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Biological Activity Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
EMBININ IC13=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
EMODIN IC50=15.9 uM Duke, 1992 *
ETHYL-BREVIFOLIN-CARBOXYLATE IC50=5 uM Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
EUGENOL-BETA-D-GLUCOSIDE 0.1 mM/l rat (weak activity, 35.2% inhibition) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
EUPATILIN IC50=25 uM rat (weak activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
FLAVOCANNABISIDE not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
FLAVOSATIVASIDE not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
FORSYTHOSIDE-B IC50=4.83 uM Andary, C. Caffeic Acid Glycoside Esters and Pharmacology. Polyphenolic Phenom, 1993: 237-245.
FRAXIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
FRAXINOL 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
GAMMA-TERPINENE 100 ug/ml Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
GENISTEIN IC50=10 uM Duke, 1992 *
GOSSYPETIN-8-GLUCOSIDE not available Duke, 1992 *
GOSSYPOL not available Deck, L. M., Vander Jagt, D. L., Royer, R. E. 1991. Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors. J Med Chem, 34(1): 3301-3305.
GUAIJAVERIN IC50=0.18 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
HAEMATOXYLIN not available Duke, 1992 *
HERNIARIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
HISPIDULOSIDE ED50=1-10 uM Duke, 1992 *
HYMENOXIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
HYPERIN not available Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Annona reticulata Custard Apple 2 1, 400
Annona squamosa Sugar-Apple; Sweetsop 1 3, 200
Anogeissus latifolia Gum Ghatti 3 0
Anthriscus cerefolium Chervil 1 0
Apios americana not available 1 12
Apium graveolens Celery 20 304, 036
Arachis hypogaea Groundnut; Peanut 10 9, 704
Aralia cordata Udo 4 1, 094.75
Araucaria bidwillii Monkey puzzle 3 0
Arbutus unedo Arbutus; Strawberry Tree 1 0
Arctium lappa Gobo; Great Burdock; Burdock 5 8, 266.800018310547
Arctostaphylos uva-ursi Bearberry; Uva Ursi 14 26, 382
Ardisia japonica Marlberry 3 0
Areca catechu Betel Nut; Pin-Lang 1 0
Argemone mexicana Prickly Poppy 1 1, 680
Argyrocytisus battandieri not available 1 0
Armoracia rusticana Horseradish 7 32, 811
Arnica montana Leopard's-Bane; Mountain Tobacco 5 0
Arracacia xanthorrhiza Arracacha; Peruvian Carrot 1 2, 140
Artemisia abrotanum Southernwood 6 0