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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ASTRAGALIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ASTRAGALIN IC30=1 uM *
AURANTIOBTUSIN IC50=13.6 uM *
AVICULARIN IC32=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AVICULARIN IC84=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AXILLARIN IC80=0.1 uM *
AXILLARIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
BAICALEIN IC50=0.98 rbt Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALEIN IC50=0.98 ppm Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALEIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BAICALIN IC50=13.6 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
BAICALIN IC42=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BERBERINE-CHLORIDE IC100=14 nM *
BERBERINE-IODIDE IC100=33 nM *
BERBERINE-SULFATE IC100=13.5 nM *
BRAZILIN ED50=100 uM *
BREVIFOLIN-CARBOXYLIC-ACID IC50=2.4 uM Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
CAFFEIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
CAPILLARISIN IC50=0.22 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
CAPILLARISIN 10 uM rat Yamaguchi, T., Ueda, T., Sata, S., Mihashi, H. 1989. Aldose Reductase Inhibitors for Treatment of Diabetic Diseases. Patent, Japan Kokai Tokkyo Koho-01 228,914. 5pp.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Pycnanthemum beadlei Beadle's Mountain Mint 2 77
Pycnanthemum californicum California Mountain Mint 3 252
Pycnanthemum clinopodioides Clinopod Mountain Mint 3 1, 100
Pycnanthemum curvipes Curved Mountain Mint 1 63
Pycnanthemum incanum Hoary Mountain Mint 3 114
Pycnanthemum loomisii Loomis' Mountain Mint 5 3, 948
Pycnanthemum montanum Montane Mountain Mint 2 72
Pycnanthemum muticum Muticous Mountain Mint 2 500
Pycnanthemum pilosum Pilose Mountain Mint 3 1, 120
Pycnanthemum pycnanthemoides Typical Mountain Mint 3 2, 204
Pycnanthemum setosum Setose Mountain Mint 2 1, 984
Pycnanthemum tenuifolium Slenderleaf Mountain Mint 5 6, 180
Pycnanthemum torreyi Torrey's Mountain Mint 2 230
Pycnanthemum verticillatum Whorled Mountain Mint 2 441
Pycnanthemum virginianum Virginia Mountain Mint 3 1, 769
Pyrus communis Pear 3 20, 062
Quararibea cordata Chupa-Chupa; Sapote 1 1, 320
Quercus alba White Oak 3 127
Quercus infectoria Aleppo Oak; Dyer's Oak; Gall Oak 3 0
Quercus robur English Oak 1 0