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Biological Activity Prostaglandin-Synthesis-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
EUGENOL-ACETATE 1 mM rbt Chen, S. J., Wang, M. H., Chen, I. J. 1996. Antiplatelet and Calcium Inhibitory Properties of Eugenol and Sodium Eugenol Acetate. Gen Pharmacol, 27(4): 629-633.
FALCARINOL not available Fujimoto, Y., et al. 1998. Inhibition of 15-hydroxyprostaglandin Dehydrogenase Activity in Rabbit Gastric Antral Mucosa by Panaxynol Isolated from Oriental Medicines. J Pharmacy & Pharmacology, 50(9): 1075-1078.
FERULIC-ACID 0.58-3.2 mM Xu, L. N., Yu, W. G., Tian, J. Y., Liu, Q. Y. 1990. Effect of Sodium Ferulate on Arachidonic Acid Metabolism. Yao Hsueh Hsueh Pao, 25(6): 412-416.
GALLIC-ACID-PROPYL-ESTER IC50=100 uM Alanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
GINSENOSIDE-RC 500 ug/ml Park, C. W. 1992. The Effects of Ginseng Components on Arachidonic Acid Metabolism. Korean J Ginseng Science, 16(1): 69-71.
GLAUCOCALYXIN-A 10 uM rbt Zhang, B., Long, K., Jiang, Y. Y. 1992. Effects of Glaucocalyxin a on PAF Biosynthesis and Arachidonic Acid Metabolism in Washed Rabbit Platelets. Zhongguo Yaolixue ye Dulixue Zazhi, 6(1): 52-55.
GLYCYRRHIZIN 100 mg/kg igs mus Ren, J., Cheng, J. X., Wang, Z. G. 1988. Effects of Ammonium Glycyrrhizinate on the Synthesis of Prostaglandins E2 and F2-alpha. K'o Hsueh T'ung Pao, (3): 227-229.
GOSSYPOL 8.4-380 nM Xiao, D. M., Wang, X. L., Zhang, J. B., Chen, H. C. 1991. Effects of Gossypol of Phorbol Ester-Calcimycin-induced Prostaglandin Synthesis by Macrophages. Chin Med J, 104(4): 321-325.
GUAIACOL IC50=57 uM Alanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
LABDA-TRANS-8(17)-12-DIENE-15-16-DIAL IC50=100 uM Kawakishi, S., Morimitsu, Y., Osawa, T. 1994. Chemistry of Ginger Components and Inhibitory Factors of the Arachidonic Acid Cascade. ASC Symp Ser, 547: 244-250.
MYRICETIN-3-O-BETA-D-GLUCURONIDE 1 ug rbt Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
NORATHYRIOL IC50=29.1 mg/kg ipr mus Wang, J. P., Ho, T. F., Lin, C. N., Tang, C. M. 1994. Effect of Norathryiol, Isolated from Tripterospermum lanceolatum, on A23 187-Induced Pleurisy and Analgesia in Mice. Naunyn-Schmiedeberg's Arch Pharmacol, 350(1): 90-95.
OLEANOLIC-ACID igs mus Duke, 1992 *
P-COUMARIC-ACID not available Duke, 1992 *
PYROGALLOL IC50=900 uM Alanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
QUERCETIN 40 ug/ml Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
SALIPURPOSIDE IC50=13.14 uM Ogundaini, A., Farah, M., Perera, P., Samuelsson, G., Bohlin, L. 1996. Isolation of two new Antiinflammatory Biflavanoids from Sarcophyte piriei. J Natural Products, 59(6): 587-590.
SHIKONOFURAN-B 20 ug/ml (72% inhibition) Yao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
SHIKONOFURAN-C 20 ug/ml (72% inhibition) Yao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
SINOMENINE IC50=1 mM Liu, L, Riese, J., Resch, K., Kaever, V. 1994. Impairment of Macrophage Eicosanoid and Nitric Oxide Production by an Alkaloid from Sinomenium acutum. Arzneim-Forsch, 44(11): 1223-1226.
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 2 70
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 1 0
Abies balsamea Balsam Fir 1 0
Abrus precatorius Crab's Eye; Jequerity; Coral Beadplant; Indian Licorice; Licorice Vine; Love Bean; Lucky Bean; Minnie-Minnies; Prayer Beads; Precatory Bean; Red Beadvine; Rosary Pea; Weatherplant; Weathervine; Jequirity Bean 1 1, 687, 500
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 1 0
Acacia catechu Black Cutch; Catechu 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 1 0
Acacia lenticularis not available 1 46.599998474121094
Acacia modesta not available 1 0
Acacia nilotica Babul 3 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 2 0
Acacia tortilis Umbrella Thorn 1 0
Acanthus ilicifolius not available 1 0
Achillea millefolium Yarrow; Milfoil 3 0
Achyranthes aspera Chaff Flower 1 0
Achyranthes bidentata Chaff Flower 1 0
Acinos suaveolens not available 1 430
Acinos thymoides not available 1 500
Acorus calamus Sweetflag; Calamus; Flagroot; Myrtle Flag; Sweet Calamus; Sweetroot 1 3, 600
Acrotrema arnottianum not available 2 11, 250