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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-I-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
10-HYDROXYCAMPTOTHECIN 0.4-1 uM *
17-BETA-ESTRADIOL Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
20(S)-CAMPTOTHECIN IC50=0.52 uM Wall, M.E., Wani, M.C., Nicholas, A.W., Manikumar, G., Tele, C., Moore, L., Truesdale, A., Leitner, P., Besterman, J.M. 1993. Plant Antitumor Agents. 30. Synthesis and Structure Activity of Novel Camptothecin Analogs. J Med Chem, 36: 2689-2700.
3',5',7-TRI-O-METHYLTRICETIN 1 ug/mL Zahir, A., Jossang, A., Bodo, B., Provost, J., Cosson, J. P., Sevenet, T. 1996. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones From Lethedon tannaensis. J Natural Products, 59: 701-703.
4-NEROLIDYL-CATECHOL IC50=20 ug/ml Monqelli, E., Aromano, a., Desmarchelier, C., Coussio, J., Ciccia, G. 1999. Cytotoxic 4-nerolidylcatechol From Pothomorphe peltata Inhibits Topoisomerase I Activity. Planta Medica, 65: 376-378.
5,6-DIHYDRO-8-DEMETHYLCORYALYNE 0.26 uM Pilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
7-HYDROXY-FLAVONE 100 ug/ml *
8-DEMETHYLCORALYNE 26 uM Pilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
ACACETIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
ALNUMYCIM Bieber, B., Nueske, J. 1998. Alnumycin, a New Metabolite From Streptomyces sp., Procedure For Its Production And Its Biological Effect. Patent, Ger Offen-19,745,914. 10pp.
ALPHA-BOSWELLIC-ACID-ACETATE IC>80=5 uM *
AMAROGENTIN 5 uM Ray, S., Majumder, H.K., Chakravarty, A.K., Mukhopadhyay, S., Gil, R.R., Cordell, G.A.1996.Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I From Leishmania donovani. J Natural Products, 59: 27-29
AMPHIMIC-ACID-A Nemoto, T., Ojika, M., Sakagami, Y. 1997. Amphimic Acids, Novel Unsaturated C28 Fatty Acids as DNA Topoisomerase I Inhibitors From an Australian Sponge Amphimedon sp. Tetrahedron Letters, 38: 5667-5670.
APIGENIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
APIODIONEN 83 ug/ml Takahashi, H., Shiraishi, A., Iizuka, Y., Furuya, K., Kagasaki, T. 1992. Manufacture of Anticancer and Anti-Inflammatory Apiodionen With Apiosordaria. Patent, Japan Kokai Tokkyo Koho-04 49,289. 8pp.
BETA-LAPACHONE 250 uM Li, C. J., Verboukh, L., Pardee, A. B. 1993. Beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecin. J Biol Chem, 268: 22463-22468.
BETA-LAPACHONE 1 ug/mL Frydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
BETA-LAPACHONE IC50=1 uM Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
BIOCHANIN-A Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
BIS-DEMETHOXYCURCUMIN 25 ug/ml *
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Cornus florida American Dogwood 3 0
Cornus mas Cornelian Cherry; Sorbet 3 0
Cornus officinalis Chinese Dogwood 1 0
Corylus americana American Filbert; American Hazel 1 0
Corylus avellana English Filbert; European Filbert; European Hazel; Hazel; Cobnut 3 0
Costus speciosus Crepe Ginger; Wild Ginger; Cane Reed 1 0
Crataegus cuneata Hawthorn 1 0
Crataegus laevigata Hawthorn; English Hawthorn; Whitethorn; Woodland Hawthorn 3 0
Crataegus monogyna Hawthorn; English Hawthorn 4 80
Crataegus rhipidophylla Hawthorn 3 0
Crocus sativus Saffron 3 0
Crotalaria juncea Sunhemp 1 0
Cucurbita pepo Pumpkin 2 0
Cuminum cyminum Cumin 1 0
Curcuma longa Turmeric; Indian Saffron 4 520, 380
Curcuma xanthorrhiza Javan Turmeric; Temu Lawak 1 20, 000
Curcuma zedoaria Shoti; Zedoary 1 2, 000
Cuscuta reflexa Amarbel 2 0
Cyamopsis tetragonoloba Guar; Cluster-Bean; Siam-Bean 3 0
Cymbopogon citratus West Indian Lemongrass; Lemongrass 2 0