Chemical BETA-LAPACHONE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Dr. Duke's Phytochemical and Ethnobotanical Databases

U.S. Department of Agriculture

Chemical ID

BETALAPACHONE

Ubiquitous

No

Download these results as:

List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Antitrypanosomic	not available	Duke, 1992 *
Reverse-Transcriptase-Inhibitor	not available	Duke, 1992 *
Topoisomerase-I-Inhibitor	250 uM	Li, C. J., Verboukh, L., Pardee, A. B. 1993. Beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecin. J Biol Chem, 268: 22463-22468.
Topoisomerase-I-Inhibitor	1 ug/mL	Frydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
Topoisomerase-I-Inhibitor	IC50=1 uM	Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.

Download these results as:

List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Tabebuia impetiginosa	Bark	not available	not available	not available	Duke, 1992 *
Tabebuia impetiginosa	Heart Wood	not available	152.0	not available	Duke, 1992 *
Tabebuia impetiginosa	Wood	not available	not available	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.