An official website of the United States government.
Plant Podophyllum pleianthum (Berberidaceae)
Download a full report in PDF format
Common name(s)
Chinese Mayapple
How used
Medicinal
Data Views
| # Activity | Chemical Name | Part | Low PPM | High PPM | StdDev | *Reference |
|---|---|---|---|---|---|---|
| 7 | ASTRAGALIN | Rhizome | -- | -- | -- | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
|
ACE-Inhibitor ID50=180 ug/ml rat (24 hr.)
*
Aldose-Reductase-Inhibitor IC30=1 uM
*
Aldose-Reductase-Inhibitor IC62=10 uM
Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
Antileukemic
*
Expectorant
*
Hypotensive
Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
Immunostimulant
*
|
||||||
| 8 | DESOXYPODOPHYLLOTOXIN | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
|
Anticarcinomic 2.6 ppb
*
Antiherpetic
Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.
Antitumor (Nasopharynx)
Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.
Antiviral IC84=1 uM
Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Hepatoprotective
Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 207.
Insecticide
*
Larvicide
*
Pesticide
*
|
||||||
| 0 | DESOXYPODOPHYLLOTOXIN-4'-METHYL-ESTER | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
| 14 | HYPERIN | Rhizome | -- | -- | -- | Chemical Constituents of Oriental Herbs (3 diff. books) |
|
Aldose-Reductase-Inhibitor
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antibacterial
*
Antiinflammatory
*
Antiischemic
*
Antioxidant
*
Antiradicular
*
Antitussive
*
Antiviral
*
Capillarifortificant
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Capillarigenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Diuretic
*
Hepatoprotective IC80=30 ug/ml
Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990.
Hypotensive
*
Pesticide
*
|
||||||
| 30 | HYPEROSIDE | Rhizome | -- | -- | -- | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
|
Aldose-Reductase-Inhibitor
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Analgesic
*
Antiaging
*
Antibacterial MIC=250-500 ug/ml
Planta Medica, 57: A43, 1991.
Anticancer
*
Anticapillary-Fragility
Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.
Antidermatitic
*
Antielastase IC50=0.15 ug/ml
*
Antiflu
Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980.
Antihepatotoxic
Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.
Antiinflammatory 1/4 indomethacin
Planta Medica, 57: A131, 1991.
Antiischemic
*
Antinociceptive
*
Antioxidant IC50=4.6 uM
*
Antiradicular
*
Antitussive
*
Antiviral
*
Antiwrinkle
*
Calcium-Antagonist
*
cAMP-Inhibitor IC50=0.14 mg/ml
Schussler, M., Fricke, U., Nikolov, N., and Holzl, J. 1991. Comparison of the Flavonoids Occurring in Crataegus species and Inhibition of 3',5'-Cyclic Adenosine Monophosphate Phosphodiesterase. Plant Medica 57: Suppl Issue 2. p.A-133.
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Capillarifortificant
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Capillarigenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Cyclooxygenase-Activator 100 uM
Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
Diuretic
*
Hepatoprotective IC80=30 ug/ml
Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990.
Hypotensive ivn dog
*
Pesticide
*
Tissue-Thromboplastin-Inhibitor IC50=20.8 uM
*
Xanthine-Oxidase-Inhibitor
*
|
||||||
| 0 | ISOPICROPODOPHYLLONE | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
| 0 | ISOPICROPODOPHYLLONE-4'-METHYL-ESTER | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
| 75 | KAEMPFEROL | Rhizome | -- | -- | -- | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
|
11B-HSD-Inhibitor
*
5-Lipoxygenase-Inhibitor IC50 (uM)=20
*
Aldose-Reductase-Inhibitor 100 uM
Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
Antiaflatoxin IC50=3.28 ppm
*
Antiaflatoxin IC50=8.73 uM
*
Antiaggregant 30 uM
*
Antiallergic
*
Antibacterial 20 ug/ml
*
Anticancer
*
Antifertility 250 mg/kg/day/60 days/orl rat
Kumar, P., Dixit*, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989.
Antigingivitic 20 ug/ml
*
Antiherpetic 23-92 ug/ml
Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992.
Antihistaminic
Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antiimplantation
*
Antiinflammatory 20 mg/kg
*
Antiinflammatory 200 mg/kg ipr rat
*
Antileukemic IC50=3.1 ug/ml
Life Sciences 55: 1061.
Antilymphocytic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antimutagenic ID50=10-40 nM
Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
Antioxidant 3/4 quercetin
*
Antioxidant IC50=1.2 ug/ml
*
Antioxidant IC50=40 uM
*
Antiperiodontic 20 ug/ml
*
Antiplaque 20 ug/ml
*
Antiradicular 7 x quercetin
*
Antiseptic 20 ug/ml
*
Antiserotonin 200 mg/kg ipr rat
*
Antispasmodic
Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antistaphylococcic
*
Antitumor
*
Antitumor-Promoter
Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990.
