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Biological Activity COX-2-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
CIRSIMARITIN IC>50=1,000 uM Duke, 1992 *
CURCUMIN 10-20 uM Duke, 1992 *
CYANIDIN-3-O-GLUCOSIDE IC59=100 ug/ml Duke, 1992 *
EICOSAPENTAENOIC-ACID 1 uM Duke, 1992 *
EMODIN not available Duke, 1992 *
EUGENOL IC50=129 uM Duke, 1992 *
EUGENOL IC>97=1,000 uM Duke, 1992 *
EVODIAMINE 2.5 ug/ml Kang, S. S., Kim, J. S., Son, K. H., Kim, H. P., Chang, H. W. 1999. Cyclooxygenase-2 Inhibitor from Evodia rutaecarpa. Nat. Prod. Sci., 5(2): 65-69.
EVODOL 2.5 ug/ml Kang, S. S., Kim, J. S., Son, K. H., Kim, H. P., Chang, H. W. 1999. Cyclooxygenase-2 Inhibitor from Evodia rutaecarpa. Nat. Prod. Sci., 5(2): 65-69.
FLAVOKAWAIN-B IC16=100 ug/ml Duke, 1992 *
HUMULONE not available Yamamoto, Wang, et al. 2000. Federation of European Biochemical Societies. (per e-mail with Tom Newmark)
ISOTHYMONIN IC>37=1,000 uM Duke, 1992 *
KAEMPFEROL not available Duke, 1992 *
LAURIC-ACID IC20=100 Duke, 1992 *
MELATONIN not available Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=8 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
OLEANOLIC-ACID IC50=295 uM/ Duke, 1992 *
OLEANOLIC-ACID not available Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215.
PARTHENOLIDE not available Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
PINOSTROBIN IC7=100 ug/ml Duke, 1992 *
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Rubus idaeus Red Raspberry; Raspberry 7 242
Rumex acetosa Garden Sorrel 3 1, 100
Rumex acetosella Sheep Sorrel 1 0
Rumex crispus Curly Dock; Lengua De Vaca; Yellow Dock; Sour Dock 4 11, 868
Ruscus aculeatus Butcher's Broom; Box-Holly 1 26
Ruta graveolens Rue 1 0
Salix alba White Willow 5 0
Salvia officinalis Sage 8 102, 311
Salvia sclarea Clary Sage 3 34, 000
Salvia sp. Chia 1 306
Salvia tomentosa Sage 1 0
Salvia triloba Greek Sage 2 84, 900
Sambucus canadensis American Elder; Elderberry; American Elderberry; Sweet Elder 3 72
Sambucus nigra European Alder; European Elder; European Elderberry; Elder; Black Elder 7 6, 530
Sambucus simpsonii Simpson's elderberry 1 0
Sanguinaria canadensis Bloodroot 1 0
Sanguisorba minor Small Burnet 3 0
Sanguisorba officinalis Greater Burnet 4 0
Santalum album White Sandalwood 1 0
Santolina chamaecyparissus Lavender Cotton 1 0