Biological Activity Aldose-Reductase-Inhibitor | Dr. Duke's Phytochemical and Ethnobotanical Databases

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name	Dosage	Reference
TRIFOLIN	IC19=1 uM	Duke, 1992 *
TRIFOLIN	IC62=10 uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
UMBELLIFERONE	IC50=4.8 ug/ml cow	Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID	100 uM/l	Duke, 1992 *
VERBASCOSIDE	IC50=0.39-15.1 uM	Duke, 1992 *
VITEXICARPIN	100 uM/l	Duke, 1992 *
VITEXIN	5 ug/ml	Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
VITEXIN	IC15=10 uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WARANGALONE	10 uM	Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN	IC50=48 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN	IC13=10uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN-7-O-GLUCURONIDE	IC50=40 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER	IC50=39 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL	10 uM	Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.

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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name	Common Name	Chemical Count	Total Parts Per Million
Ammi visnaga	Visnaga	11	0
Amomum compactum	Round Cardamom; Chester Cardamom; Siam Cardamom; Java Cardamom	2	4, 800
Amomum xanthioides	Bastard Cardamom; Chin Kousha; Malabar Cardamom; Tavoy Cardamom	1	0
Amorphophallus campanulatus	Elephant-Foot Yam	1	279
Amphicarpaea bracteata	Hog Peanut	1	5
Amphicarpaea edgworthii	not available	1	11
Anacardium occidentale	Cashew	3	20, 478
Ananas comosus	Pineapple	4	4, 908
Anastatica hierochuntica	Jericho Rose	3	0
Anemone pulsatilla	Pasque Flower	2	0
Anethum graveolens	Dill; Garden Dill	20	233, 236
Angelica archangelica	Garden Angelica; Angelica; Wild Parsnip	10	2, 193
Angelica dahurica	Bai Zhi	1	0
Angelica sinensis	Dang Gui; Dong Quai; Dang Quai; Dang Qui; Dong Gui; Chinese Angelica	3	1, 824
Aniba rosaeodora	Bois-De-Rose; Cayenne Rosewood	2	0
Anisochilus carnosus	Panjiri-ka Pat	1	0
Annona cherimola	Cherimoya	1	725
Annona diversifolia	Llama	1	140
Annona glabra	Pondapple	1	1, 590
Annona muricata	Soursop	3	1, 540