Ilex paraguariensis | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Mate, Paraguay Tea, South American Holly

How used

Food

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Activities: 343

Chemicals w/Activities: 24

All Chemicals: 39

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	2,5-XYLENOL	Leaf	--	--	--	*
0	4-OXOLAURIC-ACID	Leaf	--	--	--	*
1	5-O-CAFFEOYLQUINIC-ACID	Leaf	--	--	--	*
Antioxidant *
0	ASH	Leaf	--	42500.0	-1.35	*
0	ASH	Seed	--	13000.0	-1.05	*
9	BETA-AMYRIN	Leaf	--	--	--	*
Analgesic * Antiedemic IC27=40 mg/kg ipr rat * Antiinflammatory * Antinociceptive * Antiulcer * Gastroprotective * Hepatoprotective * Larvicide * Mosquitocide *
6	BUTYRIC-ACID	Leaf	--	--	--	*
Anticancer Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antitumor Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Apoptotic * Bruchifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Nematistat 880 ug/ml Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pesticide *
62	CAFFEINE	Leaf	2000.0	20000.0	-0.44	*
(+)-Inotropic Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Adenosine-Antagonist McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Analeptic 200 scu mus Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Analgesic-Synergist * Antiapneic Martindale's 29th Antiapoptotic * Antiasthmatic 5-10 mg/kg orl/man Martindale's 29th Anticarcinogenic * Anticariogenic * Antidermatitic Martindale's 29th Antiemetic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antiflu Economic & Medicinal Plant Research, 5: 198. Antiherpetic * Antihypotensive 250 mg/day/orl/man Martindale's 29th Antinarcotic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antiobesity * Antioxidant * Antirhinitic 140 mg/day/orl/man Martindale's 29th Antiserotonergic 40 ipr rat Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Antiserotonergic 40 scu rat Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Antitumor * Antitumor (Lung) * Antivaccinia * Antiviral Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Apoptotic * Arrhythmigenic 1,500 mg/man * cAMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic 10-25 orl dog Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Cardiotonic 65-500 orl cat Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Catabolic Abstract (See species file) cGMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Choleretic * CNS-Stimulant 100 orl mus * CNS-Stimulant 30 orl rat * Coronary-Dilator McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Diuretic * Energizer 20-200 mg/man * Ergotamine-Enhancer Martindale's 29th FLavor FEMA 125 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide * Hypertensive * Hypoglycemic * Insecticide Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Lypolytic Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Myorelaxant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Neurotoxic R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. Pesticide * Phosphodiesterase-Inhibitor * Pyrogenic 60 mg/day oral hmn Daroca, P., Rodriguez, J., Reano, M., Canto, G., Miranda, P. 1996. Fever From Caffeine. Allergy, 51(3): 189-191. Pyrogenic 13.3 mg/kg ipr rbt Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392. Pyrogenic 15 mg/kg ipr cat Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392. Respirastimulant * Spasmogenic 1,500 mg/man * Stimulant R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. Tachycardic 1,500 mg/man * Teratogenic 14 orl rat Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006. Topoisomerase-I-Inhibitor 0.1 nM Tohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132. Topoisomerase-I-Inhibitor 75 uM Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52. Topoisomerase-II-Inhibitor 99 mM Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52. Vasodilator Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
77	CHLOROGENIC-ACID	Leaf	--	--	--	*
Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345. Allelochemic * Allergenic * Analgesic * Antiatherosclerotic * Antibacterial * Anticancer (Colon) * Anticancer (Forestomach) * Anticancer (Liver) * Anticancer (Skin) * Anticarcinogenic * Antidiabetic * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antifeedant * Antigenotoxic * Antigonadotropic Jim Duke's personal files. Antihemolytic 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antihepatotoxic * Antiherpetic Economic & Medicinal Plant Research, 5: 194. Antihistaminic * AntiHIV Economic & Medicinal Plant Research, 6: 189. Antihypercholesterolemic Economic & Medicinal Plant Research, 6: 189. Antihyperthyroid * Antiinflammatory Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. AntiLegionella * Antileukotriene * Antimelanogenic * Antimutagenic * Antinitrosaminic * Antioxidant IC53=200 ppm Huang, M-T., and Ferraro, T. Phenolic Compounds in Food and Cancer Prevention. Phenolic Compounds in Food and Their Effects on Health, Ch.2 p.21. Antioxidant IC80=12 uM * Antioxidant IC50=54.2 uM * Antiperoxidant IC50=36 uM Planta Medica, 57: A54, 1991. Antipolio Jim Duke's personal files. Antiradicular 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antiradicular 9 x quercetin * Antiseptic * Antisunburn * Antithyroid Jim Duke's personal files. