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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-II-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-DICENTRINE IC50=27 uM Woo, S. H., Sun, N. J., Cassady, J. M., Snapka, R. M. 1999. Topoisomerase II Inhibition by Aporphine Alkaloids. Biochem Pharmacol, 57: 1141-1145.
1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1,3,4,5-TETRA-O-GALLOYL-QUINIC-ACID IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1-2-3-6-TETRA-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1-BETA-GALLOYL-PEDUNCULAGIN IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
10-HYDROXYLIRIODENINE IC50=12.5 ug/ml Harrigan, G. G., Gunatilaka, A. A. L., Kingston, D. G. I., Chan, G. W., Johnson, R. K. 1994. Isolation of Bioactive and Other Oxoaporphine Alkaloids From Two Annonaceous Plants, Xylopia aethiopica and X. muliusa cf. banacea. J Natural Products, 57: 68-73.
10-METHOXYLIRIODENINE IC50=25 ug/ml Harrigan, G. G., Gunatilaka, A. A. L., Kingston, D. G. I., Chan, G. W., Johnson, R. K. 1994. Isolation of Bioactive and Other Oxoaporphine Alkaloids From Two Annonaceous Plants, Xylopia aethiopica and X. muliusa cf. banacea. J Natural Products, 57: 68-73.
14-CHLORO-15-HYDROXYXESTOQUINONE IC90=135 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
14-METHOXYXESTOQUINONE IC90=143 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
15-CHLORO-14-HYDROXYXESTOQUINONE IC90=135 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
15-METHOXYXESTOQUINONE IC90=143 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
2',3,5-TRI-O-GALLOYL-HAMAMELOSE IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
2,3-HEXAHYDROXYDIPHENOYL-D-GLUCOSE IC100=100 mM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3',4'-DIDEMETHYL-EPIPODOPHYLLOTOXIN 0.4 mM *
3,4,5-TRI-O-GALLOYL-QUINIC-ACID IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3,5-DI-O-GALLOYLSHIKIMIC-ACID IC100=5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3-O-GALLOYLSHIKIMIC-ACID IC100=5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
4'-DEMETHYL-EPIPODOPHYLLOTOXIN 100 uM Lee, K. H., et al. 1989. Antitumor Agents. 107. New Cytotoxic 4-alkylamino Analogues of 4'-demethyl-epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II. J Natural Products, 52: 606-613.
4'-DEMETHYLPODOPHYLLOTOXIN 100 uM Lee, K. H., et al. 1989. Antitumor Agents. 107. New Cytotoxic 4-alkylamino Analogues of 4'-demethyl-epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II. J Natural Products, 52: 606-613.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Betula ermanii 1 0
Betula lenta Cherry Birch 1 500
Betula maximowicziana 1 32, 000
Betula papyrifera 1 15, 000
Betula platyphylla 1 0
Betula populifolia 1 0
Betula sp. 1 0
Betula utilis 1 0
Bidens pilosa 1 12
Boehmeria nivea Ramie 1 0
Borago officinalis Borage; Beebread; Beeplant; Talewort 2 0
Bowdichia nitida 1 0
Brassica nigra Black Mustard 1 0
Brassica oleracea Kohlrabi 2 120
Brassica oleracea var. botrytis l. Cauliflower 3 42
Brassica oleracea var. capitata l. Cabbage; Red Cabbage; White Cabbage 2 1, 500
Brassica oleracea var. gemmifera Brussels-Sprouts; Brussel-Sprout 2 140
Brassica oleracea var. italica Broccoli; Heading Broccoli; Sprouting Broccoli; Cape Broccoli; Purple Cauliflower; Asparagus Broccoli; Winter Broccoli; Calabrese 3 0
Brassica oleracea var. sabellica l. Kale; Curly Kale; Kitchen Kale; Scotch Kale 2 452
Bruguiera gymnorrhiza 1 0