Biological Activity MDR-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)

Chemical Name Sort descending	Dosage	Reference
ARTEMISININ	IC50=2 uM	Duke, 1992 *
BRAZILIN	50 mg/kg ipr mus	Choi, S. Y., Yang, K. M., Jeon, S. D., Kim, J. H., Khil, L. Y., Chang, T. S., Moon, C. K. 1997. Brazilin Modulates Immune Function Mainly by Augmenting T-Cell Activity in Halothane Administered Mice. Planta Medica, 63: 405-408.
BREVIFOLIOL	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
CELAFOLIN-A1	IC50=0.77 uM	Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELAFOLIN-A1	IC50=1.45 uM	Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELORBICOL-ESTER	IC50=1.36 uM	Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CHALCONE	100 uM	Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
CINCHONINE	250 mg/kg igs rat	Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
CINCHONINE	5 uM	Duke, 1992 *
COLCHICEINE	ED50=15 ng/ml	Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICIDE	ED50=410 ng/ml	Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
CONODURAMINE	IC50=0.6 ug/ml	You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CONOPHYLLINE-QUINONE	not available	Takahashi, K., Koyano, T., Komiyama, H., Kam, T. S. 1998. Conophylline Quinone as a New Antitumor Agent. Patent, Japan Kokai Tokkyo Koho-10 45,763. 5pp.
CORONARIDINE	IC50=1.9 ug/ml	You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CURCUMIN	1-55 uM	Duke, 1992 *
DEACETYL-COLCHICEINE	ED50=27 ng/ml	Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DECINNAMOYL-TAXAGIFINE	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DEMECOLCINE	ED50=78 ng/ml	Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DENDROAMIDE-A	5 uM	Ogino, J., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1996. Dendroamides, New Cyclic Hexapeptides From a Blue-Green Alga. Multidrug-Resistance Reversing Activity of Dendroamide A. J. Nat. Prod., 59(6): 581-586.
DIACETYLTAXININE-B	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.