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antitumor (Colon) * Antitumor (Forestomach) * Antitumor (Liver) * Antitumor (Skin) * Antitumor-Promoter IC25=10 uM * Antiulcer Economic & Medicinal Plant Research, 6: 189. Antiviral Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Autotoxic * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective * Chemopreventive * Cholagogue Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Choleretic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Clastogenic Friedman, M. and Dao, L. 1990. Effect of Autoclaving and Conventional and Microwave Baking on the Ergot Alkaloid and Chlorogenic Acid Contents of Morning Glory (Ipomoea tricolor Cav. cv.) Heavenly Blue Seeds. J. Agric. Food Chem. 38: 805-808. CNS-Active Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. CNS-Stimulant 1/6 Caffeine * Collagen-Sparing * Diuretic * Fungicide Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Hepatoprotective Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Histamine-Inhibitor * Hypoglycemic * Immunostimulant * Insectifuge Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994. Interferonogenic Economic & Medicinal Plant Research, 1: 124. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Larvistat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Leukotriene-Inhibitor * Lipoxygenase-Inhibitor IC23=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. NO-Genic * Ornithine-Decarboxylase-Inhibitor Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. Oviposition-Stimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Sunscreen * Sweetener Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Vulnerary *
21	CHLOROPHYLL	Leaf	--	19000.0	-0.24	*
Antibacterial * Anticancer Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Colon) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Liver) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Antidecubitic * Antihalitosic * Antimenorrhagic 25 mg/day/wmn/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antimutagenic Lawson, T., J. Nunnaly, B. Walker, E. Bresnick, D. Wheeler, and M. Wheeler. 1989. Isolation of compounds with antimutagenic activity from savoy chieftain cabbage. J. Agric. Food Chem. 37:1363-1367. Antiotitic * Antioxidant * Antirhinitic * Antisinusitic * Antiulcer * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Colorant Martindale's 28th Deodorant Merck 11th Edition Dye * Oxidant * Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Vulnerary *
20	CHOLINE	Leaf	--	--	--	*
Antialzheimeran 5-16 g/man/day * Antichoreic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anticirrhotic 6,000 mg/man/day * Anticystinuric * Antidementia * Antidiabetic * Antidyskinetic 150-200 mg/kg/man/day Martindale's 28th Antihomocysteine * Antimanic 15-30 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antinociceptive * Antisteatotic * Cardiodepressant * Cerebrotonic * Cholinergic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Hepatoprotective * Hypotensive * Ileorelaxant * Lipotropic * Memorigenic * Parasympathomimetic (1/1,000th acetylcholine) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
0	EO	Leaf	--	3000.0	-0.75	*
0	FAT	Seed	161000.0	173000.0	-0.49	*
15	FIBER	Leaf	--	176800.0	0.19	*
Angiotensin-Receptor-Blocker * Antidiabetic * Antihypertensive * Antiobesity * Antitumor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiulcer Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Beta-Blocker * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective * Diuretic * Hypocholesterolemic * Hypotensive 10 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Hypouricemic * Laxative * Vasodilator *
8	INOSITOL	Leaf	--	--	--	*
Antialopecic * Anticirrhotic * Antidiabetic? Martindale's 29th Antineuropathic? 2 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Cholesterolytic 2,000 mg/man/day * Lipotropic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Sweetener Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ubiquiot Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
2	ISOBUTYRIC-ACID	Leaf	--	--	--	*
Irritant * Transdermal Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253.
0	ISOCAPRONIC-ACID	Leaf	--	--	--	*
5	ISOVALERIC-ACID	Leaf	--	--	--	*
FLavor FEMA 1-16 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Perfumery Merck 11th Edition Sedative * Tranquilizer Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
2	NEO-CHLOROGENIC-ACID	Leaf	--	--	--	*
Antiinflammatory * Vulnerary *
11	NICOTINIC-ACID	Leaf	--	--	--	*
Antichilblain 50 mg/3x/day Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. AntiCrohn's Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (pesticides) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antischizophrenic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antithyrotoxic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Choleretic * Hypocholesterolemic 1-6 g/man/day Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Hypoglycemic * Insulinase-Inhibitor Economic & Medicinal Plant Research, 6: 157. Insulinotonic Economic & Medicinal Plant Research, 6: 157. Lipolytic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Ilex paraguariensis (Aquifoliaceae)

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