Castanea sativa | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

European Chestnut

How used

Food

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Activities: 448

Chemicals w/Activities: 47

All Chemicals: 62

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
3	ALANINE	Seed	1380.0	3036.0	-1.51	*
Antioxidant Larson, R.A. 1987. Review Article Number 30. The Antioxidants of Higher Plants. Phytochemistry. 27: 969-978. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Oxidant Larson, R.A. 1987. Review Article Number 30. The Antioxidants of Higher Plants. Phytochemistry. 27: 969-978.
14	ARGININE	Seed	1451.0	3192.0	-0.91	*
Antidiabetic? Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antiencephalopathic Martindale's 29th Antihepatitic Martindale's 29th Antihypertensive * Antiimpotence * Antiinfertility 4 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antioxidant? * Aphrodisiac 3 g/day * Diuretic * Hypoammonemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NO-Genic * Pituitary-Stimulant * Spermigenic 4 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Vasodilator *
0	ASH	Seed	12300.0	27060.0	-0.63	*
0	ASH	Leaf	--	44000.0	-1.32	*
3	ASPARTIC-ACID	Seed	3381.0	7438.0	-1.35	*
Antimorphinic Martindale's 28th Neuroexcitant Martindale's 28th Roborant Merck 11th Edition
13	BETULIN	Leaf	--	1000.0	-0.03	Jim Duke's personal files.
Anticarcinomic * Antifeedant * Antiflu * AntiHIV 6.1 uM * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 6.1 uM Aphidifuge Lugemwa, F.N., Huang, F-Y., Bentley, M.D., Mendel, M.J., and Alford, A.R. 1990. A Heliothis zea Antifeedant from the Abundant Birchbark Triterpene Betulin. J. Agric. Food Chem. 38(2): 493-494. Cytotoxic 8.6 uM * Cytotoxic 600 ppm * Hypolipemic * Prostaglandin-Synthesis-Inhibitor IC50=119 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626. Topoisomerase-II-Inhibitor IC50=38.6 uM *
102	CAFFEIC-ACID	Leaf	--	--	--	*
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Allergenic * Analgesic * Antiadenoviral Economic & Medicinal Plant Research, 5: 207. Antiaggregant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiaging * Antiatherogenic * Antibacterial * Anticancer * Anticarcinogenic Economic & Medicinal Plant Research, 6: 189. Antidepressant * Antiedemic Economic & Medicinal Plant Research, 6: 189. Antielastase IC50=86 ug/ml (475 uM) * Antielastase IC50=93 um/l * Antiescherichic * Antiflu Economic & Medicinal Plant Research, 5: 207. Antigonadotropic Jim Duke's personal files. Antihemolytic 25 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antihepatoadenomic 200 ppm diet orl mus * Antihepatotoxic * Antiherpetic EC50=>50 ug/ml * Antiherpetic 50 ug/ml * Antihistaminic * AntiHIV EC50=200 ug/ml * Antihypercholesterolemic Economic & Medicinal Plant Research, 6: 189. Antihyperthyroid * Antiinflammatory * AntiLegionella * Antileukemic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antileukotriene * Antimelanogenic * Antimutagenic Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18. Antinitrosaminic Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18. Antiophidic * Antioxidant 1.3 x Vit. E * Antioxidant 50 uM * Antioxidant 1/2 BHA * Antioxidant 1/3 quercetin * Antioxidant 30 mM * Antioxidant IC57=30 ppm * Antiperoxidant IC50=44 uM Planta Medica, 57: A54, 1991. Antiperoxidant IC85=100 ug/ml * Antiperoxidant IC35=200 ug/ml * Antiproliferant Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antiprostaglandin * Antiradicular 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antiradicular 1/3 quercetin * Antiradicular IC50=32-35 uM * Antiradicular 30 mM * Antiseptic * Antispasmodic EC50=3.4-15 uM Phytotherapy Research, 4: 73. Antistaphylococcic * Antistomatitic Economic & Medicinal Plant Research, 5: 207. Antisunburn * Antithiamin Phenolic Compounds in Food and Their Effects on Health, 69. Antithyroid Jim Duke's personal files. Antitumor 200 ppm diet orl mus * Antitumor (Skin) * Antitumor-Promoter IC42=10 uM Cancer Research, 48: 5941. Antiulcerogenic * Antivaccinia Economic & Medicinal Plant Research, 5: 207. Antiviral IC50=62.5 ug/ml * Anxiolytic * Calcium-Antagonist IC50=1.2 uM rbt * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic 2% (diet) * Chemopreventive * Cholagogue Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Choleretic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Clastogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. CNS-Active Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Co-carcinogenic * Collagen-Sparing * COX-2-Inhibitor IC32=100 uM * Cytoprotective Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Cytotoxic TC50=200 ug/ml * Diuretic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. DNA-Active Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Fungicide MIC=0.4 mg/ml * Hepatocarcinogenic 400 ppm diet orl mus (in the absence of alcohol) * Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210. Hepatotropic * Histamine-Inhibitor * Immunostimulant * Insectifuge Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994. Leukotriene-Inhibitor * Lipoxygenase-Inhibitor IC50=62-148 uM * Lipoxygenase-Inhibitor IC27=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Lyase-Inhibitor IC50=94-164 uM * Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Ornithine-Decarboxylase-Inhibitor Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. Pesticide * Prooxidant * Prostaglandigenic * Sedative 500 mg * Sunscreen IC50=2.5 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Sunscreen IC91=5 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Sunscreen IC98=25 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Tumorigenic Jim Duke's personal files. Vulnerary Xanthine-Oxidase-Inhibitor IC50=39.21 uM Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
