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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-2-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
CIRSIMARITIN IC>50=1,000 uM *
CURCUMIN 10-20 uM *
CYANIDIN-3-O-GLUCOSIDE IC59=100 ug/ml *
EICOSAPENTAENOIC-ACID 1 uM *
EMODIN *
EUGENOL IC50=129 uM *
EUGENOL IC>97=1,000 uM *
EVODIAMINE 2.5 ug/ml Kang, S. S., Kim, J. S., Son, K. H., Kim, H. P., Chang, H. W. 1999. Cyclooxygenase-2 Inhibitor from Evodia rutaecarpa. Nat. Prod. Sci., 5(2): 65-69.
EVODOL 2.5 ug/ml Kang, S. S., Kim, J. S., Son, K. H., Kim, H. P., Chang, H. W. 1999. Cyclooxygenase-2 Inhibitor from Evodia rutaecarpa. Nat. Prod. Sci., 5(2): 65-69.
FLAVOKAWAIN-B IC16=100 ug/ml *
HUMULONE Yamamoto, Wang, et al. 2000. Federation of European Biochemical Societies. (per e-mail with Tom Newmark)
ISOTHYMONIN IC>37=1,000 uM *
KAEMPFEROL *
LAURIC-ACID IC20=100 *
MELATONIN Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=8 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
OLEANOLIC-ACID IC50=295 uM/ *
OLEANOLIC-ACID Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215.
PARTHENOLIDE Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
PINOSTROBIN IC7=100 ug/ml *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Yucca baccata Spanish Bayonet; Yucca; Banana Yucca; Blue Yucca 1 0
Yucca schidigera Mohave Yucca 1 110
Zanthoxylum alatum Indian Prickly Ash; Wartara Oil Tree 1 0
Zanthoxylum americanum Northern Prickly Ash 1 0
Zanthoxylum clava-herculis Pepperbark; Southern Prickly Ash; Hercules'-Club; West Indian Yellowwood 1 0
Zea mays Corn 6 3.2009999881265685
Zingiber officinale Ginger 8 8, 165.0010000000475
Zizyphus jujuba Da-Zao; Jujube; Ta-Tsao 3 2, 100
Zizyphus spina-christi Syrian Christ-Thorn 1 0