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Biological Activity Prostaglandin-Synthesis-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
6-GINGEROL 1 mM (60.7% inhibition) Duke, 1992 *
8-BETA-17-EPOXY-LABD-TRANS-12-ENE-15,16-DIAL IC50=100 uM Kawakishi, S., Morimitsu, Y., Osawa, T. 1994. Chemistry of Ginger Components and Inhibitory Factors of the Arachidonic Acid Cascade. ASC Symp Ser, 547: 244-250.
AESCULETIN 100 uM rbt Hung, H.C., Lai, M.W., Wang, H.R., Chung, Y.L., Hsieh, L.M., Chen, C.C. 1993. Antiproliferative Effect of Esculetin on Vascular Smooth Muscle Cells: Possible Roles of Signal Transduction Pathways. Eur J Pharmacol, 237(1): 39-44.
ALPHA-LINOLENIC-ACID 39.5 g/day/hmn Ferretti, A., Flanagan, V. P. 1996. Antithromboxane Activity of Dietary Alpha-linolenic Acid: A Pilot Study. Prostaglandins Leukotrienes Essential Fatty Acids, 54(6): 451-455. ARS, USDA.
ALPHITOL IC50=0.66 mM Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
ARNEBINONE 20 ug/ml Yao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
AVAROL 3 ug/ml Schroder,H.C., Begin,E., Klocking,R., Matthes,E., Sarma,A.S., Gasic,M., Muller,W.E.G.1991.Avarol Restores the Altered Prostaglandin and Leukotriene Metabolism in Monocytes Infected with Human Immunodeficiency Virus Type I. Virus Research, 21(3):213-223.
BERBERASTINE 25 mg/kg ivn rbt Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
BERBERINE 25 mg/kg ivn rbt Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
BETULIN IC50=119 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
BETULINIC-ACID 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
BETULINIC-ACID IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
BOLDINE 25 uM rat Backhouse, N., Delporte, C., Givernau, M., Cassels, B. K., Valenzuela, A., Speisky, H. 1994. Anti-Inflammatory and Antipyretic Effects of Boldine. Agents & Actions, 42(3/4): 114-117.
CAFFEIC-ACID-MALATE IC50=38 ug/ml Obertreis, B., Giller, K., Teucher, T., Behnke, B., Schmitz, H. 1996. Antiphlogistic Effects of Urtica dioica folia Extract in Comparison to Caffeic Malic Acid. Arzneim-Forsch, 46(1): 52-56.
CURCUMIN 0.2% diet rat Rao, C. V., Rivenson, A., Simi, B., Reddy, B. S. 1995. Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Research, 55(2): 259-266.
DIINSINIOL IC50=9.2 uM (weak activity) Ogundaini, A., Farah, M., Perera, P., Samuelsson, G., Bohlin, L. 1996. Isolation of two new Antiinflammatory Biflavanoids from Sarcophyte piriei. J Natural Products, 59(6): 587-590.
EMODIN IC50=23 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414.
ENT-8-ALPHA-HYDROXY-LABDA-13(16),14-DIENE IC50=3 uM mus De Las Heras, B., Hoult, J. R. S. 1994. Non-Cytotoxic Inhibition of Macrophage Eicosanoid Biosynthesis and Effects on Leukocyte Functions and Reactive Oxygen Species of two Novel-Anti-Inflammatory Plant Diterpenoids. Planta Medica, 60(6): 501-506.
EUGENOL 1 mM rbt Chen, S. J., Wang, M. H., Chen, I. J. 1996. Antiplatelet and Calcium Inhibitory Properties of Eugenol and Sodium Eugenol Acetate. Gen Pharmacol, 27(4): 629-633.
EUGENOL IC50=9.2 uM Duke, 1992 *
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 2 70
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 1 0
Abies balsamea Balsam Fir 1 0
Abrus precatorius Crab's Eye; Jequerity; Coral Beadplant; Indian Licorice; Licorice Vine; Love Bean; Lucky Bean; Minnie-Minnies; Prayer Beads; Precatory Bean; Red Beadvine; Rosary Pea; Weatherplant; Weathervine; Jequirity Bean 1 1, 687, 500
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 1 0
Acacia catechu Black Cutch; Catechu 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 1 0
Acacia lenticularis not available 1 46.599998474121094
Acacia modesta not available 1 0
Acacia nilotica Babul 3 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 2 0
Acacia tortilis Umbrella Thorn 1 0
Acanthus ilicifolius not available 1 0
Achillea millefolium Yarrow; Milfoil 3 0
Achyranthes aspera Chaff Flower 1 0
Achyranthes bidentata Chaff Flower 1 0
Acinos suaveolens not available 1 430
Acinos thymoides not available 1 500
Acorus calamus Sweetflag; Calamus; Flagroot; Myrtle Flag; Sweet Calamus; Sweetroot 1 3, 600
Acrotrema arnottianum not available 2 11, 250