28	CALCIUM	Seed	220.0	528.0	-0.66	*
Antiallergic 500 mg/day * Antianxiety Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antiarrhythmic 500-1,500 mg * Antiarthritic 1,000 mg/day * Antiatherosclerotic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Anticlimacteric 1,000-1,500 mg/day * Antidepressant Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Aluminum) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Lead) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihyperkinetic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihypertensive * Antiinsomniac Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antimenopausal 1,000-1,500 mg/day * Antiobesity * Antiosteoporotic 500-2,000 mg/day * Antiperiodontitic 750 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. AntiPMS 1 g/day * Antirheumatic 1,000 mg/day * Antistress 500-1,500 mg/day * Antitic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anxiolytic 500-1,500 mg/day * Calcium-Channel-Blocker * Diuretic * Hypocholesterolemic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Hypotensive 1 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Laxative 1,000-1,200 mg * Tranquilizer 500-1,500 mg/day * Vasodilator *
0	CARBOHYDRATES	Seed	402800.0	886160.0	1.44	*
1	CASTALAGIN	Plant	--	--	--	*
Topoisomerase-II-Inhibitor IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
0	CASTALIN	Plant	--	--	--	*
1	CELLULOSE	Seed	--	21000.0	-0.96	*
Hemostat Martindale's 29th
12	COPPER	Seed	2.0	5.0	-0.89	*
Antianemic * Antiarthritic * Antidiabetic 2-4 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antifatigue * Antiinflammatory Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antinociceptive Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antiosteoporotic * Cardioprotective * Contraceptive Martindale's 28th Hypocholesterolemic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Immunomodulator * Schizophrenigenic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.
2	CYSTINE	Seed	628.0	1382.0	-1.23	*
Adjuvant Merck 11th Edition Antihomocystinuric Martindale's 29th
0	DEHYDRODIGALLIC-ACID	Branches	--	5000.0	--	*
51	ELLAGIC-ACID	Leaf	--	--	--	*
Abortifacient 1.2 mg/kg ivn mus * ACE-Inhibitor IC50=5 mM/l * Aldose-Reductase-Inhibitor IC50=0.2 uM * Aldose-Reductase-Inhibitor IC50=0.2 ug/ml (strong activity) * Antiaflatoxin * Antianaphylactic * Antibacterial ID50=20 ug/ml * Antibacterial 1,250 ug/ml * Anticancer (Cervix) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Colon) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Esophagus) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticancer (Mouth) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Anticariogenic ID50=20 ug/ml * Anticataract Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989. Antigingivitic 1,250 ug/ml * AntiGTF ID50=20 ug/ml * AntiHIV IC90=200 ug/ml Tan, G.T., Pezzuto, J.M., Kinghorn,* A.D., Hughes, S.H. Evaluation Of Natural Products As Inhibitors Of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. Journal of Natural Products, 54(1): 143-154, 1991. Antihyperthyroid * Antiinflammatory * Antimalarial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antimutagenic * Antioxidant 2/3 quercetin * Antioxidant >50 x tocopherol Osawa, T. Phenolic Antioxidants in Dietary Plants as Antimutagens.Phenolic Compounds in Food and Their Effects on Health, Ch.11 p.142. Antioxidant IC98=30 ppm * Antiperiodontic 1,250 ug/ml * Antiperoxidant IC50=29 uM Planta Medica, 57: A54, 1991. Antiplaque 1,250 ug/ml * Antiplasmodial IC50=0.5 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp. Antiseptic 1,250 ug/ml * Antistreptococcic ID50=20 ug/ml * Antithyroid Jim Duke's personal files. Antitumor * Antiviral Economic & Medicinal Plant Research, 5: 224. Antiyeast IC50=10.5 uM * Apoptotic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY. Astringent Martindale's 29th Cancer-Preventive 3 ppm * Candida-SAP-Inhibitor IC50=8.4 uM * Cytotoxic 4.6 ug/ml Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 359. Deiodinase-Inhibitor Jim Duke's personal files. Detoxicant * Glucosyl-Transferase-Inhibitor ID50=20 ug/ml * Hemostatic Merck 11th Edition Hepatoprotective IC55=30 ug/ml Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990. HIV-RT-Inhibitor Economic & Medicinal Plant Research, 5: 224. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Pesticide * Quinone-Reductase-Inducer 0.4 g/kg rat Ahn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828. Sunscreen 0.50% Jim Duke's personal files. Topoisomerase-I-Antagonist Journal of Medicinal Food 2: 167.1999. Xanthine-Oxidase-Inhibitor IC50=3.1 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	FAT	Leaf	--	81000.0	0.49	*
0	FAT	Seed	16000.0	36520.0	-1.21	*
15	FIBER	Seed	13200.0	30800.0	-0.82	*
Angiotensin-Receptor-Blocker * Antidiabetic * Antihypertensive * Antiobesity * Antitumor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiulcer Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Beta-Blocker * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective * Diuretic * Hypocholesterolemic * Hypotensive 10 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Hypouricemic * Laxative * Vasodilator *
15	FIBER	Leaf	--	185000.0	0.29	*
Angiotensin-Receptor-Blocker * Antidiabetic * Antihypertensive * Antiobesity * Antitumor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiulcer Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Beta-Blocker * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective * Diuretic * Hypocholesterolemic * Hypotensive 10 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Hypouricemic * Laxative * Vasodilator *

List of all activity chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Castanea sativa (Fagaceae)

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