Antiulcer 50-200 mg/kg ipr rat
*
Antiviral 23-92 ug/ml
*
Apoptotic 60 uM
*
Aromatase-Inhibitor IC12=1 uM/l
Journal of Medicinal Food 2: 235.1999.
cAMP-Phosphodiesterase-Inhibitor
*
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Carcinogenic
Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu
Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp.
Choleretic
Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Copper-Chelator
*
COX-2-Inhibitor
*
Cyclooxygenase-Inhibitor IC50 (uM) =20
*
Cytotoxic
*
Diaphoretic?
Lawrence Review of Natural Products, Dec-90.
Diuretic
*
Estrogenic EC50=0.56 uM
*
Estrogenic EC50=0.1-25 uM/l
Journal of Medicinal Food 2: 227.1999.
Fungicide 20 ug/ml
Father Nature's Farmacy: The aggregate of all these three-letter citations.
Hepatoprotective IC50=5.46 uM
*
Hepatoprotective IC50=1.30 ppm
*
HIV-RT-Inhibitor IC50=50-150 ug/ml
Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991.
Hypotensive
*
ICAM-1-Inhibitor
*
iNOS-Inhibitor IC50=<15 uM
*
iNOS-Inhibitor IC50=13.9 uM
*
Inotropic
*
Iodothyronine-Deiodinase-Inhibitor
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
JNK-Inhibitor
*
Lipoxygenase-Inhibitor
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
MAO-Inhibitor
*
Mutagenic
*
Natriuretic
*
Neuroprotective
*
NO-Inhibitor IC50=13.9 uM
*
PAF-Inhibitor
*
Pesticide
*
Protisticide
Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105.
Quinone-Reductase-Inducer 3 uM
*
Teratologic
*
TNF-alpha-Inhibitor IC50=3.99 uM
*
Topoisomerase-I-Inhibitor
Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
Topoisomerase-II-Inhibitor IC50=8.1 ug/ml
Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
Tyrosinase-Inhibitor ID50=230 uM
*
Uterotrophic EC50=0.1-25 uM/l
Journal of Medicinal Food 2: 227.1999.
Vasodilator
*
|
||||||
| 26 | PODOPHYLLOTOXIN | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
|
Abortifacient
*
Anticondylomata
Martindale's 29th
Antifertility
Pei-Gen, X., and Nai-Gong, W. Can ethnopharmacology contribute to the development of anti-fertility drugs? Journal of Ethnopharmacology, 32: 167-177, 1991.
Antiherpetic IC88=414 ppb
Bedows, E. and Hatfield, G.M. An Investigation of the Antiviral Activity of Podophyllum peltatum. J. Nat. Prod. 45: 725.
Antileukemic 5.4 ppm
*
Antimeasles
Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Antimelanomic ED50=>20 ug/ml
J. Ethnopharmacology, 32: 117.
Antimitotic
Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176)
Antisarcomic ED50=0.012 ug/ml
J. Ethnopharmacology, 32: 117.
Antitumor 2 ppm iv
*
Antitumor (Breast) ED50=0.041 ug/ml
J. Ethnopharmacology, 32: 117.
Antitumor (Colon) ED50=0.011 ug/ml
J. Ethnopharmacology, 32: 117.
Antitumor (Lung) ED50=0.0181 ug/ml
J. Ethnopharmacology, 32: 117.
Antiviral IC88=1 uM
Bedows, E. and Hatfield, G. M. An investigation of the antiviral activity of Podophyllum peltatum, J. Nat. Prod., 45(6), 1982, 725-9.
Cathartic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Embryocide
Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Fungicide
*
Herbicide 50 ppm
*
Insecticide 1-20 ppm
*
Irritant
Jim Duke's personal files.
Juvabional 1,200 ppm
*
Larvicide 5 ppm
Berenbaum, M. R., The natives knew, Chemtech, (May), 1990, 275-279.
Pesticide
*
Piscicide 1-20 ppm
*
Purgative
*
Topoisomerase-II-Inhibitor 10 ug/ml
*
|
||||||
| 0 | PODOPHYLLOTOXIN-4'-METHYL-ESTER | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
| 1 | PODOPHYLLOTOXONE | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
|
Topoisomerase-II-Inhibitor 10 ug/ml
Figgitt, D. P., Denyer, S. P., Dewick, P. M., Jaackson, D. E., Williams, P. Differential Sensitivity of Fungal Topoisomerases to Podophyllotoxin Derivatives. J Pharm Pharmacol Suppl, 41: 44pp.
|
||||||
| 0 | PODOPHYLLOTOXONE-4'-METHYL-ESTER | Plant | -- | -- | -- | J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991. |
| 176 | QUERCETIN | Rhizome | -- | -- | -- | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
|
11B-HSD-Inhibitor
*
5-Lipoxygenase-Inhibitor IC50 (uM)=4
*
Aldehyde-Oxidase-Inhibitor IC70-96=10 uM
*
Aldose-Reductase-Inhibitor 4 ug/ml
Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
Aldose-Reductase-Inhibitor IC50=0.84 ug/ml cow
Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
Aldose-Reductase-Inhibitor IC50=0.344 uM
Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.
