-ETHER-6-C-METHYLQUERCETIN IC50=4.5 uM Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3,7-DIMETHYL-ETHER-6,8-DI-C-METHYLKAEMPFEROL 20 ug/ml Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3,7-DIMETHYL-ETHER-6,8-DI-C-METHYLQUERCETIN 20 ug/ml Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3,7-DIMETHYL-ETHER-6-C-METHYLQUERCETIN IC50=25.9 uM Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3-METHYL-ETHER-6,8-DI-C-METHYLKAEMPFEROL 40 ug/ml Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3-METHYL-ETHER-6,8-DI-C-METHYLQUERCETIN IC50=23 uM Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3-METHYL-ETHER-6-C-METHYLQUERCETIN IC50=55.4 uM Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
3-METHYLQUERCETIN 50 ug/ml rbt Lackeman, G. M., Claeys, M., Rwangabo, P. C., Herman, A. G., Vlietinck, A. J. 1986. Cardiovascular Effects of 3-methylquercetin. Planta Medica, 52(6): 433-437.
4-VINYL-GUAIACOL IC50=18 uM *
6-(3-CARBOXY-BUT-2-ENYL)-7-HYDROXYCOUMARIN 1.3 ug/ml rbt Hiermann, A., Schantl, D. 1998. Antiphlogistic and Antipyretic Activity of Peucedanum ostruthium. Planta Medica, 64(5): 400-403.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 2 70
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 1 0
Abies balsamea Balsam Fir 1 0
Abrus precatorius Crab's Eye; Jequerity; Coral Beadplant; Indian Licorice; Licorice Vine; Love Bean; Lucky Bean; Minnie-Minnies; Prayer Beads; Precatory Bean; Red Beadvine; Rosary Pea; Weatherplant; Weathervine; Jequirity Bean 1 1, 687, 500
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 1 0
Acacia catechu Black Cutch; Catechu 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 1 0
Acacia lenticularis 1 46.599998474121094
Acacia modesta 1 0
Acacia nilotica Babul 3 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 2 0
Acacia tortilis Umbrella Thorn 1 0
Acanthus ilicifolius 1 0
Achillea millefolium Yarrow; Milfoil 3 0
Achyranthes aspera Chaff Flower 1 0
Achyranthes bidentata Chaff Flower 1 0
Acinos suaveolens 1 430
Acinos thymoides 1 500
Acorus calamus Sweetflag; Calamus; Flagroot; Myrtle Flag; Sweet Calamus; Sweetroot 1 3, 600
Acrotrema arnottianum 2 11, 250