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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
3,3',4-TRI-O-METHYL-ELLAGIC-ACID IC50=0.08 uM Terashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
3,4-DIMETHOXYCINNAMIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
3-(PENTADECA-CIS-8-CIS-11,14-TRIENYL)-PHENOL IC50=180.9 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
3-(PENTADECA-CIS-8-CIS-12-DIENYL)-PHENOL IC50=332.8 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
3-ACETYL-3',4'-DIHYDROXY-5,6,7-TRIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
3-HYDROXY-6-METHOXY-COUMARIN 10 uM (weak activity) Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
3-HYDROXY-COUMARIN 10 uM (weak activity) Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',5,6,7-TETRAHYDROXY-3',8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',5,7-TRIHYDROXY-6,8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',6-DIHYDROXY-3',5,7,8-TETRAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',6-DIHYDROXY-5,7,8-TRIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4'-HYDROXY-3',5,6,7,8-PENTAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4'-HYDROXY-5,6,7,8-TETRAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4-(ALPHA-RHAMNOPYRANOSYL)ELLAGIC-ACID IC50=4.1 x 10(-8) M *
4-HYDROXY-6,7-METHYLENEDIOXY-COUMARIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4-HYDROXYCOUMARIN IC50=0.53 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
4-METHOXYCOUMARIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
4-O-METHYLELLAGIC-ACID *
5,6,7-TRIHYDROXY-8-METHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
5,6-DIHYDROXY-7,8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Lepidium meyenii Maca; Peruvian Ginseng 1 5, 720
Lepidium sativum Garden Cress 1 6, 510
Leptospermum scoparium Manuka; Broom Teatree 3 0
Lespedeza cyrtobotrya 1 0
Levisticum officinale Lovage 8 185
Licania platypus Sansapote 1 1, 005
Ligustrum japonicum Japanese Privet; Ligustri Fructus 4 0
Ligustrum lucidum Chinese Privet; Glossy Privet; Ligustri Fructus; Privet; White Waxtree 4 0
Limonia acidissima Elephant Apple; Manzana De Elefante; Wood-Apple 2 195
Lindera benzoin Benjamin Bush; Spicebush; Wild Allspice; Fieberstrauch (Ger.) 5 1, 320.4000000059605
Linum usitatissimum Flax; Linseed 5 126
Lippia dulcis Sweet Herb 1 0
Lippia graveolens Oregano 1 620
Lippia javanica Lemon Bush; Umsuzwane (Zulu) 2 0
Liquidambar orientalis Oriental Storax; Oriental Styrax 1 300, 000
Liquidambar styraciflua American Styrax; Sweetgum 4 460, 000
Litsea glaucescens Mexican bay 4 365
Lobelia inflata Indian Tobacco; Lobelia 1 4, 504
Lonicera japonica Japanese Honeysuckle 7 60, 100.66500000656
Ludwigia adscendens Ascending ludwigia 1 0