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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-I-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
10-HYDROXYCAMPTOTHECIN 0.4-1 uM *
17-BETA-ESTRADIOL Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
20(S)-CAMPTOTHECIN IC50=0.52 uM Wall, M.E., Wani, M.C., Nicholas, A.W., Manikumar, G., Tele, C., Moore, L., Truesdale, A., Leitner, P., Besterman, J.M. 1993. Plant Antitumor Agents. 30. Synthesis and Structure Activity of Novel Camptothecin Analogs. J Med Chem, 36: 2689-2700.
3',5',7-TRI-O-METHYLTRICETIN 1 ug/mL Zahir, A., Jossang, A., Bodo, B., Provost, J., Cosson, J. P., Sevenet, T. 1996. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones From Lethedon tannaensis. J Natural Products, 59: 701-703.
4-NEROLIDYL-CATECHOL IC50=20 ug/ml Monqelli, E., Aromano, a., Desmarchelier, C., Coussio, J., Ciccia, G. 1999. Cytotoxic 4-nerolidylcatechol From Pothomorphe peltata Inhibits Topoisomerase I Activity. Planta Medica, 65: 376-378.
5,6-DIHYDRO-8-DEMETHYLCORYALYNE 0.26 uM Pilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
7-HYDROXY-FLAVONE 100 ug/ml *
8-DEMETHYLCORALYNE 26 uM Pilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
ACACETIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
ALNUMYCIM Bieber, B., Nueske, J. 1998. Alnumycin, a New Metabolite From Streptomyces sp., Procedure For Its Production And Its Biological Effect. Patent, Ger Offen-19,745,914. 10pp.
ALPHA-BOSWELLIC-ACID-ACETATE IC>80=5 uM *
AMAROGENTIN 5 uM Ray, S., Majumder, H.K., Chakravarty, A.K., Mukhopadhyay, S., Gil, R.R., Cordell, G.A.1996.Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I From Leishmania donovani. J Natural Products, 59: 27-29
AMPHIMIC-ACID-A Nemoto, T., Ojika, M., Sakagami, Y. 1997. Amphimic Acids, Novel Unsaturated C28 Fatty Acids as DNA Topoisomerase I Inhibitors From an Australian Sponge Amphimedon sp. Tetrahedron Letters, 38: 5667-5670.
APIGENIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
APIODIONEN 83 ug/ml Takahashi, H., Shiraishi, A., Iizuka, Y., Furuya, K., Kagasaki, T. 1992. Manufacture of Anticancer and Anti-Inflammatory Apiodionen With Apiosordaria. Patent, Japan Kokai Tokkyo Koho-04 49,289. 8pp.
BETA-LAPACHONE 250 uM Li, C. J., Verboukh, L., Pardee, A. B. 1993. Beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecin. J Biol Chem, 268: 22463-22468.
BETA-LAPACHONE 1 ug/mL Frydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
BETA-LAPACHONE IC50=1 uM Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
BIOCHANIN-A Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
BIS-DEMETHOXYCURCUMIN 25 ug/ml *
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Eucommia ulmoides Tu Chung; Du Zhong; Gutta-Percha Tree 1 0
Eupatorium perfoliatum Boneset 3 0
Euphorbia hirta Queensland Asthma Herb 3 0
Euphorbia lathyris Caper Spurge; Mole Plant 2 0
Euphrasia officinalis Eyebright 5 0
Fagopyrum esculentum Buckwheat 1 50
Ferula assa-foetida Asafetida; Asafoetida; Assa-foetida; Devil's Dung; Stinkasant (Ger.); Asafetida (Sp.); test 1 0
Ficus carica Fig; Figuier Commun (Fr.); Echte Feige (Ger.); Feigenbaum (Ger.); Fico (Ital.); Figueira (Port.); Higo (Sp.); Higuera Comun (Sp.) 2 0
Filipendula ulmaria Meadowsweet; Queen Of The Meadow 2 0
Firmiana simplex Chinese Parasol 1 0
Flemingia strobilifera 1 36
Foeniculum vulgare Fennel 2 0
Forsythia suspensa Lian-Jiao; Lien-Chiao 1 0
Fragaria spp Strawberry 4 121
Frangula alnus Buckthorn 1 0
Galactia jussiaeana 1 0
Galega officinalis Goat's Rue; Galega 2 0
Gaultheria procumbens Teaberry; Wintergreen; Checkerberry; Creeping Wintergreen; Mountain Tea; Wintergrun (Ger.) 1 0
Genipa americana Genipap; Jagua 1 90, 000
Genista clavata 1 0