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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
SIDEROXYLONAL-A IC50=1.25 uM Satoh, H., Etoh, H., Watanobe, N., Kawagishi, H., Arai, K., Ina, K. Structures of Sideroxylonals from Eucalyptus sideroxylon. Chem Lett, 1992(10): 1917-1920.
SIDEROXYLONAL-B IC50=2.47 uM Satoh, H., Etoh, H., Watanobe, N., Kawagishi, H., Arai, K., Ina, K. Structures of Sideroxylonals from Eucalyptus sideroxylon. Chem Lett, 1992(10): 1917-1920.
SKULLCAPFLAVONE-II 500 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
SOPHORICOSIDE IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SORBARIN IC70=10uM; IC14=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SPIRAEOSIDE IC9=1 uM *
SPIRAEOSIDE IC51=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SUDACHIIN-A 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUDACHITIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUDACHITIN-7-O-BETA-D-GLUCOSIDE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUGIOL Tezuka, Y., Kasimu, R., Basnet, P., Namba, T., Kadota, S. 1997. Aldose Reductase Inhibitory Constituents of the Root of Salvia miltiorhiza Bunge. Chem Pharm Bull, 45(8): 1306-1311.
TANNIC-ACID IC50=1.8 ug/ml Sawada, H., Hamatake, M., Hara, A., Nakagawa, M., Nakayama, T. 1989. Inhibition of Human Placenta Aldose Reductase by Tannic Acid. Chem Pharm Bull, 37(6): 1662-1664.
TANSHINONE-I IC50=4.8 uM rat *
TANSHINONE-II-A IC50=1.14 uM rat *
TAXIFOLIN 60 uM pig Haraguchi, H., Ohmi, I., Masuda, H., Tamura, Y., Mizutani, K., Tanaka, O., Chou, W. H. 1996. Inhibition of Aldose Reductase by Dihydroflavonols in Engelhardtia chrysolepis and Effects on Other Enzymes. Experientia, 52(6): 564-567.
THERMORUBIN IC50=0.006 uM cow Nakayama, M., et al. 1996. Thermorubin from Cultured Thermoactinomyces UAT-8 as Aldose Reductase Inhibitor and Pharmaceutical Compositions Containing Thermorubin for Diabetic Complications. Patent, Japan Kokai Tokkyo Koho-08 59,462. 5pp.
THIAZOCIN-A IC50=0.455 uM Ozasa, T., Yoneda, T., Hirasawa, M., Suzuki, K., Tanaka, K., Kadota, S., Iwanami, M. 1991. Thiazocins, New Aldose Reductase Inhibitors from Actinosynnema sp. I. Fermentation, Isolation and Characterization. J Antibiot, 44(7): 768-773.
THIAZOCIN-B IC50=0.220 uM Ozasa, T., Yoneda, T., Hirasawa, M., Suzuki, K., Tanaka, K., Kadota, S., Iwanami, M. 1991. Thiazocins, New Aldose Reductase Inhibitors from Actinosynnema sp. I. Fermentation, Isolation and Characterization. J Antibiot, 44(7): 768-773.
THYMONIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
THYMUSIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Prunus spp 1 0
Prunus verecunda 1 0
Pseudeminia comosa 1 4
Pseudoeriosema borianii 1 20
Pseudovigna argentea 1 8
Psidium cattleianum Strawberry Guava 4 2, 100
Psidium guajava Guava 11 66, 493
Psophocarpus tetragonolobus Asparagus Pea; Goa Bean; Winged Bean 1 570
Psoralea corylifolia Babchi; Black Dot; Malaya Tea 4 4, 596.599999427795
Psoralea esculenta Indian Bread-Root; Prairie Apple; Prairie Potato; Indian Turnip; Breadroot; Prairie Turnip 3 1, 026
Pteridium aquilinum Bracken; Bracken Fern 8 3, 160
Pterocarpus angolensis 1 0
Pterocarpus marsupium Indian Kino; Malabar Kino; bijasal 2 0
Ptychopetalum olacoides Muira Puama 4 12, 000
Pueraria montana Kudzu; Kudsu 9 101, 830.79998779297
Pueraria phaseoloides 1 9
Pueraria pseudohirsuta Chinese Kudzu 2 0
Pulsatilla chinensis Chinese Anemone 1 0
Punica granatum Pomegranate; Grenadier (Fr.); Granatapfelbaum (Ger.); Granatapfelstrauch (Ger.); Zakuro (Jap.); Romanzeiro (Port.); Granado (Sp.); Mangrano (Sp.) 16 5, 088
Pycnanthemum albescens White Mountain Mint 1 162