Chemical THEOBROMINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

THEOBROMINE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=200 (orl cat)
LD50=789 mg/kg (ipr mus)	Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
LD50=1,356 mg/kg (orl mus)	Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
LD50=950 mg/kg (orl rat)	Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Sort descending	Dosage	Reference
Anorexic	not available	Martindale's 28th
Antiasthmatic	10 mg/kg/orl/man	Martindale's 29th
Anticellulitic	not available	Duke, 1992 *
Arteriodilator	not available	Duke, 1992 *
Bronchodilator	not available	Merck 11th Edition
cAMP-Inhibitor	IC50=0.06 mg/ml	Schussler, M., Fricke, U., Nikolov, N., and Holzl, J. 1991. Comparison of the Flavonoids Occurring in Crataegus species and Inhibition of 3',5'-Cyclic Adenosine Monophosphate Phosphodiesterase. Plant Medica 57: Suppl Issue 2. p.A-133.
cAMP-Phosphodiesterase-Inhibitor	not available	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Cardiotonic	not available	Merck 11th Edition
cGMP-Phosphodiesterase-Inhibitor	not available	Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
CNS-Stimulant	not available	Duke, 1992 *
Diuretic	300-600 mg/man/day	Martindale's 28th
Emetic	not available	Martindale's 28th
Fetotoxic	100 mg/kg	Duke, 1992 *
Herbicide	IC41=100 ppm	Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Myocardiotonic	not available	Duke, 1992 *
Myorelaxant	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Myostimulant	not available	Martindale's 29th
Pesticide	not available	Duke, 1992 *
Stimulant	not available	Duke, 1992 *
Teratogenic	100 mg/kg	Duke, 1992 *

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