Biological Activity MDR-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)

Chemical Name Sort descending	Dosage	Reference
(+)-CEPHARANTHINE	IC50=2.06 uM	Duke, 1992 *
(+)-CEPHARANTHINE	1 ug/mL	Hotta,T., Tanimura,H., Yamaue,H., Iwahashi,M., Tani,M., Tsunoda,T., Tamami,M., Moguchi,K., Mizobata,S., Arii,K., Teraswa,H. 1997. Modulation of Multidrug Resistance by Cepharanthine in Fresh Human Gastrointestinal Tumor Cells. Oncology, 54(2): 153-157.
10-DEACETYLBACCATIN-III	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
11-METHOXY-KOPSILONGINE	IC50=1.6 ug/ml	Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
12-METHOXY-PLEIOCARPINE	IC50=21 ug/ml	Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
13-ACETYL-BREVIFOLIOL	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
19-ACETYL-19-DEBENZOYLTAXININE-M	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
1BETA-HYDROXYBACCATIN-1	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2',7-DIDEACETOXYAUSTROSPICATINE	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2,9-DIDEACETYLTAXININE	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DEACETOXYAUSTROSPICATINE	1 ug/mL	Kobayashi, J., et al. 1994. Taxuspines A-C, New Taxoids From Japanese New Taxus cuspidata Inhibiting Drug Transport Activityof P-Glycoprotein in Multidrug-Resistant Cells. Tetrahedron, 50(25): 7401-7416.
2-DEACETOXYTAXININE-E	10 ug/ml	Duke, 1992 *
2-DEACETOXYTAXININE-J	1 ug/mL	Kobayashi, J., et al. 1994. Taxuspines A-C, New Taxoids From Japanese New Taxus cuspidata Inhibiting Drug Transport Activityof P-Glycoprotein in Multidrug-Resistant Cells. Tetrahedron, 50(25): 7401-7416.
2-DEACETYL-5-DECINNAMOYLTAXININE-J	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DEACETYLTAXININE-J	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DECINNAMOYLTAXININE-J	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
5'-METHOXYHYDNOCARPIN	not available	Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., Lewis, K. 2000. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA, 97(4): 1433-1437.
5-N-ACETYLARDEEMIN	10 uM	Karwowski, J. P., et al. 1993. 5-n-acetylkardeemin, a Novel Heterocyclic Compound Which Reverses Multiple Drug Resistance in Tumor Cells I. Taxonomy and Fermentation of the Producing Organism and Biological Activity. J Antibiot, 46(3): 374-379.
7-EPITAXOL	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
7-O-ACETYLTAXINE-A	1 ug/mL	Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.