Apocynum cannabinum | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Bitterroot, Spreading Dogbane

How used

Medicinal

Data Views

Activities: 104

Chemicals w/Activities: 8

All Chemicals: 18

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Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
10	ALPHA-AMYRIN	Root	--	--	--	*
Analgesic * Antiedemic IC43=40 mg/kg ipr rat * Antiinflammatory IC71=1,000 ppm orl * Antinociceptive * Antitumor * Antiulcer * Cytotoxic 50-400 * Gastroprotective * Hepatoprotective * Insectifuge *
0	ANDROSTEROL	Root	--	--	--	*
3	APOCANNOSIDE	Root	--	--	--	*
Anticarcinomic ED50=37 ppb Biosyn. Prod. Cancer Chemotherapy (Petit et al) Antitumor * Cardiac CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
0	CANNOGENIN	Root	--	--	--	*
6	CYMARIN	Root	--	--	--	*
Anticarcinomic ED50=3.9 ppb * Cardiotonic Merck 11th Edition Myocardiotonic * Myotonic * Pesticide * Vasodilator *
1	CYMAROL	Plant	--	--	--	*
Cardiac Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
0	CYNOCANNOSIDE	Root	--	--	--	*
0	FAT	Seed	226000.0	238000.0	-0.14	*
7	HARMALOL	Root	--	--	--	*
Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Antimitotic 10 ug/ml * Aphrodisiac 5 mg/mus CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses CNS-Stimulant * Cytotoxic * Desmutagenic * Pesticide *
0	HOMOANDROSTEROL	Root	--	--	--	*
0	K-STROPHANTHIN	Root	--	--	--	*
21	LUPEOL	Root	--	--	--	*
Antiangiogenic 30-50 ug/ml * AntiEBV * Antiedemic * Antiflu * Antihyperglycemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiinflammatory 1/3 indomethacin * Antilithic 25 mg/kg/day * Antimalarial IC50=46.8 ug/ml Khalid, S.A., Farouk, A., Geary*, T.G., and Jensen, J.B. 1985. Potential Antimalarial Candidates From African Plants: An In Vitro Approach Using Plasmodium falciparum. Journal of Ethnopharmacology, 15: 201-209, 1986. Antioxalate 25 mg/kg/day * Antioxidant 25 mg/kg/day * Antiperoxidant 25 mg/kg/day * Antiprostaglandin * Antirheumatic * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiurethrotic * Antiviral * Cytotoxic 50-500 ppm * FPTase-Inhibitor IC50=65 ug/ml * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * TOPO-2-Inhibitor IC50=10.4 uM *
64	OLEANOLIC-ACID	Root	--	--	--	*
Abortifacient * Antiallergic * Antiarrhythmic 40 mg/kg * Antiatherosclerotic * Antibacterial MIC=625-1,250 ug/ml * Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticariogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticomplement IC40-50 0.01 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Anticomplement IC80-90 0.05 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antiedemic IC36=40 mg/kg ipr rat * Antifertility * Antigingivitic MIC=625-1,250 ug/ml * Antihepatotoxic * AntiHIV IC50=21.8 ug/ml * AntiHIV EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antihyperlipidemic * Antiinflammatory 40 mg/kg ipr Aquino, R., De Feo, V., De Simone, F., Pizza, C., and Cirino, G. Plant Metabolites. New Compounds And Anti-Inflammatory Activity Of Uncaria tomentosa. Journal of Natural Products, 54(2): 453-459, 1991. Antiischemic 40 mg/kg Antileukemic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antileukotriene IC50=17 uM * Antimalarial IC50=70-89 ug/ml * Antinephritic IC50=19-24 uM * Antioxidant IC46=10 uM * Antioxidant Balanehru, S. and Nagarajan, B. 1992. Intervention of Adriamycin Induced Free Radical Damage. Biochemistry International 28(4): 735-744, 1992. Antiperiodontic MIC=625-1,250 ug/ml * Antiperoxidant IC30=200 ug/ml * AntiPGE2 IC50=24 uM * Antiplaque MIC=625-1,250 ug/ml * Antiplasmodial IC50=70-89 ug/ml * Antisarcomic * Antiseptic MIC=625-1,250 ug/ml * AntiTGF-beta IC50=19-24 uM * Antitumor * Antitumor (Breast) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Kidney) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Lung) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Pancreas) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antiulcer >carbenoxolone * Antiviral EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antiviral IC50=21.8 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Aromatase-Inhibitor * Beta-Blocker * Beta-Glucuronidase-Inhibitor ~100 mg/kg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective 40 mg/kg * Cardiotonic * COX-2-Inhibitor Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. COX-2-Inhibitor IC50=295 uM/ * Cyclooxygenase-Inhibitor * Diuretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Elastase-Inhibitor IC50=~15 uM * Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 211. Hypolipemic * Hypotensive * Immunomodulator * Leucocytogenic * NF-kB-Inhibitor * Phagocytotic * Piscicide ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. Prostaglandin-Synthesis-Inhibitor igs mus * Sedative * Uterotonic * Vasopressor *
0	P-OXYACETOPHENONE	Root	--	--	--	*
0	PROTEIN	Seed	287000.0	331000.0	0.86	*
0	RESIN	Plant	--	--	--	*
0	STROPHANTHIN-CYMAROSIDE	Plant	--	--	--	*
35	TANNIN	Plant	--	--	--	*
Anthelmintic * Antibacterial * Anticancer * Anticariogenic * Antidiarrheic * Antidysenteric * Antihepatotoxic * AntiHIV * Antihypertensive * Antilipolytic * Antimutagenic * Antinephritic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antiophidic Economic & Medicinal Plant Research, 5: 363. Antioxidant 1/3 quercetin * Antioxidant IC50=1.44 ug/ml * Antiradicular 500 mg/kg/day orl mus Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antiradicular 1/3 quercetin * Antirenitic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antitumor * Antitumor-Promoter * Antiulcer * Antiviral * Cancer-Preventive HerbalGram No. 22 - Spring 1990, page 14. Carcinogenic * Chelator * Cyclooxygenase-Inhibitor * Glucosyl-Transferase-Inhibitor * Hepatoprotective * Immunosuppressant * Lipoxygenase-Inhibitor * MAO-Inhibitor * Ornithine-Decarboxylase-Inhibitor * Pesticide * Psychotropic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Xanthine-Oxidase-Inhibitor *

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Apocynum cannabinum (Apocynaceae)

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