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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Biological Activity Antimalarial

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-1,2-DEHYDROTELOBINE IC50=0.26-0.31 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-2-N-METHYLTELOBINE IC50=0.09-0.26 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-2-NOR-CEPHARANTHINE IC50=0.05-0.13 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-2-NOR-ISOTETRANDRINE IC50=0.05-0.07 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-2-NOR-OBABERINE IC50=0.05-0.09 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-2-NOR-THALRUGOSINE IC50=0.07-0.13 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-AROMOLINE IC50=0.67 ug/ml (ca 1/5 chloroquine) *
(+)-CEPHARANTHINE IC50=0.14-0.30 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-CRINAMINE IC50=2.8-3.4 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-DEPHNANDRINE IC50=0.06-0.22 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-HOMOAROMOLINE IC50=0.02-0.29 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-ISOTETRANDRINE IC50=0.05-0.17 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-OBABERINE IC50=0.22-0.23 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-STEPHIBABERINE IC50=0.13-0.31 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-TETRANDRINE IC50=0.16-0.18 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(+)-THALRUGOSINE IC50=0.06-0.23 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(-)-ANONAINE IC50=1290-1900 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(-)-ASIMILOBINE IC50=470-950 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(-)-CAPAURINE IC50=1910-4340 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
(-)-CASSYTHICINE IC50=2260-2290 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Lycoris squamigera Magic Lily; Resurrection Lily 1 0
Lythrum salicaria Purple Loosestrife 1 0
Machaerocereus gummosus 1 4, 000
Macleaya cordata Plume Poppy 1 0
Maclura pomifera Osage-Orange; Hedge Apple 4 7, 928
Madhuca microphylla 1 930
Madhuca nerifolia 1 560
Magnolia denudata Hsin-I; Xin-Yi 3 0
Magnolia kobus Hsin-I; Xin-Yi 2 1, 000
Magnolia officinalis Chinese Magnolia; Hou Pu; Magnolia-Bark 1 0
Mahonia aquifolium Oregon Grape; Blue Barberry; Holly Barberry; Holly Mahonia; Mountain Grape 8 195
Mahonia bealei 1 5, 000
Mahonia fargesii 3 0
Mahonia fortunei 2 0
Mahonia gracilipes 4 0
Mahonia japonica Japanese Ashberry; Hiiragi-Nanten 4 0
Mahonia nervosa Oregon Barberry; Oregon Grape-Holly; Oregon Grape; Water Holly 1 0
Mahonia philipinensis 2 0
Mahonia repens Creeping Barberry; Oregon Barberry; Oregon Grape-Holly; Oregon Grape 6 11, 588
Mahonia siamensis 2 4, 600