Chemical BERBERINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

BERBERINE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Cardiodepressant	not available	Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Cardiotonic	not available	Duke, 1992 *
Carminative	not available	Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Cholagogue	not available	Duke, 1992 *
Cholekinetic	not available	Duke, 1992 *
Choleretic	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Collyrium	not available	Duke, 1992 *
COX-2-Inhibitor	100 ug/ml	Duke, 1992 *
Cyclooxygenase-Inhibitor	not available	Duke, 1992 *
Cytotoxic	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Digestive	not available	Duke, 1992 *
Diuretic	not available	Duke, 1992 *
Emetic	not available	Duke, 1992 *
Fungicide	12.5-150 ug/ml	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Glaucomagenic	not available	Duke, 1992 *
Hemostat	not available	Duke, 1992 *
Hypocholesterolemic	not available	Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.
Hypoglycemic	not available	Duke, 1992 *
Hypotensive	not available	Duke, 1992 *
Immunostimulant	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Hydrastis canadensis	Rhizome	not available	50000.0	-1.5	Duke, 1992 *
Hydrastis canadensis	Shoot	not available	not available	not available	Duke, 1992 *
Macleaya cordata	Plant	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Leaf	not available	13.0	-1.0	Slavik, J., Bochorakova, J., Kostalova, D., Hrochova, V. 1985. Alkaloids of Mahonia aquifolium (Pursh) Nutt. II. Chem Pap, 39(4): 537-542.
Mahonia aquifolium	Wood	not available	not available	not available	Slavik, J., Bochorakova, J., Kostalova, D., Hrochova, V. 1985. Alkaloids of Mahonia aquifolium (Pursh) Nutt. II. Chem Pap, 39(4): 537-542.
Mahonia aquifolium	Root	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Plant	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Bark	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Shoot	not available	not available	not available	Duke, 1992 *
Mahonia aquifolium	Root Bark	not available	not available	not available	Kukic, P., Nikolic, R., Gorunovic, M. 1972. Comparative Pharmacognostic Study of Berberis (Barberry) vulgaris and Berberis aquifolium. Acta Pharm Jugosl, 22: 19-24.
Mahonia fargesii	Root	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fargesii	Stem	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fargesii	Bark	not available	not available	not available	Liu, M. I., Feng, H. L. 1991. The Alkaloids Content of the Different Parts in Dayecihuangbai (Mahonia fargesii) by HPLC. Chung Ts'ao Yao, 22(7): 308-309.
Mahonia fortunei	Leaf	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia gracilipes	Root	not available	not available	not available	Lu, G. H., Chen, J. M., Wang, L. W., Xiao, P. G. 1995. Chemical Constituents of Mahonia gracilipes (Oliv.) Fedde. Huaxi Yaoxue Zazhi, 10(4): 202-204.
Mahonia japonica	Stem	not available	not available	not available	Battersby, A. R., Francis, R. J., Hirst, M., Ruveda, E. A., Staunton, J. 1975. Biosynthesis. Part XXI. Investigations on the Biosynthesis of Stylopine in Chelidonium Majus. J Chem Soc Perkin Trans I: 1140.
Mahonia japonica	Sprout Seedling	not available	not available	not available	Ikuta, A. and Itokawa, H. 1982. Studies on the Alkaloids from Tissue Culture of Nandina domestica. Plant Tissue Cult Proc Int Congr Plant Tissue Cell Cult 5th: 315316.
Mahonia nervosa	Rhizome	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia philipinensis	Root	not available	not available	not available	Willaman, J. J., Li, H. L. 1970. Alkaloid-Bearing Plants and their Contained Alkaloids, 1957-1968. Lloydia, 33: 1-286.
Mahonia repens	Root	not available	1417.0	-1.2	Duke, 1992 *