Aldose-Reductase-Inhibitor 100 uM
*
Allelochemic IC82=1 mM
Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Allergenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Analgesic
*
Antiaflatoxin IC50=25 uM
*
Antiaflatoxin IC50=7.5 ppm
*
Antiaggregant IC50=55 uM
Economic & Medicinal Plant Research, 5: 333.
Antiaggregant 30 uM
*
Antiaging
*
Antiallergic IC50=14 uM
Jim Duke's personal files.
Antialzheimeran
*
Antianaphylactic
Meli, R., Autore, G., Di Carlo, G., Capasso, F. Inhibitory Action of Quercetin on Intestinal Transit in Mice. Phytotherapy Research 4(5): 201, 1990.
Antiangiogenic
*
Antiarthritic
*
Antiasthmatic IC50=14 uM
*
Antiatherosclerotic
*
Antibacterial
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Anticarcinomic (Breast) IC50=1.5 uM
Medline (post 1990 searches filed in my computer)
Anticariogenic ID50=120 ug/ml
*
Anticataract
*
Anticolitic 400 mg/man/3x/day
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Anticomplementary
*
AntiCrohn's 400 mg/man/3x/day
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Anticystitic 1,000 mg/day/4 weeks
*
Antidepressant
*
Antidermatitic
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antidiabetic
*
Antielastase IC50=0.8 ug/ml
*
Antiencephalitic
Economic & Medicinal Plant Research, 5: 199.
Antiescherichic
*
Antiestrogenic
*
Antifeedant IC52=<1,000 ppm diet
Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Antifibrosarcomic
*
Antiflu
Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Antigastric
Rastitel'nye Resursy, 21: 85.
Antigonadotropic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
AntiGTF ID50=120 ug/ml
*
Antihepatotoxic
Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990.
Antiherpetic 48-150 ug/ml
*
Antihistaminic IC50=<10 uM
*
AntiHIV
*
Antihydrophobic
Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Antihypertensive
Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Antiinflammatory 20-150 mg/kg
Fitoterapia No.5-1990.
Antileishmanic IC50=64
*
Antileukemic 5.5-60 uM
*
Antileukemic IC50=10 uM
Economic & Medicinal Plant Research, 5: 225.
Antileukemic IC50=>10 ug/ml
Life Sciences 55: 1061.
Antileukotriene
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antilipoperoxidant IC67=50
*
Antimalarial IC50=1-6.4 ug/ml
Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987.
Antimelanomic
*
Antimetastatic
*
Antimutagenic ID50=0.62 ug/ml
*
Antimutagenic ID50=2-5 nM
Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
Antimyocarditic
Economic & Medicinal Plant Research, 5: 199.
Antinitrosaminic
*
Antinociceptive
*
Antioxidant 4.7 x Vit. E
*
Antioxidant IC47=10 uM
*
Antioxidant ED50=2.3 uM
Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98.
Antioxidant IC96=300 ppm
Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
Antipancreatitic
Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Antiperiodontal
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiperistaltic
*
Antipermeability
*
Antiperoxidant
Planta Medica, 57: A110, 1991.
Antipharyngitic
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiplaque
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiplasmodial IC50=13-64
*
AntiPMS 500 mg/2x/day/wmn
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antipodriac
*
Antipolio
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiproliferant 10 nM
*
Antiprostanoid
*
Antiprostatitic
Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Antipsoriac
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiradicular IC50=4.6 uM
Planta Medica, 56(6): 695, 1990.
Antispasmodic
*
Antistreptococcic ID50=120 ug/ml
*
Antithiamin
Phenolic Compounds in Food and Their Effects on Health, 69.
Antithrombic
*
Antitrypanosomic IC50=13
*
Antitumor 10 uM
*
Antitumor (Bladder)
*
Antitumor (Breast)
*
Antitumor (Colon)
*
Antitumor (Lung)
*
Antitumor (Ovary)
*
Antitumor (Skin) 20 uM
*
Antitumor-Promoter
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiulcer
*
Antiviral IC50=10 uM
Economic & Medicinal Plant Research, 5: 225.
Antiviral 48-150 ug/ml
Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992.
