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Biological Activity Aldose-Reductase-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
EMBININ IC13=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
EMODIN IC50=15.9 uM Duke, 1992 *
ETHYL-BREVIFOLIN-CARBOXYLATE IC50=5 uM Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
EUGENOL-BETA-D-GLUCOSIDE 0.1 mM/l rat (weak activity, 35.2% inhibition) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
EUPATILIN IC50=25 uM rat (weak activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
FLAVOCANNABISIDE not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
FLAVOSATIVASIDE not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
FORSYTHOSIDE-B IC50=4.83 uM Andary, C. Caffeic Acid Glycoside Esters and Pharmacology. Polyphenolic Phenom, 1993: 237-245.
FRAXIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
FRAXINOL 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
GAMMA-TERPINENE 100 ug/ml Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
GENISTEIN IC50=10 uM Duke, 1992 *
GOSSYPETIN-8-GLUCOSIDE not available Duke, 1992 *
GOSSYPOL not available Deck, L. M., Vander Jagt, D. L., Royer, R. E. 1991. Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors. J Med Chem, 34(1): 3301-3305.
GUAIJAVERIN IC50=0.18 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
HAEMATOXYLIN not available Duke, 1992 *
HERNIARIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
HISPIDULOSIDE ED50=1-10 uM Duke, 1992 *
HYMENOXIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
HYPERIN not available Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Bursera delpechiana Lignaloe; Linaloe 2 21, 120
Byrsonima crassifolia Nance 1 9, 275
Caesalpinia pulcherrima Bird Of Paradise 4 0
Cajanus cajan Pigeonpea 2 2, 880
Cajanus scarabaeoides not available 1 3
Calamintha nepeta Turkish Calamint 4 167
Calathea macrosepala Chufle 1 910
Calea zacatechichi Bitter Grass; Dog's Grass; Mexican Calea 1 0
Calendula officinalis Calendula; Pot-Marigold 10 6, 200.680000007153
Calicotome spinosa not available 1 0
Calicotome villosa not available 1 0
Callicarpa americana American Beauty Berry; Beauty Berry; French Mulberry 4 28.650000035762787
Calopogonium caeruleum not available 1 0
Camellia sinensis Tea 24 78, 700
Camptosema sp not available 1 12
Camptotheca acuminata Happy Tree 2 0
Cananga odorata Cananga; Ylang-Ylang 3 0
Canarium indicum Java-Olive; Manila Elemi 2 14, 000
Canavalia ensiformis Jack Bean 2 1, 517
Canavalia eurycarpa not available 1 5