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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. PODOPHYLLOTOXIN

PODOPHYLLOTOXIN

Chemical ID
PODOPHYLLOTOXIN
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=15 (ipr rat) Merck 11th Edition
LD50=8.7 (ivn rat) Merck 11th Edition
LD50=90 (orl mus) Jim Duke's personal files.
LD50=4 ims cat De Smet, P.A.G.M., Keller, K., Hansel, R. and Chandler, R.F., eds. 1993. Adverse Effects of Herbal Drugs 2. Springr-Verlag, Berlin. 348pp.
LD50=3 ims rat De Smet, P.A.G.M., Keller, K., Hansel, R. and Chandler, R.F., eds. 1993. Adverse Effects of Herbal Drugs 2. Springr-Verlag, Berlin. 348pp.
LD50=33 ipr mus De Smet, P.A.G.M., Keller, K., Hansel, R. and Chandler, R.F., eds. 1993. Adverse Effects of Herbal Drugs 2. Springr-Verlag, Berlin. 348pp.
LD50=1.7 ivn cat De Smet, P.A.G.M., Keller, K., Hansel, R. and Chandler, R.F., eds. 1993. Adverse Effects of Herbal Drugs 2. Springr-Verlag, Berlin. 348pp.
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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Abortifacient *
Anticondylomata Martindale's 29th
Antifertility Pei-Gen, X., and Nai-Gong, W. Can ethnopharmacology contribute to the development of anti-fertility drugs? Journal of Ethnopharmacology, 32: 167-177, 1991.
Antiherpetic IC88=414 ppb Bedows, E. and Hatfield, G.M. An Investigation of the Antiviral Activity of Podophyllum peltatum. J. Nat. Prod. 45: 725.
Antileukemic 5.4 ppm *
Antimeasles Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Antimelanomic ED50=>20 ug/ml J. Ethnopharmacology, 32: 117.
Antimitotic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176)
Antisarcomic ED50=0.012 ug/ml J. Ethnopharmacology, 32: 117.
Antitumor 2 ppm iv *
Antitumor (Breast) ED50=0.041 ug/ml J. Ethnopharmacology, 32: 117.
Antitumor (Colon) ED50=0.011 ug/ml J. Ethnopharmacology, 32: 117.
Antitumor (Lung) ED50=0.0181 ug/ml J. Ethnopharmacology, 32: 117.
Antiviral IC88=1 uM Bedows, E. and Hatfield, G. M. An investigation of the antiviral activity of Podophyllum peltatum, J. Nat. Prod., 45(6), 1982, 725-9.
Cathartic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Embryocide Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Fungicide *
Herbicide 50 ppm *
Insecticide 1-20 ppm *
Irritant Jim Duke's personal files.
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Hyptis verticillata Leaf 500.0 Tramil
Juniperus sabina Plant *
Juniperus virginiana Leaf *
Podophyllum hexandrum Rhizome 22400.0 81000.0 1.0 ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
Podophyllum peltatum Rhizome 7000.0 12000.0 -1.0 *
Podophyllum pleianthum Plant J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.