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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
KUWANON-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICORICIDIN 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICURASIDE IC50=0.56 uM *
LINARIIN IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LINARIN IC20=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LONICERIN IC56=1uM; IC92=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN IC50=0.45 uM rat *
LUTEOLIN EC=3 ppm Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.
LUTEOLIN-7-GLUCOSIDE IC31=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCOSIDE IC73=10 uM *
LUTEOLIN-7-GLUCURONIDE IC68=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC88=10 uM *
LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDURONIC-ACID IC50=3.1 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
MACROCARPAL-A IC50=2 uM *
MACROCARPAL-A IC50=10 uM *
MACROCARPAL-B IC50=2.8 uM *
MACROCARPAL-D IC50=2 uM *
MACROCARPAL-G IC50=2.7 uM *
MANDSHURIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
MANIFLAVONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Laburnum alpinum 1 0
Laburnum anagyroides Golden Chain Tree 1 0
Lactuca sativa Lettuce 6 3, 000
Lagenaria siceraria Calabash Gourd; White-Flowered Gourd 1 5, 190
Lagerstroemia indica Crape Myrtle 2 0
Lantana camara Lantana; Wild Sage 2 3, 200
Larrea tridentata Chaparral; Creosote Bush 1 1, 520
Laurus nobilis Bayleaf; Sweet Bay; Grecian Laurel; Bay Laurel; Laurel; Bay 18 1, 753, 212
Lavandula angustifolia English Lavender 8 13, 750
Lavandula latifolia Aspic; Broad-Leaved Lavender; Spike Lavender 6 22, 521
Lavandula x hybrida Hybrid Lavender 4 435
Lavandula x intermedia Dutch Lavender; Lavandin 8 11, 240
Lawsonia inermis Henna; Mignonette; Jamaica-Mignonette; Mignonette Tree 6 10, 232
Ledum palustre Marsh Tea; Wild Rosemary 3 0
Lembotropis emerifolia 1 0
Lens culinaris Lentil 3 700
Leonotis leonurus Lion's Ear 2 2.100000001490116
Leonurus cardiaca Motherwort 7 242
Lepechinia calycina Epling's Lepechinia 6 670
Lepechinia schiediana Schiede's Lepechinia 1 200