Apoptotic 20-60 uM
*
ATPase-Inhibitor
Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Bacteristat 10 mg/ml
*
Bradycardiac
Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Calmodulin-Antagonist
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
cAMP-Phosphodiesterase-Inhibitor
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Candidicide
*
Capillariprotective
Merck 11th Edition
Carcinogenic 40,000 ppm (diet) mus
Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Catabolic
*
COMT-Inhibitor
*
Copper-Chelator
*
COX-2-Inhibitor <40 uM
*
Cyclooxygenase-Inhibitor
*
Cytochrome-P450-1A2-Inhibitor
*
Cytotoxic ED50=70 ug/ml
Matsukawa, Y., et al. The Effect of Quercetin and Other Flavonoids on Cell Cycle Progresssion and Growth of Human Gastric Cancer Cells. Planta Medica, 56(6): 677, 1990.
Cytotoxic IC82=100 ug/ml
Planta Medica, 57: A113, 1991.
Deiodinase-Inhibitor
Jim Duke's personal files.
Diaphoretic?
Lawrence Review of Natural Products, Dec-90.
Differentiator 5.5 uM
*
Estrogenic 10% genistein
*
Fungicide
*
Glucosyl-Transferase-Inhibitor ID50=120 ug/ml
*
Hemostat
Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Hepatomagenic 5,000 ppm (diet) rat
Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
Hepatoprotective
*
HIV-RT-Inhibitor IC50=<1 ug/ml
Nakane, H., Fukushima, M., and Ono*, K. Differential Inhibition Of Reverse Transcriptase And Various DNA Polymerases By Digallic Acid And Its Derivatives. Journal of Natural Products, 53(5): 1234-1240, 1990.
Hypoglycemic 100 mg/kg orl rat
Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.
iNOS-Inhibitor IC50=20 uM
*
Inotropic
*
Insulinogenic
Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Juvabional
Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Larvistat 8,000 ppm diet
Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Lipoxygenase-Inhibitor IC11=1.25 mM
Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.
Lipoxygenase-Inhibitor IC50=0.1-5 uM
*
MAO-A-Inhibitor
*
Mast-Cell-Stabilizer
*
Metal-Chelator (Copper)
Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98.
Metalloproteinase-Inhibitor IC50=>42 uM
*
MMP-9-Inhibitor 20 uM
*
Mutagenic
*
NADH-Oxidase-Inhibitor
*
NEP-Inhibitor IC50=>42 uM
*
Neuroprotective 5-25 uM
*
NF-kB-Inhibitor
*
NO-Inhibitor IC50=20 uM
*
NO-Inhibitor IC>50=125 uM
*
NO-Synthase-Inhibitor 5-50 uM
*
Ornithine-Decarboxylase-Inhibitor <10 uM
*
P450-Inducer 5 uM
Father Nature's Farmacy: The aggregate of all these three-letter citations.
P450-Inhibitor 50-100 uM
Father Nature's Farmacy: The aggregate of all these three-letter citations.
Pesticide
*
PGE2-Inhibitor
*
Phospholipase-Inhibitor
*
Plasmodicide
Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
Proliferant
*
Prostaglandin-Synthesis-Inhibitor 40 ug/ml
Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
Protein-Kinase-C-Inhibitor
Naim, M., Zehavi, U., Nagy, S., and Rouseff, R.L. Hydroxycinnamic Acids as Off-Flavor Precursors in Citrus Fruits and Their Products. Phenolic Compounds in Food and Their Effects on Health, Ch.14.
PTK-Inhibitor 0.4-24 uM
*
Quinone-Reductase-Inducer 6 uM
Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
Quinone-Reductase-Inducer 13 uM
*
Teratologic
*
TNF-alpha-Inhibitor IC50=3.11 uM
*
Topoisomerase-I-Inhibitor IC50=12.8 ug/ml
*
Topoisomerase-I-Inhibitor IC50=42 uM
*
Topoisomerase-II-Inhibitor IC50=23-40 uM
*
Topoisomerase-II-Inhibitor IC50=1-6.9 ug/ml
*
Tumorigenic 0.1% diet orl rat/yr
Jim Duke's personal files.
Tyrosinase-Inhibitor ID50=70 uM
*
Tyrosine-Kinase-Inhibitor
Economic & Medicinal Plant Research, 6: 170.
Vasodilator
*
VEGF-Inhibitor
*
Xanthine-Oxidase-Inhibitor IC50=>0.4 ug/ml
Chem. & Pharm. Bull. 38: 1772.
Xanthine-Oxidase-Inhibitor IC50=10.6 ug/ml
*
Xanthine-Oxidase-Inhibitor 3.1 uM
*
|
||||||
| # Activity | Chemical Name | Part | Low PPM | High PPM | StdDev | *Reference |
|---|
| # Chemical | Activity Name | *Reference |
|---|---|---|
 |
||
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.