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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
HYPEROSIDE Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
INDOLE *
IRIDINE IC21=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ISOCHLOROGENIC-ACID-A 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOCHLOROGENIC-ACID-B 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOFRAXIDIN 10 ug/ml cow (weak activity, 18% inhibition) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ISOLIQUIRITIGENIN IC50=0.32 uM *
ISOLIQUIRITIGENIN 0.1 ug/ml *
ISOLIQUIRITIN IC50=0.72 uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
ISOQUERCITRIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ISOSCOPOLETIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
JIOCAROTENOSIDE-A-1 Sasaki, H., Nishimura, H., Morota, T., Katshara, T., Zhengxiong, C., Mitsuhashi, H. 1991. Norcarotenoid Glycosides of Rehmannia glutinosa var. purpurea. Phytochemistry, 30(5): 1639-1644.
JIONOSIDE IC50=0.51uM *
JUGLANIN IC65=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
KAEMPFEROL-3-RHAMNOSIDE IC85=10 uM *
KAEMPFEROL-3-RHAMNOSIDE IC43=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL=3=NEOHESPERIDOSIDE IC30=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KOLAVIRON IC50= 5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
KOLAVIRON IC50=5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Isatis tinctoria Dyer's Woad 2 0
Jasminum officinale Jasmine; Poet's Jessamine 4 570
Jatropha curcas Physic Nut; Purging Nut 1 0
Jatropha gossypifolia Spanish Physic Nut 1 0
Juglans nigra Black Walnut 6 70
Juglans regia English Walnut 11 37, 354.5
Juncus effusus Rush 1 0
Juniperus communis Common Juniper; Juniper 21 11, 600
Juniperus macropoda Himalayan Juniper; Indian Juniper 1 0
Juniperus sabina Sabine 3 0
Juniperus virginiana Red Cedar 2 0
Justicia pectoralis Angel Of Death; Bolek Hena; Curia 3 5, 601
Kalanchoe pinnata Air Plant; Siempre Viva 4 0
Kalanchoe spathulata Beach Bells 2 0
Kalmia latifolia Mountain Laurel; Calico Bush; Spoonwood 1 0
Kennedia coccinea 1 49
Kennedia nigricans 1 24
Kennedia procurrens 1 33
Kennedia rubicunda 1 25
Lablab purpureus Bonavist Bean; Hyacinth Bean; Lablab Bean 1 3, 379.7999954223633