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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
7-O-ACETYL-8-EPI-LOGANIC-ACID Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
8,9-DIHYDROXY-3-METHOXYCOUMESTAN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
8-METHOXY-CIRSILINEOL 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
ACACETIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ACACETIN-7-O-(6''-ALPHA-L-RHAMNOPYRANOSYL)-BETA-D-GLUCOPYRANOSIDE IC50=4.7 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
ACARBOSE 0.4 g/kg diet rat Cohen-Melamed, E., Nyska, A., Pollack, A., Madar, Z. 1995. Aldose Reductase (EC 1.1.1.21) Activity and Reduced-Glutatione Content in Lenses of Diabetic Sand Rats (Psammomys obesus) Fed with Acarbose. Brit J Nutr, 74(5): 607-615.
ACETOSIDE IC50=0.4 ppm Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
ACETYL-TRISULFATE-QUERCETIN IC50=0.1 uM *
ACTEOSIDE IC50=0.39 uM Murata, M., Yamakoshi, Y., Homma, S., Arai, K., and Nakamura, Y. 1992. Macrocarpals, Antibacterial Compounds from Eucalyptus, Inhibit Aldose Reductase. Biosci. Biotech. Biochem., 56(12): 2062-2063, 1992.
AESCULETIN IC50=0.74 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
AESCULIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ALLO-CYMENE 100 ug/ml (weak activity) Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
ALLOCRYPTOPINE IC50=27.9 uM rat Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.
ALPHA-TERPINENE 100 ug/ml Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
ALPHA-TERPINEOL 100 ug/ml Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
AMENTOFLAVONE IC25=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
APIIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ARENARIOSIDE IC50=2.38 uM Andary, C. Caffeic Acid Glycoside Esters and Pharmacology. Polyphenolic Phenom, 1993: 237-245.
ASCORBIC-ACID Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000.
Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95
ASTILBIN 60 uM pig Haraguchi, H., Ohmi, I., Masuda, H., Tamura, Y., Mizutani, K., Tanaka, O., Chou, W. H. 1996. Inhibition of Aldose Reductase by Dihydroflavonols in Engelhardtia chrysolepis and Effects on Other Enzymes. Experientia, 52(6): 564-567.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Rhynchosia phaseoloides 1 6
Rhynchosia pyramidalis 1 10
Rhynchosia volubilis 1 5
Ribes nigrum Black Currant 15 129, 064
Ribes rubrum Red Currant; White Currant 2 5, 108
Ribes uva-crispa Gooseberry 3 2, 397
Ricinus communis Castorbean 9 4, 000
Robinia pseudoacacia Black Locust 6 40, 000
Rollinia mucosa Biriba; Lancewood 1 2, 900
Rosa canina Rose; Dogbrier; Dog Rose 7 62, 250
Rosa centifolia Cabbage Rose 2 0
Rosa damascena Damask Rose 6 15, 000
Rosa gallica French Rose 3 8, 470
Rosa multiflora Multiflora Rose 6 2, 000
Rosa rubiginosa Rosa Mosqueta 1 12, 500
Rosa spp Rose Hips 3 12, 500
Rosmarinus eriocalyx Rosemary 5 1, 645.1000000014901
Rosmarinus officinalis Rosemary 17 545, 911
Rosmarinus tomentosus Hairy Rosemary 5 290.1000000014901
Rosmarinus x lavandulaceus Lavender Rosemary 5 1, 330