Chemical URSOLIC-ACID | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

URSOLICACID

Ubiquitous

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Cardiotonic	not available	Duke, 1992 *
Choleretic	5-20 mg/kg orl	Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992.
CNS-Depressant	not available	Duke, 1992 *
COX-2-Inhibitor	IC50=130 uM/	Duke, 1992 *
Cyclooxygenase-Inhibitor	not available	Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215.
Cytotoxic	7.2 uM	Duke, 1992 *
Cytotoxic	50 ppm	Duke, 1992 *
Cytotoxic	ED50=3.75 ug/ml	Duke, 1992 *
Diuretic	not available	Duke, 1992 *
Elastase-Inhibitor	IC50=~15 uM	Duke, 1992 *
Hepatoprotective	10 mg/kg	Duke, 1992 *
Hepatoprotective	1-100 ug/ml	Duke, 1992 *
Hypoglycemic	not available	Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.
Hypotensive	not available	Duke, 1992 *
Immunomodulator	not available	Duke, 1992 *
Leucocytogenic	not available	Duke, 1992 *
Lipoxygenase-Inhibitor	IC50=0.18 mM	Duke, 1992 *
MMP-9-Inhibitor	IC80=10 uM	Duke, 1992 *
Ornithine-Decarboxylase-Inhibitor	not available	Duke, 1992 *
Pesticide	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Agrimonia eupatoria	Plant	not available	6000.0	-0.5	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Arbutus unedo	Leaf	not available	not available	not available	Duke, 1992 *
Arctostaphylos uva-ursi	Leaf	4000.0	7500.0	-0.2	Duke, 1992 *
Arctostaphylos uva-ursi	Plant	not available	not available	not available	Duke, 1992 *
Arctostaphylos uva-ursi	Shoot	not available	not available	not available	Duke, 1992 *
Artocarpus heterophyllus	Root	not available	not available	not available	Chemical Constituents of Oriental Herbs (3 diff. books)
Berberis vulgaris	Fruit	not available	not available	not available	Jim Duke's personal files.
Catalpa bignonioides	Leaf	not available	not available	not available	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Catharanthus roseus	Leaf	not available	not available	not available	CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
Chimaphila umbellata	Shoot	not available	not available	not available	Duke, 1992 *
Chimaphila umbellata	Plant	not available	not available	not available	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Chrysanthemum x morifolium	Flower	not available	not available	not available	Wealth of India.
Cnicus benedictus	Plant	not available	not available	not available	Jim Duke's personal files.
Cornus florida	Plant	not available	not available	not available	Duke, 1992 *
Cornus mas	Flower	not available	not available	not available	Grigorescu, E., Ionescu, A. P. 1976. Isolation of Ursolic Acid from Cornus mas (Cornaceae). Phytochemistry, 15: 1097.
Cornus mas	Shoot	not available	not available	not available	Zorina, A. D., Matyukhina, L. G., Ryabinin, A. A. 1966. Triterpenes in Some Plant Species. Chem Nat Comp, 2(4): 291.
Cornus officinalis	Fruit	not available	not available	not available	Duke, 1992 *
Cornus officinalis	Seed	not available	not available	not available	Duke, 1992 *
Crataegus cuneata	Fruit	not available	not available	not available	Duke, 1992 *
Crataegus laevigata	Plant	not available	not available	not available	Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.